Clinical Trials
Category Added in a WPeMatico Campaign
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Effect of community-based intensive smoking cessation intervention on smoking behavior and blood pressure control in hypertensive patients
CONCLUSION: The intensive smoking cessation intervention significantly increased smoking abstinence rates, reduced cigarette consumption, and improved blood pressure control among hypertensive patients in community settings.
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Toward evidence-based prescription of prosthetic ankle-foot devices: A multisite randomized crossover trial identifying performance-based, patient-reported, and biomechanical parameters sensitive to device type
Prescription of prosthetic ankle-foot devices is constrained by imprecise clinical guidelines and inconsistent scientific evidence, hindering optimal device selection for individuals with lower limb loss. This multisite, prospective, randomized crossover study aimed to identify patient-reported, performance-based, and biomechanical parameters sensitive to ankle-foot device type, providing a foundation for more objective and individualized prescription practices. Ninety-one…
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Digital Simulation-Based Ultrasound Training for Physiotherapy Students: Prospective Randomized Controlled Trial
CONCLUSIONS: Simulation-based online ultrasound training provides comparable theoretical and practical outcomes to traditional on-site instruction, supporting its use as a scalable and accessible educational alternative.
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Testing behavioral economics principles in mailed FIT outreach: a randomized trial
CONCLUSION: The FIT test screening rate in the enhanced communication group was not statistically different from the original communication group. Using evidence-based behavioral economics principles in mailed FIT communications did not markedly improve the rate of CRC screening, but mailed FIT remains a key, cost-effective tool for reaching unscreened individuals.
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Decoding patient preferences: key drivers in selecting thyroid cancer surgery- a discrete choice experiment
CONCLUSION: Recurrence risk is the primary driver of surgical preference in PTC patients, followed by cosmetic outcomes. Additionally, postoperative cosmetic concerns varied across different demographic groups. These findings highlight the need for surgeons to consider patient-specific values during preoperative consultations to enhance shared decision-making.
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Traditional Chinese medicine syndrome patterns and associated factors in adults with type 2 diabetes and metabolic syndrome: a data-driven analysis
CONCLUSION: This study demonstrates that complementary data-driven methods, specifically PCA and LCA, can effectively map the heterogeneous landscape of TCM syndromes in patients with comorbid T2DM and MetS. The analysis validates core constructs, including Phlegm and Blood Stasis, and links deficiency syndromes to severe fatigue and poor sleep. Future TCM syndrome research may benefit from…
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Multivitamin supplementation and COVID-19 incidence and symptom severity in the COcoa Supplement and Multivitamin Outcomes Study (COSMOS) randomized trial
CONCLUSIONS: A daily MVM supplement, compared with placebo, does not significantly reduce COVID-19 incidence among older adults but shows a promising signal lowering the odds of symptomatic COVID-19 illness. The Cocoa Supplement and Multivitamin Outcomes Study was registered at clinicaltrials.gov as NCT02422745.
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Rituximab versus Ocrelizumab in Newly Diagnosed Relapsing Multiple Sclerosis
CONCLUSIONS: In participants with newly diagnosed relapsing multiple sclerosis and recent disease activity, rituximab was noninferior to ocrelizumab in suppressing disease activity as detected by MRI from 6 to 24 months, with a similar incidence of serious adverse events. (Funded by the Research Council of Norway and others; OVERLORD-MS ClinicalTrials.gov number, NCT04578639; EudraCT number, 2020-001205-23;…
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Major Depressive Disorder and PTSD Treatment Outcome in Interpersonal Psychotherapy and Prolonged Exposure
Objective: Trauma-focused psychotherapies are first-line treatments for posttraumatic stress disorder (PTSD). For veterans, however, response rates are low, and dropout tends to be high. Some evidence suggests that those with comorbid depression are less likely to complete treatment and improve less in trauma-focused treatments. This study examined treatment noncompletion and PTSD symptom outcomes among veterans…
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Impact of reinforced pancreaticojejunostomy with or without tissue adhesive glue modified cyanoacrylate following pancreaticoduodenectomy: a randomized controlled clinical trial
CONCLUSIONS: In this single-center randomized trial, reinforcement of pancreaticojejunostomy with Glubran^(®)2 was associated with a significantly lower rate of POPF (Grade B/C), shorter time to drain removal, lower overall morbidity, and shorter length of hospital stay, with an acceptable safety profile. These hypothesis-generating findings warrant confirmation in an adequately sized, multicenter trial with operator-independent application…