Clinical Trials
Category Added in a WPeMatico Campaign
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An Educational Video Game in Trauma Triage at Nontrauma Centers: A Secondary Analysis of a Randomized Clinical Trial
CONCLUSIONS: In this process evaluation of a randomized clinical trial, exposure to a theory-based video game was associated with liberalized thresholds for transfer and limited heterogeneity of the estimated treatment effect.
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Could the Hanging Drop Technique Be an Alternative Method to Loss of Resistance in Cervical Epidural Injections?
CONCLUSIONS: The LOR technique was superior to the HD for cervical ILESIs. More studies with larger sample sizes may provide more precise and detailed information.
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Serum C-Terminal Agrin Fragment With Acute and Long-Term Exercise and Angiotensin II Type I Receptor Blockade
CONCLUSIONS: Serum CAF was unaffected by 16 weeks of EX but increased by LOS supplementation. 1EX, performed with one leg, acutely lowered serum CAF, albeit with substantial interindividual variability. These findings collectively identify novel stimuli of serum CAF turnover-drug interaction and time from last exercise bout to blood sampling. These findings add value to CAF…
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Safety and Efficacy of Platelet-Rich Plasma versus Genicular Nerve Radiofrequency Ablation in Knee Osteoarthritis: An Open-Label, Prospective, Randomized, Clinical Trial
CONCLUSION: For patients with chronic knee osteoarthritis, intraarticular platelet-rich plasma therapy may offer superior sustained pain relief and a lower disability index compared to conventional radiofrequency ablation of the genicular nerves.
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Application of Case-Based Learning Combined with PDCA in the Training of Grassroot Surgeons for the Updates in the CSCO Guidelines for the Diagnosis and Treatment of Breast (2023)
CONCLUSION: The study concludes that the integration of the PDCA cycle with CBL significantly enhances the surgeons’ acquisition and application of updated therapeutic knowledge and skills for breast cancer.
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Analytical treatment interruption among women with HIV in southern Africa who received VRC01 or placebo in the Antibody Mediated Prevention Study: ATI stakeholder engagement, implementation and early clinical data
CONCLUSIONS: In a safe, well-tolerated ATI, 18% of 11 African women exhibited post-intervention control. Design and implementation lessons inform future ATIs in Africa. Analyses of peri-acquisition and post-ATI host and viral characteristics can inform the development of interventions for HIV cure, prevention and treatment.
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Effectiveness of stationary cycling with electromyographic biofeedback on neuromuscular control and function in individuals with knee osteoarthritis: a feasibility study
CONCLUSIONS: A six-week cycling program can alleviate pain and enhance knee function. EMG biofeedback of the vastus medialis significantly changed the neuromuscular control in the rectus femoris and vastus lateralis during cycling. Therefore, this study demonstrated that stationary cycling combined with electromyographic biofeedback training can enhance neuromuscular control of the quadriceps and potentially improve functional…
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Effects of deprescribing antidepressants in nursing home residents with dementia-a cluster randomized controlled trial
CONCLUSIONS: The intervention did not significantly reduce antidepressant use among older nursing home residents with dementia. Further optimization and testing in a larger study are needed.
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The effect of therapeutic artistic activities on anxiety and psychological well-being in adolescents with type 1 diabetes: a randomized controlled study
CONCLUSION: It was concluded that therapeutic art activities were effective in reducing anxiety and improving psychological well-being in adolescents with diabetes. It is recommended that therapeutic art activities be integrated into the care programs for children with diabetes.
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Identification of distinct disease activity trajectories in patients with psoriatic arthritis receiving tofacitinib: a post hoc analysis of two phase 3 studies
CONCLUSIONS: In patients with PsA receiving tofacitinib, five distinct trajectory groups were identified with different baseline characteristics and treatment outcomes, but no clear trends in AEs. The tofacitinib 5 and 10 mg twice daily models showed comparable trajectories and baseline characteristics. In patients with HDA, enthesitis and tender joint count may impact timing and/or magnitude…