Clinical Trials
Category Added in a WPeMatico Campaign
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Enhancing Self-Awareness in Older Adults With Mild Cognitive Impairment: A Preliminary Randomized Controlled Trial of the Feuerstein Instrumental Enrichment Program
CONCLUSIONS: The FIE program produced significant and durable improvements in self-awareness of memory abilities in older adults with MCI. Findings support the clinical utility of mediated learning approaches for addressing metacognitive deficits in this at-risk population, with implications for rehabilitation engagement and dementia prevention efforts.
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Early-life serum protein profiles associated with bronchopulmonary dysplasia in extremely preterm infants
CONCLUSION: Differences in early serum protein trajectories are evident in infants who develop BPD. Our findings suggest associations consistent with proposed pathophysiological mechanisms. Clinical factors likely interact with immune-related proteins in the development of BPD. Mitigating inflammation by stabilising potential protective factors could be important for BPD prevention.
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Efficacy and Safety of Tofacitinib Versus Placebo in Patients With Early-Grade Knee Osteoarthritis: A Randomized, Double-Blind, Placebo-Controlled Trial
CONCLUSION: Tofacitinib was not superior to placebo in early-grade knee osteoarthritis, and the large within-group improvement rebounded toward baseline by 6 months, consistent with a predominantly non-specific (contextual) response. Because participants were selected radiographically without inflammatory phenotyping, these findings do not support tofacitinib in unselected early-grade disease but cannot exclude benefit in an inflammatory phenotype;…
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High potency and water dispersible Boswellia extract reduces pain and inflammation in subjects with osteoarthritis of the knee: A randomized, double-blind, placebo-controlled trial
CONCLUSION: Based on the current study findings, it can be concluded that OLNP-27 is an effective and safe natural option for the management of symptoms associated with osteoarthritis of the knee.
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Bone lid technique versus standard curettage for maxillofacial cysts: a prospective 3D CBCT study of bone regeneration and tooth stability
CONCLUSION: The Bone Lid Technique was associated with more favorable early bone regeneration and enhanced tooth stability compared with standard curettage. However, the robustness of the surface-area finding should be interpreted cautiously because baseline lesion morphology differed between groups and the corresponding sensitivity estimate was less stable. It may be particularly beneficial for moderate-sized cystic…
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Cost-Effectiveness of Community-Based Rehabilitation for People With Schizophrenia: A Secondary Analysis of a Cluster Randomized Trial
CONCLUSIONS AND RELEVANCE: In this secondary analysis of a cluster randomized trial, group-based CBR for schizophrenia in China was associated with improved outcomes and a high probability of cost savings, supporting its scaled implementation in resource-constrained settings.
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Subcutaneous MG1113 in severe hemophilia A and B: phase 1b study for safety, pharmacokinetics, and pharmacodynamics
CONCLUSION: MG1113, administered subcutaneously as a prophylaxis in patients with severe hemophilia A or B without inhibitors for 8 weeks, demonstrated an acceptable safety profile with a PK profile suitable for once-a-week dosing. The pharmacodynamics marker changes were consistent with TFPI inhibition, which was associated with reductions in bleeding events.
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Superior-head automated external defibrillator placement during single-rescuer cardiopulmonary resuscitation: a randomized crossover simulation study and retrospective multicenter cohort
CONCLUSION: Superior-head AED placement improved the efficiency, compression continuity, and workload of simulated single-rescuer CPR. The retrospective clinical findings were directionally consistent but statistically inconclusive and should be regarded as hypothesis-generating rather than confirmatory. Prospective validation is required before clinical implementation.
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Detection and treatment of peritoneal metastases in colon cancer: COLOPEC trial compared to routine practice
CONCLUSION: Despite increased detection and more frequent treatment of peritoneal metastases in the COLOPEC trial, 5-year overall and disease-free survival were comparable to routine practice.
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18F-FDG PET/CT metabolic parameter to predict pathological complete response and survival after neoadjuvant immunotherapy plus chemoradiotherapy in resectable esophageal squamous cell carcinoma
CONCLUSIONS: None of the single metabolic parameters of the primary tumor were significant predictors of pCR-tu. LnSUVmax2 has diagnostic value for lymph nodes metastasis. The patients with SUVmax2 ≥ 12.4 and LnSUVmax2 ≥ 7.9 had poorer OS and DFS, but they are not independent prognostic factors, which needs to be confirmed by larger scale clinical…