Clinical Trials
Category Added in a WPeMatico Campaign
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THE IMPACT OF HYALURONIC ACID ON GINGIVITIS AND PERIODONTAL HEALTH
Gingivitis is a reversible inflammatory condition of the gingival tissues, primarily initiated by microbial plaque accumulation. The present study aimed to assess the therapeutic efficacy of 1% hyaluronic acid (HA) gel as an adjuvant remedy to standard scaling and polishing procedures (SPP) in the management of gingivitis. Twenty systemically healthy adults diagnosed with gingivitis were…
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The high-dose dual therapy for eradication of Helicobacter pylori: efficacy and safety
CONCLUSION: The efficacy of the Era-RebAmIPP regimen is comparable to conventional triple therapy with bismuth. To assess the effectiveness of this regimen, larger-scale studies are required in various regions of our country.
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Study on the efficacy of combination therapy with rifaximin and Saccharomyces boulardii CNCM I-745 in patients with small intestinal bacterial overgrowth associated with long-term use of proton pump inhibitors
CONCLUSION: This prospective comparative study demonstrates that combination therapy with rifaximin and Saccharomyces boulardii CNCM I-745 appears more effective than rifaximin monotherapy for SIBO eradication, symptom regression, and QoL improvement in patients with PPI-associated SIBO.
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Return to normal activity after abdominal surgery: a pre-planned secondary analysis of a randomised controlled trial across seven low- and middle-income countries
CONCLUSIONS: With rising need for surgical care and non-communicable disease globally, this study highlights the groups of patients at critical need for improving return to normal activity or recovery after surgery in LMICs. Improving access and implementation of rehabilitation pathways, aligned to the World Health Organisation, may be crucial to improve financial risk protection to…
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Comparative evaluation of the effects of diclofenac sodium and vitamin D supplementation on symptoms in individuals with myofascial pain and vitamin D deficiency: a randomized controlled clinical trial
CONCLUSIONS: Vitamin D may serve as an alternative with anti-inflammatory and analgesic effects compared to NSAIDs.
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Efficacy and safety of pilocarpine hydrochloride ophthalmic solution USP 1.25% w/v versus placebo ophthalmic solution for the treatment of presbyopia — A multicentric clinical trial
CONCLUSION: Pilocarpine 1.25% effectively improves near vision in presbyopia, with sustained benefits up to day 30 and potential long-term adaptability.
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Atrial fibrillation burden and symptom, quality of life, and healthcare resource utilization after cryoballoon ablation in persistent atrial fibrillation
CONCLUSION: In early persistent AF, lower AF burden 1-year post-CBA was associated with greater AF-related symptom improvement, significant QoL enhancement, and reduced HCRU during follow-up.
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Integrating breast cancer polygenic risk scores at scale in the WISDOM Study: a national randomized personalized screening trial
CONCLUSIONS: In a first-in-kind application of PRS to inform breast cancer screening approaches, we demonstrate feasibility for scaled implementation, moderate changes to individual screening recommendations, and minimal projected downstream burden on the healthcare system.
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A comparative analysis of heterogeneity in lung cancer screening effectiveness in two randomised controlled trials
Clinical trials demonstrate that screening can reduce lung cancer mortality by over 20%. However, lung cancer screening effectiveness (reduction in lung cancer specific mortality) may vary by personal risk-factors. Here we evaluate heterogeneity in lung cancer screening effectiveness through traditional sub-group analyses, predictive modelling approaches and machine-learning in individual-level data from the Dutch-Belgian lung cancer…
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Effect of perioperative music on delirium after hip fracture operations (MCHOPIN): a multicentre randomised clinical trial in Dutch hospitals
CONCLUSIONS: This study suggests a positive effect of music interventions on postoperative delirium, which provides additional evidence for considering the implementation of these interventions in hip fracture care.