Clinical Trials
Category Added in a WPeMatico Campaign
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Outcomes of autologous bone marrow mononuclear cell administration combined with educational intervention in the treatment of autism spectrum disorder: a randomized, open-label, controlled phase II clinical trial
CONCLUSIONS: Intrathecal BMMNC combined with an educational intervention improved disease severity and adaptability more than education alone in children with ASD.
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Effect of esketamine on postinduction hypotension in elderly patients undergoing elective noncardiac surgery: a secondary analysis of a randomized clinical trial
Postinduction hypotension (PIH) increases the risk of perioperative adverse events. This study aimed to test if low-dose esketamine could significantly decrease the incidence of PIH in elderly patients undergoing elective noncardiac surgery. This was a post hoc analysis of a randomized clinical trial in university-affiliated academic tertiary hospital. Patients (65 to 85 years, ASA physical…
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The efficacy of combined lateral and anterior quadratus lumborum blocks in postoperative pain management following pelvic tumor resection: a randomized controlled trial
CONCLUSION: The ultrasound-guided QLB demonstrated superior analgesic efficacy and reduced morphine consumption compared to patients without the block. Our findings provide evidence supporting the hypothesis that QLB is an effective component of multimodal analgesia for individuals undergoing pelvic tumor resection and reconstructive surgery.
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Changes in Daily Functioning in Association With Tau and Amyloid Among Unimpaired Older Adults With and Without Elevated Amyloid
BACKGROUND AND OBJECTIVES: Everyday functioning declines gradually over time in Alzheimer disease (AD), with the earliest changes potentially occurring at the preclinical stage. We investigated how changes in everyday functioning relate to (changes in) amyloid and tau in a large sample of cognitively unimpaired older adults, most of whom had elevated amyloid levels at the…
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The effect of traditional Thai massage vs routine physical therapy on gait pattern in spastic cerebral palsy: A cross-over randomized controlled trial
CONCLUSIONS: TM has a positive effect on gait performance, as indicated by GPS and increased activity in the right rectus femoris muscle when compared to PT. A large-scale non-inferiority trial is required to affirm the impact of TM.
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Wrist-ankle acupuncture alleviates pain in the acute phase of herpes zoster: A randomized controlled trial
Alternative therapeutic strategies for herpes zoster, especially for acute phase pain relief, are still largely unexplored. This study aimed to compare the effects of wrist-ankle acupuncture combined with standard pharmacological treatment versus standard pharmacological treatment alone in relieving pain in the acute phase of herpes zoster. An open-label, randomized, controlled clinical trial was conducted, enrolling…
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Effectiveness of Self-etching Adhesive Only Versus in Combination with Gluma Desensitizer for Preventing Post-composite Sensitivity — A Prospective Study
CONCLUSION: Subjects belonging to the Gluma desensitizer group reported a statistically significant reduction in postoperative sensitivity to air blast stimuli, following composite restoration, at both 1 week and 1 month follow-up.
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Short-Term Effects of Kinesio Taping on Pain and Functionality in Patients With Cervical Spine Surgery
CONCLUSION: Integrating KT into a CR programme during the early postoperative phase of cervical spine surgery may improve clinical outcomes, specifically in pain intensity, PPT, disability levels and emotional components. However, the addition of KT to the CR programme does not appear to provide any meaningful benefits in terms of functionality compared to the CR…
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Interventional arterial chemotherapy versus sorafenib for advanced hepatocellular carcinoma in China: a health economic evaluation of open-label, randomised, phase 3 study
CONCLUSIONS: HAIC-FO is a more cost-effective treatment for advanced HCC than sorafenib from the Chinese payer’s perspective, particularly in patients with Vp4 PVTT and/or high tumour burden. Further research is needed to explore long-term economic implications and real-world effectiveness data.
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Twenty-year outcomes after repeat doses of antenatal corticosteroids prior to 32 weeks’ gestation: Follow-up of a randomised clinical trial
CONCLUSIONS: In this follow-up of a randomised clinical trial, our data suggest neither major harm nor benefit for the offspring in early adulthood following exposure to repeat dose(s) of antenatal corticosteroids compared with a single course prior to 32 weeks’ gestation. Smaller effects cannot be excluded and follow-up of adult offspring from other trials of…