Clinical Trials
Category Added in a WPeMatico Campaign
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Graded motor imagery as an adjunct to comprehensive physiotherapy in chronic rotator cuff-related pain: a single blind randomized controlled trial
CONCLUSION: This study highlights that both groups showed significant improvements in pain, range of motion, functionality, and pain-related fear. However, adding GMI therapy led to faster pain relief, better mechanical sensitivity, improved motor imagery skills, and greater treatment satisfaction, warranting further research with larger samples and extended follow-ups to confirm its broader applicability.
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Consumer-Focused Osteoarthritis e-Learning to Complement Physiotherapy Care in People With Knee Osteoarthritis: Protocol for the PEEKO Randomised Controlled Trial
CONCLUSION: This RCT evaluates whether supplementing physiotherapy care with consumer-focused e-learning improves outcomes for people with knee OA.
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Early Neurodevelopment of Extremely Preterm Infants Administered Autologous Cord Blood Cell Therapy: Secondary Analysis of a Nonrandomized Clinical Trial
CONCLUSIONS AND RELEVANCE: This phase 1 nonrandomized clinical trial assessing the safety and feasibility of autologous UCBCs in extremely preterm infants did not find significant differences in brain imaging parameters and early neurodevelopmental outcomes between the cell therapy and contemporaneous untreated groups. It was encouraging to note no infants who received UCBCs were assessed as…
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Balancing Efficiency and Accuracy in Hepatitis C Rapid Antibody Testing: Insights From a Cluster Randomised Crossover Trial
Hepatitis C remains a significant global health problem, particularly among people who inject drugs. To achieve Australia’s 2030 elimination targets, efficient testing strategies are needed. The OraQuick rapid antibody test provides results in 20 min, but many non-viraemic individuals with resolved infections test positive, potentially leading to unnecessary confirmatory RNA testing. Reducing the read time…
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To assess the impact of individualized strategy and continuous glucose monitoring on glycemic control and mental health in pregnant women with diabetes
CONCLUSION: The individualized strategy encompasses an insulin titration protocol guided by CGM, coupled with structured lifestyle modifications that address dietary patterns, physical activity and more, combined with short-term glucose monitoring can exert a positive effect on glycemic improvement in the short term and meet the requirements of glycemic control in pregnancy, which has important clinical…
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Differential effects of dual antiplatelet and dual antithrombotic therapy on hemostasis in chronic coronary syndrome patients: the DEFINE CCS study
Optimal long term antithrombotic treatment in high-risk chronic coronary syndrome (CCS) patients remains uncertain. Both ticagrelor (60 mg BID) and low-dose rivaroxaban (2.5 mg BID) in addition to low-dose aspirin resulted in significant reductions in major cardiovascular events in high-risk patients at the expense of increased bleeding risk. We aimed to compare the effects of…
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Comparison of Postoperative Pain Using Endo-Activator Vs. Conventional Irrigation in Symptomatic Periapical Periodontitis: A Randomised Controlled Trial
CONCLUSION: The intensity and severity of postoperative pain occurring in patients presenting with symptomatic periapical periodontitis was significantly reduced by the use of endo-activator when used with 2.5% NaOCl seven days after single-visit endodontic treatment.
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Effectiveness of three manual toothbrushes with different bristle designs in terms of plaque removal and gingival inflammation: A randomized controlled trial
CONCLUSION: This study showed that the three different toothbrushes were equally effective in plaque removal and reduction of gingival inflammation. The Zigzag toothbrush showed maximum reduction in plaque and gingival inflammation; however, the difference was not significant.
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Effectiveness of an online sexual and reproductive health educational program on knowledge, attitudes, and behaviours among senior primary school students: a cluster randomized controlled trial
CONCLUSIONS: The online sexual and reproductive health educational program significantly improved knowledge, attitudes, and behaviours among senior primary students, providing valuable guidance for school health nurses in designing and implementing sexual and reproductive health education programs.
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Efficacy of methylprednisolone sodium succinate combined with acoustic resonance therapy on inflammatory response indicators and cerebral microcirculation in patients with sudden sensorineural hearing loss
CONCLUSION: The findings suggest that the synergistic application of MPSS and acoustic resonance therapy effectively reduces inflammation and improves cerebral blood flow, leading to better auditory outcomes in patients with SSNHL. This research underscores the potential of integrated treatment approaches in managing SSNHL.