Clinical Trials
Category Added in a WPeMatico Campaign
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Brief Prolonged Exposure Therapy for Posttraumatic Stress After Spinal Cord Injury: A Randomized Controlled Trial
CONCLUSION: Brief PE was feasible, acceptable, and produced greater pain reduction than TAU. PTSD symptoms were also lower, though not significantly, suggesting promise for early psychological intervention after SCI.
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Motivation to Participate in a Nutrition and Physical Activity Intervention During Chemotherapy for Breast Cancer: A Qualitative Study
CONCLUSIONS: Women with breast cancer were motivated to participate in a nutrition and exercise intervention initiated during chemotherapy because of factors relating to optimizing their own health, altruistic desires, perceived lack of harm, and their oncologist’s recommendation. Compared to post-treatment, the opportunity to be proactive and having an oncologist recommendation emerged as unique motivators. Understanding…
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Visual Acuity Screening By by School Teachers in Far West Nepal: A randomized trial of alternate screening models
Background Studies have not examined alternate school visual acuity screening methods in Nepal in terms of accuracy and cost. Objective To validate recent evidence from India of the effectiveness and cost of alternate school visual acuity screening models involving all class teachers (ACTs) versus a few selected teachers (STs). Method This was a prospective cluster…
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Behaviorally Informed Text Messaging to Promote Colon Cancer Screening: A Quality Improvement Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this quality improvement randomized clinical trial, a behaviorally informed text messaging strategy was associated with significantly improved FIT completion compared with usual nurse-led telephone outreach. Automated messaging may offer a scalable, low-cost strategy to promote preventive care and reduce staff burden in underserved populations.
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The Impact of Endoscopic Ultrasound and Multidisciplinary Team Evaluation on the Management of Pancreatic Cystic Lesions
CONCLUSION: While susceptible to cognitive bias, EUS significantly improves MDT assessment of PCL. MDT establishes a high bar for iterative additions of biomarkers to PCL analysis.
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Effect of the online Rethink My Drink alcohol intervention on alcohol use and cognition in older adults in Australia: a randomised controlled trial
BACKGROUND: Alcohol use is increasing among older adults and is associated with cognitive impairment and dementia. The efficacy of scalable approaches to reduce alcohol use and related harms in older adults has not been tested. This study aimed to evaluate the efficacy of an online alcohol intervention in reducing alcohol use and cognitive decline in…
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Efficacy of a simplified photobiomodulation protocol in orthodontic patients: a randomized crossover clinical trial
CONCLUSION: The study shows that photobiomodulation can help control orthodontic pain, being well accepted by participants and not extending clinical time. However, the analgesic effects are still limited, indicating the need to refine the protocol to enhance its effectiveness.
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The impact of muscle energy technique and aromatherapy on pain, disability, and sleep quality in office workers with nonspecific neck pain: randomized controlled study
CONCLUSION: This study provides evidence that both aromatherapy and muscle energy technique are safe and practical treatments, which are efficacious in the reduction of pain, disability, and sleep quality in nonspecific neck pain.
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Topical ROCK inhibition accelerates recovery after Descemetorhexis Without Endothelial Keratoplasty (DWEK) in Fuchs endothelial corneal dystrophy: a prospective comparative clinical trial
CONCLUSIONS: Adjunctive topical ripasudil after DWEK accelerates endothelial recovery, corneal deturgescence, and visual rehabilitation compared with DWEK alone, without compromising safety.
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The journey to diagnosis and care of functional neurological disorder (FND)
CONCLUSION: The findings emphasize the need for personalised and compassionate care for individuals suffering from FND, underpinned by increased service provision within the healthcare system.