Clinical Trials
Category Added in a WPeMatico Campaign
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Clinical validation of continuous glucose monitoring in glycemic management of critically ill sepsis patients: A prospective randomized clinical study
ObjectiveThis study assessed the accuracy, clinical effectiveness, and utility of continuous glucose monitoring compared with conventional methods in critically ill patients with sepsis.MethodsFrom July 2023 to July 2025, 60 patients with sepsis (mean age, 75.6 ± 27.107 years; mean body mass index, 22.4 ± 2.960 kg/m²) were randomized to the continuous glucose monitoring (FreeStyle Libre…
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Effect of a digital intervention on mental health symptoms in adults with chronic conditions: A three-arm randomized controlled trial
CONCLUSIONS: A multicomponent digital intervention with human support significantly reduced anxiety and depression symptoms compared with usual care in adults with chronic medical conditions. Comparable effects between self-directed and human-supported delivery in exploratory analyses highlight potential for scalable, low-resource implementation. Longer-term follow-up and cost-effectiveness analyses are warranted. Trial registration: ClinicalTrials.gov: NCT05786482.
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Effect of Mendelsohn maneuver combined with heat-sensitive moxibustion at Lianquan (CV23) on swallowing function and complications in patients with post-stroke dysphagia
CONCLUSIONS: The Mendelsohn maneuver combined with heat-sensitive moxibustion at CV23 can effectively activate the pharyngeal constrictor muscles, improve sEMG signals, promote the recovery of swallowing function in patients with post-stroke dysphagia, and exert positive effects in reducing related complications, improving nutritional status and quality of life.
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Emotional support or problem-solving? A randomized controlled trial of function-specific AI Chatbots for digital stress in college students
Digital stress has emerged as a salient risk factor for the mental health of emerging adults, yet targeted interventions remain limited. Generative AI chatbots offer a scalable approach to delivering context-sensitive supportive interactions that users may perceive as emotional or informational support. This randomized controlled trial tested two functionally specialized AI chatbots-emotional-support and problem-solving-in reducing…
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Providing Feedback on Previous Pain Scores Did Not Affect Weekly Pain Variability: A Cohort-Nested Randomised Study
CONCLUSIONS: Providing participants with feedback on their previous pain score did not meaningfully influence within-person pain variability or retention during 60 weeks of weekly monitoring. These findings aid the interpretation of repeated longitudinal pain assessments by showing that the observed variability was robust to this specific study design.
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Improving emergency management of status epilepticus: a randomized high-fidelity simulator-based trial
CONCLUSIONS: Condensed SE guidelines improved adherence to selected emergency interventions compared with both full NCS guidelines and no guideline support. Guideline usability may represent a modifiable target for improving time-critical neurological emergencies.
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Therapist-guided and self-guided internet-based behavioural activation versus treatment as usual for adolescents with depression: randomised controlled trial with economic evaluation
CONCLUSIONS: Therapist-guided I-BA reduced depressive symptoms at lower cost than TAU, but clinical importance and robustness are uncertain. Self-guided I-BA showed no clear superiority but was cost-efficient.
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A Women-Centered Internet-Based Cognitive Behavioral Therapy for Depressive Symptoms (the 3D Program): Protocol for a Randomized Controlled Trial
CONCLUSIONS: This trial aims to address critical gaps in accessible, personalized, and gender-sensitive mental health care. If effective, the 3D Program may serve as a scalable, cost-efficient adjunct to routine care for women with depressive symptoms in public health systems, while biomarker findings may lay the groundwork for future trials examining predictors of response.
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Comparative Evaluation of Virtual Reality versus Standard Nursing Care in Managing Pain and Fear during Lumbar Puncture Procedures: A Randomised Controlled Trial
CONCLUSIONS: The research shows that the use of VR prior to LP significantly reduces level of pain and fear compared to standard care. These results support VR as a non-pharmacological intervention for fear and pain to improve patient experience during invasive procedures. In contrast, the control group experienced no improvement.Trial Registration: The IRCT code for…
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Online psychoeducation and assessment for borderline personality disorder as a first step of care: A pilot study assessing safety, feasibility, and mechanisms of change
CONCLUSION: Online psychoeducational videos and assessment were safe, feasible, and acceptable to participants with newly diagnosed BPD. Psychoeducation with personalized feedback appears to be more effective than either BPD or general psychoeducation alone in improving deficits in self-functioning, which may relate to an increased capacity to be alone with fewer symptoms.