Clinical Trials
Category Added in a WPeMatico Campaign
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Long-term safety, tolerability, and efficacy of eptinezumab in chronic cluster headache (CHRONICLE): an open-label safety trial
BACKGROUND: Chronic cluster headache is an uncommon but highly debilitating primary headache disorder characterised by excruciating head pain recurring in daily attacks and without remission periods longer than 3 months. Treatment is challenging due to the few strategies available. Eptinezumab, approved for migraine prevention, is a humanised monoclonal antibody that targets calcitonin gene-related peptide, which…
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Comparison of extracorporeal shock wave therapy and high-intensity laser therapy in the treatment of calcaneal spur-related symptoms: clinical outcomes and functional improvement
CONCLUSION: ESWT and HILT are effective non-invasive options for treating calcaneal spur with ESWT providing slightly greater functional benefits.
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Effect of Uncertainty-Aware AI Models on Pharmacists’ Reaction Time and Decision-Making in a Web-Based Mock Medication Verification Task: Randomized Controlled Trial
CONCLUSIONS: Pharmacists’ performance and reaction times varied by AI type and AI accuracy. Overall, uncertainty-aware AI resulted in faster decision-making and acted as a safeguard against bad AI advice to approve a misfilled medication. Conversely, black-box AI had the longest reaction times, and user performance degraded in the presence of bad AI advice. However, uncertainty-aware…
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Adjunctive ketamine vs. buprenorphine in co-occurring major depressive disorder and opioid use disorder: a randomized, double-blind clinical trial assessing anxiety symptom severity and craving intensity
CONCLUSIONS: In conclusion, this randomized clinical trial provides evidence supporting the efficacy of adjunctive Ketamine and Buprenorphine in reducing anxiety symptoms and craving intensity in patients with co-occurring MDD and OUD.
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AI-enhanced guidance demonstrated improvement in novices’ Apical-4-chamber and Apical-5-chamber views
INTRODUCTION: Artificial Intelligence (AI) modules might simplify the complexities of cardiac ultrasound (US) training by offering real-time, step-by-step guidance on probe manipulation for high-quality diagnostic imaging. This study investigates real-time AI-based guidance tool in facilitating cardiac US training and its impact on novice users’ proficiency.
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A study protocol for the CHinA National CancEr screening (CHANCES) trial: a randomized controlled study to compare the screening strategies for lung cancer and colorectal cancer
BACKGROUND: Well-implemented cancer screening strategies can significantly enhance early detection rates, leading to improved treatment outcomes and reduced mortality. However, there remains a paucity of high-quality evidence from developing regions. The CHinA National CancEr Screening (CHANCES) Trial aims to comprehensively evaluate and compare different screening strategies for lung cancer and colorectal cancer (CRC) in the…
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Genomic testing for bleeding disorders (GT4BD): protocol for a randomised controlled trial evaluating the introduction of whole genome sequencing early in the diagnostic pathway for patients with inherited bleeding disorders as compared with standard of care
INTRODUCTION: The current diagnostic pathway for patients with a suspected inherited bleeding disorder is long, costly, resource intensive, emotionally draining for patients and often futile, as half of patients will remain without a diagnosis and be labelled ‘bleeding disorder of unknown cause’. Advances in understanding the genetic basis of the inherited bleeding disorders, coupled with…
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Effectiveness of theory-based breast self-examination intervention for breast cancer prevention among female college teachers in Pakistan: A cluster randomized controlled trial study protocol
BACKGROUND: Breast cancer poses a significant health challenge in Pakistan, with a disproportionately high number of cases diagnosed at advanced stages. Despite the rising incidence, preventative measures like regular screening remain not commonly practiced among Pakistani women. While extensive research exists on breast cancer globally, there is a critical gap in studies specifically designed and…
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A digital therapeutic for people with borderline personality disorder in Germany (EPADIP-BPD): a pragmatic, assessor-blind, parallel-group, randomised controlled trial
BACKGROUND: Fewer than 25% of patients with borderline personality disorder (BPD) receive guideline-adherent psychotherapy. Digital therapeutics can help reduce this gap. Therefore, we tested the effectiveness and safety of priovi, a digital therapeutic for BPD.
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Protocol MelatoSom-Kids-PTSD: sleep disturbances in children and adolescents with post-traumatic stress disorder (PTSD) — a randomized double-blind placebo-controlled trial to investigate the efficacy of paediatric prolonged-release melatonin
Introduction: Sleep disorders in the insomnia spectrum, as well as nightmares, are among the most sensitive and persistent symptoms in children with post-traumatic stress disorder (PTSD). There is currently no reference treatment or specific pharmacological treatment recommendation on the management of sleep disturbances in children and adolescents suffering from PTSD, despite the fact that they…