Clinical Trials
Category Added in a WPeMatico Campaign
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Treatment of Intractable Cancer Pain with Resiniferatoxin — An Interim Study
CONCLUSIONS: Intrathecal RTX is a single-administration, opioid-sparing analgesic in patients with intractable cancer pain. There were expected and unexpected AEs of various grades with an encouraging initial impact on pain. (Funded by the Intramural Research Program of the National Institutes of Health Clinical Center and others; ClinicalTrials.gov number, NCT00804154).
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Single-Dose IncobotulinumtoxinA in the Treatment of Early-Stage Knee Osteoarthritis: Results from a Preliminary Single-Arm Clinical Trial
Osteoarthritis (OA) is the most prevalent rheumatologic disease and a leading cause of years lived with disability worldwide. There are no disease-modifying drugs available to treat it. This study aimed to evaluate the effect of a single dose of 100U botulinum neurotoxin-A (BoNT-A) in patients with early knee OA. We designed a single-arm preliminary clinical…
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Is injectable platelet-rich fibrin really effective in alveolar osteitis? a randomised controlled clinical trial
CONCLUSION: I-PRF significantly reduces pain in AO patients compared to conventional treatment. These findings suggest that I-PRF could be a valuable addition to clinical practice, but further studies are needed to confirm its long-term effectiveness.
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Study protocol of a German multi-center, observer-blind, randomized, and actively controlled parallel-group trial comparing maintenance electroconvulsive therapy to treatment as usual for relapse prevention in clozapine resistant schizophrenia
BACKGROUND: Schizophrenia is one of the most severe and costly mental disorders in terms of human suffering and societal expenditure. About 15-30% of patients do not respond to all known antipsychotics, including clozapine, the current gold standard in these cases. Electroconvulsive therapy (ECT) is well-known to be highly effective in clozapine-treatment-resistant schizophrenia (CRS), and synergistic…
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An assessment of the effects of simulation training on management of postpartum hemorrhage: short- and long-term impact on knowledge retention, skills and teamwork in the Democratic Republic of Congo
CONCLUSION: Simulation-based training has a part to play in training healthcare providers to manage post-partum hemorrhage. Training should be repeated after a period of 6 months to enhance knowledge and skill retention.
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Long-term health conditions and their impact on people with sleep disturbances and dementia
CONCLUSIONS: There is a complex relationship between LTCs, dementia and sleep and the effect of LTCs in someone with dementia may be underestimated. It is important that families know that people with dementia need adequate analgesia. In addition, tiredness and illness in family carers may mean they need support to implement strategies, or they will…
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The Impact of Internet Hospital Follow-Up on the Quality of Life of Patients With Epilepsy: Randomized Controlled Trial
CONCLUSIONS: Long-term follow-up through IHs can effectively improve the quality of life and reduce anxiety and depression in patients with epilepsy. This model provides effective support, making it an important tool for managing epilepsy. Therefore, IH management is recommended as a feasible approach for epilepsy follow-up in clinical practice.
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Direct-Access Physiotherapy to Improve Access to Quality Care for Children and Adolescents Presenting to the Pediatric Emergency Department With Musculoskeletal Problems: The PEDPT-MSK Pilot Randomized Control Trial
OBJECTIVE: This pilot study aimed to evaluate the feasibility of conducting a randomized controlled trial (RCT) comparing direct-access physiotherapy for children and adolescents presenting to the pediatric emergency department (ED) with low acuity musculoskeletal complaints, to current usual care provided by a physician alone. DESIGN: Pragmatic parallel 2-arm, single-blinded, single site, feasibility pilot RCT. METHODS:…
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Interpretable noninvasive diagnosis of tuberculous pleural effusion using LGBM and SHAP: development and clinical application of a machine learning model
CONCLUSIONS: This interpretable LGBM-based model provides a reliable, noninvasive tool for TPE diagnosis. It supports clinical decision-making with real-time risk assessment and promises broader applicability through future integration into clinical information systems.
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Effects of Esketamine Versus Remifentanil on Hemodynamics and Prognosis in Patients with Septic Shock Receiving Invasive Mechanical Ventilation: A Randomized Controlled Trial
CONCLUSION: Esketamine may decrease the dosage of norepinephrine in patients with septic shock receiving invasive mechanical ventilation. It is beneficial for stabilizing hemodynamics and appears to be an effective and safe agent for patients with septic shock requiring invasive mechanical ventilation.