Clinical Trials
Category Added in a WPeMatico Campaign
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Effect of a New Skin-Lightening Cosmetic Containing Cordyceps Extract in the Treatment of Melasma: A Clinical Trial
CONCLUSIONS: Our study demonstrated that both oral TXA combined with hydroquinone cream and oral TXA combined with Cordyceps essence significantly improved melasma in women. However, the incidence of adverse reactions was lower with topical Cordyceps essence than that with hydroquinone cream. Cordyceps essence appeared to be a promising alternative for patients intolerant to hydroquinone cream.…
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Efficacy of mailed surveillance invitations and telephone patient navigation to improve hepatocellular carcinoma surveillance uptake: study protocol of VIGILANT-a single-centre, two-arm randomised controlled trial
INTRODUCTION: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality, and mortality rates have continued to rise despite advancements in treatment. Six-monthly ultrasound surveillance is recommended by professional bodies for early detection of HCC in high-risk cohorts. However, surveillance rates remain poor; only 20% of patients attend for regular surveillance. Population health outreach strategies…
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Beyond the jab: Modeling HIV vaccine acceptance in sexual and gender minorities with behavioral economic demand
This study was an investigation of the utility of behavioral economic demand curves (quantitative models showing how consumption changes with price) in assessing acceptance of hypothetical HIV vaccines among sexual and gender minorities (SGMs). Two experiments used simulated purchase tasks (hypothetical scenarios measuring purchasing decisions). SGMs were recruited through Reddit and LGBTQ+ community organizations across…
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Reading through the eyes of a university student: A double-masked randomised placebo-controlled cross-over protocol investigating coloured spectacle lens efficacy in adults with visual stress
BACKGROUND: Visual stress is a reading disorder characterised by perceptual distortions, asthenopia and headache whilst reading, alongside increased sensitivity to repeated striped patterns (‘pattern glare’), in the absence of underlying ocular pathology. Coloured filters including tinted spectacle lenses and coloured overlays/acetates have been reported to ameliorate visual stress symptoms. However, evidence on coloured spectacle lenses…
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Micropore drainage to prevent hematoma in axillary bromhidrosis: A comparative study
Axillary bromhidrosis is characterized by malodor stemming from hyperplastic and hypertrophic apocrine sweat glands. Although surgical excision remains the most definitive treatment, postoperative complications-particularly hematoma-can compromise outcomes and patient satisfaction. This study evaluated the effectiveness of a micropore drainage technique in reducing hematoma and improving overall results. This retrospective comparative study analyzed data from medical…
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Supine position-related obstructive sleep apnea in children: insights from the Childhood Adenotonsillectomy Trial
CONCLUSION: AT is effective in managing childhood OSA regardless of POSA status. The observed dynamic nature of POSA warrants future research into its pathophysiology and natural history.
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Calcitonin and procalcitonin measurement after cholecystokinin-2/gastrin receptor agonist stimulation in patients with advanced medullary thyroid cancer: results from the GRAN-T-MTC study
CONCLUSION: Procalcitonin concentrations after CP04 stimulation were highly correlated with calcitonin concentrations. Unlabeled CP04, if available commercially, may be considered an alternative stimulating agent in MTC patients, even in lower mass amounts. Further studies, including healthy controls, are required to prove this concept and calculate the diagnostic thresholds.
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A mobile supportive care app for patients with metastatic lung cancer: the Lung Cancer App (LuCApp) randomized controlled trial
BACKGROUND: Mobile apps to support the delivery of cancer care are proliferating, often without adequate evidence. Lung Cancer App (LuCApp) is a mobile app developed by researchers, clinicians, and patients to promote real-time monitoring and management of symptoms in patients with lung cancer. We aimed to investigate the effect of LuCApp on health-related quality of…
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Influence of Electro-Acupuncture on Diplopia in Patients With Oculomotor and Abducens Nerves Palsy
BACKGROUND: Diplopia (DP) can have a significant negative impact on one’s quality of life, many clinical investigations lend credence to the notion that acupuncture could be used to treat DP symptoms, randomized controlled trials are lacking, and only clinical observational studies have assessed the effectiveness of acupuncture in managing DP.
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Effectiveness of Pharmacist Interventions in Improving Medication Use in Hospitalised Older Patients Diagnosed With Cardiovascular Diseases: INFAR Before-and-After Study
CONCLUSION: This study emphasises the role of medication reviews by clinical pharmacists in reducing polypharmacy, prescribing omissions, and inappropriate prescribing in older adults with cardiovascular diseases, demonstrating that targeted pharmacist interventions improve medication safety.