Clinical Trials
Category Added in a WPeMatico Campaign
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Effects of an additional multimodal intervention (MultiMove) during inpatient rehabilitation on clinical and functional outcomes in patients with chronic low back pain- a pilot trial
CONCLUSION: Data indicate that the multimodal intervention MultiMove improved clinical and functional outcomes in CLBP patients during inpatient rehabilitation. Therefore, conducting a randomized controlled trial with a large sample size is recommended to verify and extent these results.
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Phantom-based training of ultrasound-guided breast biopsy in medical education: a randomized controlled trial comparing handheld and high-end ultrasound
CONCLUSIONS: Percutaneous biopsy performed by novices using HUDs is feasible, performance times, success rates, operability and the individually perceived workload were on par with HEUS-guidance. HUDs can be used as cost-effective tools for percutaneous biopsy training purposes in medical education.
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Comparative efficacy and safety of nalbuphine and hydromorphone in painless colonoscopy techniques: a randomized controlled trial
CONCLUSIONS: While nalbuphine and hydromorphone effectively maintain intraoperative vital signs, nalbuphine offers superior postoperative comfort. This makes nalbuphine a preferable analgesic choice in outpatient colonoscopy settings. Further research is warranted to determine the optimal dosages for both drugs and to explore their mechanisms of action in procedural pain management.
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Impact of fixed-point rotational reduction of the spine on pain scores and lower limb motor function in patients with lumbar facet joint disorder
CONCLUSION: The application of fixed-point rotational reduction of the spine has shown remarkable efficacy in alleviating pain among patients diagnosed with lumbar facet joint disorder. It also facilitates restoration of lumbar mobility, functional improvement, balance enhancement, and patient rehabilitation. These findings highlight its clinical relevance and potential for therapeutic intervention.
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Outcomes After CABG Compared With FFR-Guided PCI in Patients Presenting With Acute Coronary Syndrome
CONCLUSIONS: The risk of death, MI, or stroke at 3 years was similar after CABG compared with FFR-guided PCI in patients presenting with NSTE-ACS, but reduced by CABG in patients presenting with CCS. (Fractional flow reserve versus Angiography for Multivessel Evaluation [FAME 3]; NCT02100722).
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Early psychosis service user views on digital remote monitoring: a qualitative study
CONCLUSIONS: This study shed light on early psychosis service users’ experiences with using the ClinTouch digital remote monitoring app. ClinTouch was viewed as acceptable for monitoring symptoms, safe and easy to use, showed potential of integration with clinical care, and facilitated increased awareness and understanding of symptoms. Improvements including personalised question items and interactive features…
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PRERISK Study: A Randomized Controlled Trial Evaluating a sFlt-1/PlGF-Based Calculator for Preeclampsia Hospitalization
CONCLUSIONS: Routine screening with the PRERISK score and a 5% cutoff in patients with suspected or confirmed preeclampsia does not decrease hospitalization and is therefore not recommended.
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Experience with the use of undenatured type II collagen in patients with stage III knee osteoarthritis: a multicenter, prospective, double-blind, placebo-controlled, randomized trial
CONCLUSION: Artneo showed high efficacy and safety in the general population of patients, including those with stage III knee OA.
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Predicting Postoperative Circulatory Complications in Older Patients: A Machine Learning Approach
CONCLUSION: We have developed and validated an algorithm for predicting PCCs in elderly patients by identifying key risk factors.
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Non-Invasive Auricular Acupoint Stimulation Improves Slow-Transit Constipation: Evidence From a Randomized Controlled Trial
BACKGROUND Slow-transit constipation lacks optimal therapies due to the adverse effects and limited efficacy of current treatments. Auricular acupoint stimulation offers a potential adjunctive approach through neuromodulation, yet its clinical efficacy and mechanistic role in slow-transit constipation remain unestablished. MATERIAL AND METHODS Sixty patients diagnosed with slow-transit constipation, ranging in age from 40 to 75…