Clinical Trials
Category Added in a WPeMatico Campaign
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Improvements in Health-Related Quality of Life After Financial Navigation Among Cancer Survivors
CONCLUSIONS: Our findings demonstrate that receipt of FN decreased anxiety and depression and improved global mental health. Findings highlight the crucial role of FN in cancer care.
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Dose-Response Relationship of Single Intravenous Remimazolam on Bispectral Index and Cardiorespiratory Effects
CONCLUSION: A dose-dependent relationship exists between single-dose remimazolam and BIS, with good respiratory and circulatory safety in the 0.2-0.6 mg/kg range and a plateau effect above 0.4 mg/kg. The extremely wide confidence interval for the ED(90) estimated using the BIS ≤ 60 threshold suggests that this endpoint may not be suitable for pharmacodynamic evaluation of…
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Changes in perceived psychosocial working conditions after psychotherapeutic consultation at work — exploratory post-hoc analyses from a randomized controlled trial
CONCLUSIONS: Results may indicate that participation in PT-A is associated with long-term reductions in perceived emotional demands and dissolution, but not with improvement in perceived job resources. Confirmative research is needed given the exploratory study design and because findings did not remain statistically significant after adjustment for multiple testing.
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The effect of cycloplegia on corneal power and diameter measured by an auto-kerato-refractometer in presbyopic patients with type 2 diabetes mellitus: a post-hoc analysis of a randomized clinical trial
CONCLUSIONS: Post-cycloplegia keratometry and WTW measurements were comparable to pre-cycloplegia values in presbyopic patients with type 2 diabetes, suggesting that these measurements can be reliably obtained after cycloplegia.
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Feasibility and acceptability of the Unified Protocol for anxiety and depression in Pakistan: a pilot randomized controlled trial
CONCLUSIONS: The UA-UP demonstrated high feasibility and acceptability as a culturally adapted transdiagnostic CBT intervention in Pakistan. These findings support the conduct of a fully powered randomized controlled trial to evaluate clinical effectiveness and inform scalable implementation in low-resource settings.
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Continuous Remote Patient Monitoring in Heart Failure Patients: The Heart Failure Cascade Study: Phase II and III Outcomes
ABSTRACT: OBJECTIVES: The objective of this study is to evaluate the effect of a continuous remote patient monitoring (CRPM) program on reducing 30-day readmissions in a case-versus-retrospective-propensity-matched-control study of heart failure (HF) patients.
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Supporting the Primary Outcomes of the Mirai Trial for the Adjunctive Digital Therapeutic Rejoyn (CT-152) in the Treatment of Major Depressive Disorder: Meaningful Change Analysis in the Montgomery-Asberg Depression Rating Scale
CONCLUSIONS: Results are consistent with the primary findings of the Mirai trial, supporting the efficacy of Rejoyn as an adjunctive treatment to antidepressive medication monotherapy for adults with major depressive disorder. The MWPC analyses offered a measure of meaningful change on the MADRS, providing a framework of clinical meaningfulness for the Mirai trial findings.
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An Open-Label, Dose-Escalation Trial of Psilocybin-Assisted Therapy for Bipolar II Depression
Objective: Individuals with bipolar II disorder (BD-II) and depression face limited treatment options and are often excluded from psilocybin therapy trials due to concerns about precipitating mania or psychosis. The objective of this study was to evaluate the safety, tolerability, and preliminary efficacy of psilocybin therapy in individuals with BD-II and depression.
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Effects of exergame combined with elastic band resistance training on exercise self-efficacy and physical activity levels in older adults with cognitive frailty: A mixed-methods study
CONCLUSIONS: Exergame combined with elastic band resistance training effectively improves exercise self-efficacy and physical activity levels among community-dwelling older adults with cognitive frailty. The beneficial effects of this intervention may be attributed to its positive impacts on enhancing exercise enjoyment, promoting health perceptions, and improving social interaction. This program provides a practical exercise intervention model…
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Impact of Simulation-Based Training on Audiology Students’ Professional Competences: A Pilot Randomized Study
CONCLUSIONS: Simulation-based training was more effective than case-scenario observation, even when observation was paired with structured debriefing, highlighting the added value of hands-on, experiential participation.