Clinical Trials
Category Added in a WPeMatico Campaign
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High-intensity interval training improves insulin sensitivity in individuals with prediabetes
CONCLUSIONS: Twelve weeks of low-volume HIIT training can improve glucose control and induces adaptations in skeletal muscle important for metabolic health in individuals with prediabetes.
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Four cycles of docetaxel plus cisplatin as neoadjuvant chemotherapy followed by concurrent chemoradiotherapy in stage N2-3 nasopharyngeal carcinoma: phase 3 multicentre randomised controlled trial
CONCLUSIONS: Four cycles of docetaxel plus cisplatin neoadjuvant chemotherapy with concurrent chemoradiotherapy can effectively reduce distant metastasis and improve survival for patients with stage N2-3 nasopharyngeal carcinoma with manageable toxicities.
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Mood reactivity to daily social conflict in hostile adults: An experimental intervention
CONCLUSIONS: Citalopram reduces hostile mood responses to social conflict during daily life in dispositionally hostile adults. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
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The efficacy of high-intensity laser and short-wave diathermy both combined with exercises in patients with knee osteoarthritis: a randomized comparative study
The present study aimed to investigate the effects of high-intensity laser therapy and short-wave diathermy, both with exercise, on pain, physical function, and quality of life in patients with knee osteoarthritis and compare the efficacy of these modalities. This head-to-head randomized study included sixty patients diagnosed with primary knee osteoarthritis (OA) according to the American…
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No clinical relevant differences in early clinical outcomes, patient satisfaction and objective gait and posture analysis between a custom versus off-the-shelf total knee arthroplasty: a prospective controlled study
Osteoarthritis is one of the most frequent joint diseases in the world. Therefore, it is critical to develop sufficient therapy strategies to improve a patient’s quality of life. The aim of this study was to evaluate the influence of an individualized (custTKA) vs. a conventional (convTKA) total knee arthroplasty (TKA) in regard to gait, posture…
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Moderately strong intraclass correlations between actigraphic and polysomnographic total sleep time and sleep efficiency in older adults with sleep disturbance
CONCLUSION: Compared to PSG, the GeneActiv actigraphy device provides reliable measurements for total sleep time and sleep efficiency, but agreement was weaker for wake after sleep onset, sleep onset latency, and the number of awakenings. The device showed consistent performance across multiple nights, suggesting good reproducibility. However, it systematically overestimated total sleep time and underestimates…
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A comparative study of sonographic and clinical parameters in patient with upper trapezius muscle trigger point following dry needling and intramuscular electrical stimulation: a randomized control trial
CONCLUSION: It seems that both IMES and DN have promising effects for improving upper trapezius TrPs. However, IMES is more effective in some clinical and ultrasound parameters. In order to investigate the effects of this intervention more precisely more studies are necessary.
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Effect of an herbal gel for the prevention of radiation dermatitis-related symptoms: an open-label randomized clinical trial
CONCLUSIONS: Preventative herbal gel treatment can alleviate the radiation dermatitis-related symptoms with good safety, which indicates that gel could be an option for integration in patient care to improve RT in patients with breast, lung, and head and neck cancers.
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Updated progression-free survival and final overall survival with maintenance olaparib plus bevacizumab according to clinical risk in patients with newly diagnosed advanced ovarian cancer in the phase III PAOLA-1/ENGOT-ov25 trial
CONCLUSION: This post hoc analysis indicates that in patients with newly diagnosed advanced HRD-positive ovarian cancer, maintenance olaparib plus bevacizumab should not be limited to those considered at higher risk of disease progression. Five-year progression-free survival rates support long-term remission and suggest an increased potential for cure with particular benefit suggested in lower-risk HRD-positive patients.
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Comparing visual inspection with acetic acid, with and without Lugol’s Iodine for triage of HPV self-sample positive women in Ethiopia: a randomized controlled trial
CONCLUSION: VIA with iodine improved detection of CIN2+ in women who were hrHPV DNA positive but was not significantly better than VIA alone.