Clinical Trials
Category Added in a WPeMatico Campaign
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Feasibility, Effectiveness, and Acceptability of a Telemedicine Neurological Consultation for Drug-Induced Movement Disorders; A Randomized Pilot Study
BACKGROUND: Individuals exposed to neuroleptics are at risk of developing a drug-induced movement disorder (DIMD). Early identification and appropriate management are necessary to minimize the risk of DIMDs worsening and becoming irreversible. Movement disorder neurologists can assist other clinicians in assessing the cause of the DIMD and make care recommendations. The aim of this study…
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Evaluation of parenting interventions for those with additional health and social care needs during pregnancy: THRIVE a multi-arm RCT with embedded economic and process components
CONCLUSIONS: With the population THRIVE involved, at a stage of pregnancy when a lot of support is offered (with many parenting interventions being offered without rigorous evaluation), we do not have evidence to recommend the rollout of Enhanced Triple P for Baby or Mellow Bumps.
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Microbiological Analysis of Lower Airway Samples: Does It Influence the Outcome in Patients With Community-Acquired Pneumonia?
This prospective randomized trial examined the impact of extensive lower respiratory tract sampling and microbial analysis on treatment decisions and patient outcomes in community-acquired pneumonia (CAP). One hundred and eighteen patients were randomized to rigorous sampling (intervention group, n = 64) or standard care (control group, n = 54). The primary outcome was antibiotic therapy…
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Clinical and cost-effectiveness of lithium versus quetiapine augmentation for treatment-resistant depression in adults: LQD a pragmatic randomised controlled trial
CONCLUSIONS: As well as being more cost-effective, quetiapine may be a more clinically effective augmentation option for treatment-resistant depression.
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Upadacitinib as monotherapy in patients with rheumatoid arthritis and prior inadequate response to methotrexate: results at 260 weeks from the SELECT-MONOTHERAPY randomised study
CONCLUSION: No new safety risks were identified with long-term UPA treatment. UPA monotherapy was efficacious in treating rheumatoid arthritis through week 260.
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The Reliability of a Novel Structured Testing Device for Single-breath Lung Carbon Monoxide Uptake: A Randomized Comparison Crossover Study
CONCLUSION: The MeHow MeAir 9000 spirometer provides high accuracy measurements of lung diffusing capacity and reliable assessment of the severity of diffusing capacity impairment, making it suitable for clinical use.
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Reliability and usability of a portable spirometer compared to a laboratory spirometer
CONCLUSIONS: The portable spirometer exhibited a strong correlation and agreement with a high-quality laboratory spirometer, as well as concordance in spirometric abnormality diagnosis and severity classification. Non-specialist can obtain acceptable results using this portable spirometer.
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Long-term efficacy and safety of upadacitinib in patients with moderately to severely active ulcerative colitis: an interim analysis of the phase 3 U-ACTIVATE long-term extension study
BACKGROUND: The U-ACTIVATE long-term extension study aims to evaluate the long-term efficacy and safety of upadacitinib in patients with moderately to severely active ulcerative colitis. Here, we report interim results after 3 years of total treatment.
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Study protocol of an early randomized intervention trial assessing the metabolic effects of two levels of exercise intensity in children undergoing cancer treatment: the APACIS study
BACKGROUND: Insulin sensitivity is a key factor of the development of metabolic diseases, highly prevalent in adult survivors of childhood cancers. The aim of the Adapted Physical Activity for children treated for Cancer and Insulin-Sensitivity (APACIS) study is to investigate the effects of two exercise programs started as early as diagnosis on metabolic profile and…
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Evaluation of the Impact of Mobile Health App Vitadio in Patients With Type 2 Diabetes: Randomized Controlled Trial
CONCLUSIONS: This trial provides evidence for the superior efficacy of Vitadio in lowering the HbA(1c) levels in T2DM patients compared to standard care. In addition, Vitadio contributed to improvements in cardiometabolic health, reduced diabetes-related distress, and enhanced self-management, highlighting its potential as an accessible digital tool for comprehensive diabetes management.