Clinical Trials
Category Added in a WPeMatico Campaign
-
Levels of peripheral CD4 + and CD8 + T cells and glycaemic control level in patients with both type 2 mellitus diabetes and stage III-IV periodontitis: a randomized controlled trial in Chinese population
CONCLUSION: Participants under hyperglycemia (HbA1c ≥ 7.5%) and stage III-IV periodontitis exhibited higher sensitivity of HbA1c level to SRP treatment. When HbA1c ≥ 7.5%, The peripheral CD4+/CD8 + ratio showed a slight increase in the intervention group while only reduction was found in other groups. And the peripheral CD4+/CD8 + ratio of SRP + OHI…
-
Effect of different administration methods of dexamethasone on postoperative pain and swelling following implant flap surgery: A randomized controlled trial of patient-centered outcomes
CONCLUSIONS: Intraoperative submucosal dexamethasone was associated with earlier swelling reduction compared to oral administration, though both methods showed comparable pain control. These findings suggest a potential clinical advantage for the intraoperative route that warrants further investigation.
-
Influences of social support following hip-fracture surgery for older adults with cognitive impairment and their family caregivers
CONCLUSIONS: Good perceived social support positively influenced recovery trajectories for older adults with cognitive impairment and improved HRQoL for both care receivers and caregivers, highlighting the importance of developing targeted interventions to enhance social support during post-surgical recovery for this vulnerable population.
-
Efficacy of combined topical nepafenac 0.3% with suprachoroidal injection of triamcinolone acetonide using a modified custom needle in pseudopkakic cystoid macular edema
CONCLUSION: Combined SCTA using this modified custom needle with topical nepafenac 0.3% resulted in better anatomical and functional results in PCME patients compared to topical nepafenac 0.3% alone. The study was prospectively registered with clinical trial.gov ID (NCT04690608) in 27-12-2020.
-
Impact of wearable-assisted walking on sarcopenia and body composition in older adults
CONCLUSIONS: Wearable devices, such as smartwatches and fitness trackers, provide real-time feedback and enable tailored exercise recommendations, offering a practical and personalized strategy for mitigating sarcopenia. This study confirms that wearable-assisted walking programs effectively improve muscle health and functional performance in older adults, reinforcing their potential for promoting healthy aging.
-
Nicotine e-cigarettes for smoking cessation following discharge from smoke-free inpatient alcohol and other drug withdrawal services: a pragmatic two-arm, single-blinded, parallel-group, randomised controlled trial
BACKGROUND: Nicotine-containing electronic cigarettes (e-cigarettes) have been shown to be effective for smoking cessation among general populations, but there is little evidence in people with substance use disorders (SUDs). We aimed to assess the effectiveness of e-cigarettes for smoking abstinence in people with SUD following discharge from smoke-free inpatient withdrawal services.
-
VIVALDI-CT shaping care home COVID-19 testing policy: A pragmatic cluster randomised controlled trial of asymptomatic testing compared to standard care in care home staff
CONCLUSION: This trial was not well-powered to evaluate the impact of the intervention on the primary outcome, and recorded uptake of staff testing was low. However, our pre-existing care home network underpinned by linked routinely collected data provides a model for more agile interventional studies in the care home setting.
-
Geneva Homologous Recombination Deficiency Test Is Predictive of Survival Benefit From Olaparib and Bevacizumab Maintenance in Ovarian Cancer
CONCLUSION: The Geneva HRD test predicts PFS and OS benefit from olaparib + bevacizumab. The potential detrimental effect of olaparib + bevacizumab on OS in the HRD-negative population is hypothesis-generating and needs to be confirmed prospectively.
-
Effect of the Otago Exercise Program on Activities of Daily Living in Older Adults With Sarcopenia
CONCLUSION: OEP significantly enhances activities of daily living, improves muscle strength, balance, and physical function in older adults, and is more effective than conventional rehabilitation exercise programs, making it suitable for extensive clinical application.
-
Effectiveness of the WeChat-based mini-program («Sober Time ACT») on individuals with hazardous drinking in China: a randomized controlled trial
CONCLUSIONS: These findings provide preliminary prospective evidence that, despite the limitation of high dropout rate, the «Sober Time ACT» mini-program not only effectively reduces alcohol craving and consumption but also improves related psychological indicators to a certain extent, providing an innovative and effective intervention tool for addressing hazardous drinking in China.