Clinical Trials
Category Added in a WPeMatico Campaign
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A randomized controlled trial on the oncologic outcomes of use of the intrauterine manipulator in the treatment of apparent uterine-confined endometrial carcinoma: the MANEC Trial
BACKGROUND: The intrauterine manipulator used during a hysterectomy for endometrial cancer has been suggested as a reason for worsening oncologic outcomes. However, only a few non-randomized retrospective studies have investigated this association.
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Ten sessions of hyperbaric oxygen versus sham treatment in patients with long covid (HOT-LoCO): a randomised, placebo-controlled, double-blind, phase II trial
CONCLUSIONS: 10 HBOT sessions did not show more short-term benefits than placebo for long covid patients. Both groups improved, with a notable sex difference. HBOT has a favourable harm profile.
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Administration of Calcium and Magnesium in Acute Intracerebral Hemorrhage Patients: Assessing Safety and Feasibility
CONCLUSION: Admission serum magnesium levels were found to correlate with hematoma expansion in patients with acute ICH. While magnesium itself may not be a direct therapeutic target, it could serve as a valuable indicator for identifying potential therapeutic strategies aimed at preventing ICH volume increase.
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The effect of calcitriol and cholecalciferol on inflammatory markers in periprocedural myocardial injury: A randomized controlled trial
CONCLUSIONS: Administration of calcitriol was associated with significantly lower levels of hs-CRP, the main cardiac inflammatory marker, in patients undergoing elective PCI. Further clinical studies with a larger sample size are needed to assess the clinical impact of this anti-inflammatory effect.
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Cost-effectiveness of the MiniMed 780G system for type 1 diabetes
CONCLUSIONS: MM780G is likely to be cost-effective vs MDI with isCGM in patients with T1D in the US at a willingness-to-pay threshold of $100,000.
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Short-term structured dietary and exercise interventions delay diabetes onset in prediabetic patients: a prospective quasi-experimental study
CONCLUSIONS: Short-term intervention with SAIDEs exhibited significant anti-inflammatory activity and reduced the prevalence of abnormal blood glucose markers. These benefits persisted even after 6 months of follow-up. However, over the 8-year follow-up period, intensive SAIDEs did not reduce diabetes incidence among prediabetic patients but did delay its onset.
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Ecological Momentary Assessment versus Weekly Questionnaire Assessment of Change in Depression
CONCLUSIONS: Although clinical interviews, questionnaires, and EMA outcomes are related, they assess changes in depression differently. EMA may be more sensitive to intervention effects, but all three methods harbor potential bias, raising validity and reliability questions. Therefore, to enhance the validity and reliability of clinical trial assessments, we emphasize the importance of EMA approaches that…
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Factorial design study of self-management using Dnurse App in T2DM patients
CONCLUSIONS: The diabetes APP has a tendency to improve the HbA(1c) compliance rate of T2DM patients. The APP can help reduce patients’ BP, and patients have a high satisfaction evaluation of the APP. Therefore, the study supports the use of the APP for self-management in people with type 2 diabetes.
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Point of care v/s central lab automated blood culture system in decreasing antibiotic usage in NICU: A randomized controlled trial
BackgroundAntibiotic usage is rampant in NICUs. The time of stoppage of antibiotics depends predominantly on clinical condition of the neonate and final blood culture report. Delay in availability of report due to lab logistics might delay the stoppage of antibiotic. Hence, we hypothesized that having a point of care BACTEC system in NICU premises might…
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Evaluation of a novel elbow joint torque measurement device in healthy subjects and stroke patients: a randomized trial
Current clinical practice lacks quantitative assessment methods for elbow joint movements. In response to existing research limitations, this study introduces the innovative elbow joint torque measurement device (EJTMD), which concurrently measures muscle strength and active range of motion (AROM) using a five-bar linkage system governed by a sliding mode control algorithm. Healthy subjects (n =…