Support Care Cancer. 2025 Dec 26;34(1):56. doi: 10.1007/s00520-025-10274-6.
ABSTRACT
OBJECTIVE: The objective of this study is to investigate the photobiomodulation (PBM) effects when applying blue LED on the grade and severity of radiodermatitis (RD) and analyze the dermatological quality of life of female breast cancer survivors.
METHOD: This is a non-randomized, prospective clinical trial, with 53 women diagnosed with breast cancer undergoing radiotherapy (RT). Participants were divided into a control group (CG; n = 27) and an intervention group (IG; n = 26). The intervention consisted of PBM with blue LED (470 nm) before each RT session, with an energy density of 18.6 J/cm2, energy of 108 J, and power density of 0.06 W/cm2. Data collection was carried out by applying the sociodemographic characteristics form, the Radiation Therapy Oncology Group (RTOG), and the Dermatology Quality of Life Index (DLQI-BRA). The research was approved by the Research Ethics Committee and registered on REBEC.
RESULTS: The RD occurrence was 28% lower (p = 0.039) in the intervention group (n = 11) compared to the CG (n = 19). Dermatological quality of life presents a moderate reduction over time only in the patients in the CG (p = 0.005). This worsening is attributed to increases in the DLQI scores for symptoms and feelings (p = 0.003), daily activities (p = 0.003), and treatment (p = 0.005).
CONCLUSION: The findings suggest that blue LED may be a promising resource to improve the quality of life of patients undergoing RT.
IMPLICATIONS FOR CANCER SURVIVORS: Blue LED may be a sound therapeutic strategy in radiodermatitis management, minimizing radiotherapy negative impacts, consequently improving the quality of life.
PMID:41454020 | DOI:10.1007/s00520-025-10274-6
