Clinical Trials
Category Added in a WPeMatico Campaign
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Investigation of the effectiveness of cooling spray on mammography comfort
Breast cancer is one of the most common cancer types in recent years. Early diagnosis of breast cancer increases the success of treatment. Breast cancer screening is thus highly critical. Mammography is a screening tool that is still globally valid. I would propose that Mammography can potentially be painful. In our study, we aimed to…
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Use of a Generative Pretrained Transformer to Answer Questions and Facilitate a Large Randomized Controlled Trial
CONCLUSIONS: This novel use of a customized GPT suggests it could be valuable in support of clinical sites within a large trial. Further research should confirm equivalent accuracy and safety through a direct comparison to human support.
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Randomized trial of the effect of esomeprazole on functional dyspepsia during Ramadan fasting
Dyspeptic symptoms are frequently encountered during Ramadan and may be exacerbated by changes in eating habits. We assessed the efficacy of esomeprazole in patients with functional dyspepsia (FD) who fasted during Ramadan. In this randomized, double-blind controlled study, 245 patients diagnosed with FD who completed Ramadan fasting were randomly assigned (1:1 ratio) to receive either…
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Linked color imaging improves polyp miss rates in total colonoscopy in a multicenter randomized back to back trial
Linked color imaging (LCI) was developed to detect gastrointestinal neoplasms. The current study aimed to determine whether the use of LCI, compared with white-light imaging (WLI), can improve the miss rates of colorectal polyp. A multicenter, randomized back-to-back study was conducted in 16 Japanese endoscopy units. Patients were randomized according to examination: tandem colonoscopy with…
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Effects on chemotherapy-induced peripheral neuropathy by moderate strength training in combination with whole-body vibration in breast cancer patients
CONCLUSION: Both strength training alone and combined with WBV are feasible and safe during chemotherapy. Although WBV did not provide additional benefits over strength training alone, both interventions showed potential protective effects against CIPN symptoms.
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A national randomized controlled trial of the impact of public Montessori preschool at the end of kindergarten
Although seminal studies from the early 1960s suggested quality preschool can have lasting positive effects, agreement is lacking on the efficacy of different preschool models. The Montessori model is longstanding but lacks rigorous impact studies; prior random lottery studies included just one or two schools, among other compromises. Here, we report on end-of-kindergarten (age 5…
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Comparative efficacy of high intensity laser therapy (Class IV) and ibuprofen gel phonophoresis in the treatment of knee osteoarthritis among people living in hilly terrain: A randomized controlled study
Knee osteoarthritis (KOA) commonly causes pain and functional limitations, especially in hilly areas where mobility demands increase stress on the knee joint. High-Intensity Laser Therapy (HILT) and Ibuprofen Gel Phonophoresis (IGP) are both effective treatments, though comparative data is limited. Hence, we aimed to determine the effect of high-intensity laser therapy (HILT) (class-IV) and ibuprofen…
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Effect of Back Optical Zone Diameter of Orthokeratology Lens on Visual Quality in Myopic Children
CONCLUSION: In myopic children, wearing ortho-k lenses with different BOZD results in improved subjective satisfaction, with no difference in subjective visual quality. However, objective visual quality declined in both groups, with a greater impact observed in the 5 mm group.
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Efficacy of Transfer Energy Capacitive and Resistive Therapy Combined With β-Hydroxy-β-Methylbutyrate Nutritional Supplementation in Older Adults With Sarcopenic Obesity
CONCLUSION: TECAR therapy combined with HMB supplementation significantly enhances physical function, activities of daily living, and body composition in elderly patients with sarcopenic obesity, demonstrating a synergistic effect.
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Comparison of supervised versus home-based exercise programs following platelet-rich plasma injections in knee osteoarthritis: clinical outcomes from quasi-experimental study
CONCLUSION: Both supervised and unsupervised exercise programs improved outcomes in knee OA patients following PRP injections; the supervised program showed greater pain relief, flexion ROM, and functional status. However, no significant difference was observed in knee extension ROM between the two groups.