Clinical Trials
Category Added in a WPeMatico Campaign
-
Integrating NCCN and LATITUDE in metastatic castration-sensitive prostate cancer: a TITAN analysis
To evaluate whether an integrated classification combining the CHAARTED and LATITUDE criteria improves prognostic stratification and to explore treatment effects across risk groups, including further stratification by metastasis timing, in metastatic castration-sensitive prostate cancer (mCSPC). This post hoc analysis included 1,052 patients from the TITAN trial (NCT02489318) randomized to receive apalutamide plus androgen deprivation therapy…
-
Effects of Early Enteral Nutrition After Total Gastrectomy for Gastric Cancer
CONCLUSION: This study demonstrates comparable and in some key indicators higher clinical and economic efficiency of domestic enteral nutrition products in perioperative period for cancer patients with nutritional disorders. This may be explained by minor biologically active substances in domestic nutrition improving not only protein absorption in the body, but also metabolic and detoxification processes.
-
Can online peer influencers accelerate HIV testing among young adult males living in Nairobi, Kenya? A study protocol
CONCLUSION: Findings will provide rigorous evidence to inform HIV testing policies and scalable digital behavior change interventions targeting young men in Nairobi and similar urban settings.
-
Management of post-operative pain by metoclopramide in patients undergoing cesarean section: A double-blinded randomized clinical trial
CONCLUSION: Metoclopramide significantly reduced early post-operative pain and opioid requirements, with reductions exceeding minimal clinically important difference thresholds. While statistically robust, these benefits should be weighed against its transient antiemetic effects and the need for larger trials to confirm functional recovery benefits.
-
Comparison of oral tizanidine and baclofen for post-operative pain management after femoral fracture surgery
CONCLUSIONS: Preoperative administration of 4 mg tizanidine and 25 mg baclofen showed comparable efficacy in post-operative pain management. As this study lacked a placebo control, it cannot confirm the absolute analgesic efficacy of either drug over no treatment. Although tizanidine demonstrated a trend toward lower pain scores at certain intervals, these differences were not statistically…
-
A randomised, double-blind, placebo-controlled crossover trial on cannabinoid-based medication for behavioural disorders in old patients with severe dementia: the study results
CONCLUSIONS: In this real-life crossover study, THC/CBD oil did not show superiority over placebo in reducing agitation in severe dementia. However, it was safe and associated with a significant reduction in the use of as-needed psychotropic medications prescribed for behavioural and psychological symptoms of dementia. CBM may represent a possible adjunctive option in selected patients,…
-
Beware of What You Expect? A Partial Replication Study on the Behavioral and Psychophysiological Effects of Negative Expectations on Mechanical Hypersensitivity
Mechanical hypersensitivity of uninjured skin surrounding a cutaneous injury is a sign of plasticity of the nociceptive system and can be induced in healthy individuals using high-frequency electrical stimulation (HFS). However, despite a broad body of evidence for acute painful stimuli, mixed results have been reported concerning the role of negative expectations in the development…
-
Effectiveness of Lotrafilcon B and Balafilcon A bandage contact lenses on epithelial healing and visual symptoms after transepithelial photorefractive keratectomy in the hyperopic patients
CONCLUSIONS: Lotrafilcon B bandage contact lenses are more effective than Balafilcon A lenses in reducing ocular pain during the postoperative period of T-PRK.
-
Prospective Comparison of Ultra-Low-Dose Versus Standard-Dose Computed Tomography for Esophageal Foreign Body Detection
The objective of this study was to verify the non-inferiority of ultra-low-dose computed tomography (ULD-CT) versus standard-dose CT (SD-CT) for esophageal foreign body (EFB) detection and to quantify dose-quality trade-offs. This prospective, randomized, blinded-reader study enrolled 180 patients (120 adults, 60 children) presenting with suspected EFB ingestion. Patients were randomized to ULD-CT (100 kV/50 mA,…
-
Gross motor function, functional level, physical performance, and muscle strength in preschool children newly diagnosed with cancer: Data from the RePlay trial
CONCLUSION: These results show that preschoolers newly diagnosed with cancer have gross motor function, functional level, and muscle strength impairments, underlining the importance of targeted physical rehabilitation.