Clinical Trials
Category Added in a WPeMatico Campaign
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A public health perspective on virtual reality interventions: exploring the impact of VR extreme sports on stress, anxiety, and depression in men with social anxiety disorder
CONCLUSION: These findings highlight the promise of VR-based extreme sports as a novel, non-pharmacological intervention for men with SAD. By enabling controlled exposure to anxiety-provoking situations within a safe and immersive environment, the intervention effectively alleviated symptoms of depression, anxiety, and stress. Moreover, this approach may overcome common treatment barriers such as stigma and reluctance…
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Pilot Trial of SDX/d-MPH Adult ADHD Examining Effects Throughout the Day
CONCLUSIONS: This pilot study is the first systematic treatment effect trial data for SDX/d-MPH in adults with DSM-5 ADHD. The data preliminarily supports the clinical efficacy of DSM/d-MPH in adult ADHD and its ability to ameliorate symptoms throughout the day.
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Heel kicking exercise rapidly improves pain and function in patients with acute lateral ankle sprain: a randomized controlled trial
CONCLUSIONS: HKE is a method designed to provide rapid movement rehabilitation for patients with ankle sprains, which can be used as one of its basic treatments.
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Effectiveness of a web-based decision aid for patients with Generalised Anxiety Disorder in Spain: a randomised controlled trial
CONCLUSION: The use of the PtDA led to improvements in knowledge at 3 months, but it did not result in a significant reduction of decisional conflict. These results must be interpreted with caution, given the methodological limitations of the study, mainly the high rate of dropouts. Further research is needed to confirm these results, the…
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The Effect of Patient Safety Education Through a Peer Education Model on Patient Safety Competence and Medical Error Attitudes of Nursing Students: A Randomized Controlled Study
CONCLUSION: Peer education improved sensitivity to medical errors but was less effective in ensuring knowledge retention. A discrepancy was identified between attitudes and practical application of patient safety knowledge, with students expressing low confidence in applying theoretical knowledge in practice. [J Nurs Educ. 2025;64(7):407-414.].
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MovingTogether: a randomised controlled trial of a mental-health-informed, digital health promotion intervention for older adults
CONCLUSION: The results suggest multicomponent digital health promotion interventions, combining lifestyle education, physical activity and social support, can improve the mental health of older adults. More research is needed to understand how to best utilise digital engagement strategies and improve retention in physical activity programmes for older adults.
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Remote monitoring of patients with NYHA functional class II-III chronic heart failure using the M-Cardio mobile application in residents of Kyrgyzstan
Aim Development and implementation of the M-Cardio mobile application for remote monitoring of patients with chronic heart failure (CHF) at the outpatient stage with an assessment of clinical effectiveness.Material and methods This study included 244 patients with NYHA functional class (FC) II-III CHF of ischemic etiology. During the inpatient phase, the patients were taught the…
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Effect of sumatriptan on ATP-sensitive potassium channel opening in migraine: A randomised controlled trial
ObjectiveTo investigate whether early administration of sumatriptan prevents migraine induced by ATP-sensitive potassium (K(ATP)) channel opener levcromakalim.MethodsThis single-centre, randomised, double-blind, placebo-controlled, two-way crossover study included adults with migraine without aura. Participants received a 20-minute intravenous infusion of levcromakalim on two separate occasions, followed immediately by a 10-minute intravenous infusion of either sumatriptan or placebo (isotonic…
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Comparison of intravenous nalbuphine and sufentanil on the median effective effect-site concentration of propofol to attenuate the response to cervical dilation during hysteroscopy: a double-blind, dose-response study
CONCLUSIONS: During hysteroscopic surgery, when compared with sufentanil, 0.2 mg·kg^(-1) nalbuphine significantly reduced the EC(50) for propofol to inhibit cervical dilation response and the propofol requirement, and did not delay the emergence from anesthesia. Whether 0.2 mg·kg^(-1) nalbuphine could improve perioperative prognosis is worthy of further studies.
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Design and protocol for the decompression-plus trial: a phase 1 clinical study of dorsal myelotomy and expansive duroplasty with or without autologous nerve grafting in acute traumatic spinal cord injury
CONCLUSION: DMED with or without ANGI represent novel interventions for managing acute tSCI. The results of this phase 1 trial will determine whether these interventions can be performed safely and feasibly in a consecutive cohort of patients to potentially enhance recovery and improve outcomes.