Clinical Trials
Category Added in a WPeMatico Campaign
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Psychoeducation for Caregivers of Individuals With Borderline Personality Disorder: A Randomized Controlled Trial of Multiple Family Group Therapy
Multiple family group (MFG) therapy is a psychoeducational intervention designed for caregivers of individuals with borderline personality disorder (BPD). This study is the first to compare MFG therapy with treatment as usual (TAU). The objectives were to assess MFG therapy’s impact on caregivers’ social functioning, perceived support from mental health professionals, coping and communication skills…
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Homologous recombination deficiency (HRD) tests for ovarian cancer: a multicenter French phase II study (HERO)
BACKGROUND: The identification of homologous recombination deficient (HRD) tumor is now a crucial step for the therapeutic management of ovarian cancer. The HRD tumors are both sensitive to olaparib maintenance treatment and to platinum-based chemotherapy. Despite the large amount of HRD tests currently available, only a few HRD tests were prospectively validated on a clinical…
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The study on delirium side-effects after ultra-brief pulse electroconvulsive therapy
CONCLUSION: Compared with BP ECT, UBP ECT may reduce the incidence of delirium post-treatment in SCZ without a significant difference in efficacy. The higher cholinesterase levels in the UBP group suggest that UBP ECT may reduce neuronal asynchronous depolarization, cholinergic disorder, and pro-inflammatory responses, thereby reducing the impact on delirium. These findings provide partial scientific…
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Evaluating the efficacy of rumination-focused cognitive-behavioral therapy in alleviating depression, negative affect, and rumination among patients with recurrent major depressive disorder: a randomized, multicenter clinical trial
CONCLUSIONS: Group-based Rumination-Focused Cognitive-Behavioral Therapy (g-RFCBT) demonstrated significant efficacy in reducing the severity of depressive symptoms, rumination, and negative affect among individuals with major depressive disorder (MDD). Moreover, these therapeutic benefits were maintained over a 6-month follow-up period, suggesting durable treatment effects.
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A prospective cluster randomized trial of an interventions bundle to reduce inappropriate antibiotic use for upper respiratory tract infections in the outpatient setting
CONCLUSION: A multi-component intervention can significantly reduce inappropriate antibiotic prescriptions for URTIs in the outpatient setting.
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Impact of the 5A nursing model on immune balance and lymph node metastasis in primary liver cancer patients post-CyberKnife treatment
CONCLUSION: The 5A nursing model significantly impacts immune balance and reduces lymph node metastasis in primary liver cancer patients following CyberKnife treatment. This model enhances CD8 + T cell and NK cell concentrations while reducing Tregs cells, thereby promoting a stronger anti-tumor immune response and ultimately decreasing the rate of lymph node metastasis.
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Effects of a flavonoid-enriched orange juice on antioxidant capacity, lipid profile, and inflammation in obese patients: A randomized placebo-controlled trial
Recent studies underscore the therapeutic potential of citrus polymethoxylated flavonoids-such as tangeretin, sinensetin, and nobiletin-in attenuating inflammation, mitigating oxidative stress, and enhancing metabolic health in individuals with obesity. This randomized, double-blind, placebo-controlled clinical trial assessed the effects of a functional orange juice enriched with flavonoids (200 mL/day) combined with a low-calorie diet over six weeks…
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Application of Multidisciplinary Diagnosis and Treatment (MDT) clinical teaching model in the clinical teaching of some undergraduates of breast diseases in surgery
CONCLUSION: This study pioneers the application of the MDT teaching method in breast cancer clinical education, comparing its efficacy against traditional teaching modes. Findings demonstrate that MDT-based breast cancer diagnosis and treatment education is more efficient and optimized, offering a transformative basis for clinical undergraduate education reform in China. The results advocate for the reconfiguration…
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Cognitive behavioural therapy in comparison to treatment as usual in young adults at high risk of developing bipolar disorder (Bipolar At Risk): a randomised controlled trial to investigate the efficacy of a treatment approach targeted at key appraisal change: Bipolar At Risk Trial II (BART II)
BACKGROUND: Research has demonstrated the ability to identify and treat individuals at high risk of developing psychosis. It is possible to use a similar strategy to identify people who have an emergent risk of bipolar disorder (BD). Interventions during the early phase may improve outcomes and reduce risk of transition. Criteria have been established to…
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Improving the time-efficiency of initial mental health assessment (triaging) using an online assessment tool followed by a clinical interview via phone: a randomised controlled trial
CONCLUSION: The use of online self-report clinical assessment by patients can save time to complete subsequent clinician assessment. Greater time-saving can be expected with better integration of this tool in workflow and increased clinician familiarity with using online self-reported data.