Clinical Trials
Category Added in a WPeMatico Campaign
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Artificial Intelligence in Depression-Medication Enhancement (AID-ME): A Cluster Randomized Trial of a Deep-Learning-Enabled Clinical Decision Support System for Personalized Depression Treatment Selection and Management
Background: There has been increasing interest in the use of artificial intelligence (AI)-enabled clinical decision support systems (CDSS) for the personalization of major depressive disorder (MDD) treatment selection and management, but clinical studies are lacking. We tested whether a CDSS that combines an AI which predicts remission probabilities for individual antidepressants and a clinical algorithm…
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Efficacy of Heel Lifts for Managing Midportion Achilles Tendinopathy (The LIFT Trial): A Participant- and Outcome Assessor-Blinded Randomized Controlled Trial
OBJECTIVE: To evaluate the efficacy of heel lifts in people with midportion Achilles tendinopathy. DESIGN: This was a parallel-group randomized, sham-controlled, participant- and assessor-blinded trial conducted at a single center (Victoria University, Institute for Health and Sport, Melbourne, Australia). METHODS: One hundred and eight participants (38 females and 70 males; mean age, 48 years; standard…
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Comparative Analysis of Cardiac CT and Invasive Coronary Angiography for Suspected Stable Coronary Artery Disease and Subsequent Functional Testing and Revascularization: A Prespecified Secondary DISCHARGE Randomized Trial Analysis
Purpose To compare functional testing and management after cardiac CT-first versus invasive coronary angiography (ICA)-first strategies in participants with stable chest pain and low to intermediate probability of obstructive coronary artery disease (CAD) initially referred for ICA. Materials and Methods This study was a prespecified secondary analysis of the prospective, multicenter, randomized DISCHARGE (Diagnostic Imaging…
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Adding L-Carnitine and Selenium to Methimazole in Graves’ Disease: A Prospective Randomized Trial on Thyroid Markers and Quality of Life
Background: The therapeutic response in Graves’ Disease (GD) remains largely unpredictable. Patients often experience persistent symptoms that are poorly correlated with thyroid hormone levels, an undefined treatment duration, and the need for long-term or definitive therapies. Based on the nuclear antagonistic properties of L-carnitine (LCT) on thyroid hormone action and the immunomodulatory role of selenium…
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Effect of myofascial release therapy applied to selective muscles on mobility and function in patients with temporomandibular dysfunction and co-occurring chronic low back pain: A randomized controlled trial
CONCLUSIONS: MFR therapy was effective in reducing symptoms of TMD and LBP-related disability and demonstrated greater benefit than exercise therapy in most outcome measures. The observed parallel improvements suggest a biomechanical and neuromuscular link between the jaw and lumbar region, supporting the integration of MFR in interdisciplinary rehabilitation for patients with comorbid TMD and LBP.
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Enhancing clinical skills education through scenario-based simulation with debriefing: A randomized controlled study on bone marrow aspiration training
CONCLUSION: Debriefing-based simulation teaching improves teaching quality, clinical performance, learning motivation, and diagnostic thinking, and is broadly applicable in clinical skills education.
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Evaluation of patients diagnosed with chronic obstructive pulmonary disease in terms of treatment compliance and quality of life after follow-up with telemedicine: a randomized controlled trial
CONCLUSIONS: Telemedicine has improved the quality of life of advanced-stage COPD patients and their inhaler techniques. It may, therefore, be considered a promising alternative to traditional face-to-face follow-ups, although various technical infrastructures and legal regulations are necessary.
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Psychometric properties of the German Stroke and Aphasia Quality of Life Scale 39 generic version
CONCLUSIONS: The German SAQOL-39g is a reliable, valid and change-sensitive patient-reported outcome measure to assess the physical, communication and psychosocial quality of life in chronic post-stroke aphasia, with comparable psychometric properties and factorial structure to the original English version.
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Sennosides vs magnesium hydroxide vs polyethylene glycol as a treatment for constipation in anorectal malformation: a randomized crossover trial
CONCLUSION: While PEG showed a trend towards better fecal clearance and Sennosides was preferred by users, no statistically significant differences in efficacy or user preference were found among the three laxatives.
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Regulation of Somatosensory Temporal Discrimination Threshold Through Motor Training: An EEG and Kinematics Study
CONCLUSION: Actual execution (BRT) and motor imagery (VGI) enhance STDT through distinct neuroplastic mechanisms: BRT optimizes sensorimotor integration via parietal gamma/prefrontal theta oscillations, while VGI relies on ipsilateral parietal delta modulation. These findings underscore the role of cortical reorganization in motor learning and support tailored rehabilitation strategies for neurological disorders.