Clinical Trials
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Enhanced cognitive outcomes with triple-mode dialysis in kidney failure: role of protein-bound toxin clearance
This study aimed to investigate the effects of different dialysis modalities on cognitive function in patients with end stage renal disease and to explore their association with the clearance of protein bound uremic toxins. A total of 135 patients undergoing maintenance hemodialysis were enrolled and randomly assigned to one of three treatment groups hemodialysis HD…
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Effect of Dual-Task Training on Cognitive Function in Community-Dwelling Older Adults With Mild Cognitive Impairment: Sequential Multiple Assignment Randomized Trial
CONCLUSIONS: This SMART trial established the first evidence-based adaptive intervention framework for community MCI prevention, demonstrating that virtual reality-enhanced Taichi combined with CT produced superior outcomes compared with traditional exercise and control conditions. Treatment intensification proved more effective than modality switching for nonresponders. Diabetes showed a better response enabling personalized intervention selection. These findings provide…
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Effect of the fluid management nursing intervention on improving biochemical test results and dialysis therapy in chronic kidney disease patients: a randomized controlled trial
CONCLUSION: The nursing intervention significantly improved laboratory test results and dialysis adequacy in patients with chronic renal failure and Excess Fluid Volume, highlighting its potential for enhancing patient management and nursing care.
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Incidence of intraocular lens (IOL) tilt and decentration after secondary IOL sulcus implantation versus optic capture in pediatric aphakia
CONCLUSION: Secondary IOL implantation with the capture technique appears to provide a deeper AC and a wider angle than sulcus implantation but could result in greater IOL tilt. UBM discloses changes in IOL position that are not clinically detected during follow-up.
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Efficacy and safety of Ivarmacitinib in moderate-to-severe atopic dermatitis patients with or without previous systemic treatments: a post-hoc analysis of a phase III trial
CONCLUSION: Ivarmacitinib demonstrates good efficacy and a favorable safety profile in moderate-to-severe AD patients, irrespective of previous systemic treatments.
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Fuzuloparib with or without apatinib as maintenance therapy in newly diagnosed, advanced ovarian cancer (FZOCUS-1): A multicenter, randomized, double-blind, placebo-controlled phase 3 trial
Although poly(adenosine diphosphate-ribose) polymerase inhibitors (PARPis) and bevacizumab were approved as first-line maintenance for advanced ovarian cancer (OC), evidence comparing this combination with PARPi monotherapy, especially in BRCA-mutated/homologous recombination-deficient (HRD) patients, is lacking. This study compared combined fuzuloparib (a PARPi) plus apatinib (a vascular endothelial growth factor receptor-2 inhibitor) with either fuzuloparib or placebo as…
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Effectiveness and cost-effectiveness of risk-adapted colorectal cancer screening: a randomized controlled trial and modeling analysis
CONCLUSIONS: In this population-based CRC screening trial, risk-adapted screening, colonoscopy, and FIT demonstrated comparable effectiveness, but differed in participation rates, resource utilization, and cost-effectiveness. Risk-adapted screening could serve as a complementary approach to established strategies, particularly when health resources are limited.
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Economic evaluation of a multi-component obesity prevention intervention in Chinese primary schools
CONCLUSIONS: The DECIDE-Children intervention is a cost-effective strategy for childhood obesity prevention, providing significant public health and economic benefits. Its integration of school, family, and digital components offers a scalable, sustainable model for addressing childhood obesity in China and other developing settings.
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Effects of kefir on symptoms, sleep, and gut microbiota in children with ADHD: a randomised controlled trial
CONCLUSIONS: Kefir supplementation may support modest improvements in sleep quality, in children with ADHD. These findings contribute to our understanding of the potential role of nutrition in ADHD management and may inform clinical guidance for practitioners working with neurodivergent individuals.
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Clinical efficacy of integrated 3D manual pelvic reduction, suspension training, and pelvic belt fixation for postpartum pubic symphysis diastasis
CONCLUSION: The combined protocol of 3D pelvic reduction, suspension training, and pelvic belt fixation effectively alleviates pain, restores pelvic alignment, enhances functional recovery, and improves QoL in postpartum PSD patients, representing a potentially promising therapeutic strategy for clinical adoption.