Clinical Trials
Category Added in a WPeMatico Campaign
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Laser treatment for temporomandibular disorder: a randomized controlled clinical trial
This study aimed to assess the impact of photobiomodulation therapy (PBMT) using low-level laser therapy, an occlusal splint (OS), and their combined application (OSL) on symptoms of muscular temporomandibular disorder (TMD) through a randomized clinical trial. Participants diagnosed with muscular TMD following the Diagnostic Criteria for TMD guidelines were allocated to three groups: OS, L,…
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Effect of 0.8% Hyaluronic Acid-Based Gel on Clinical and Biomolecular parameters in the surgical periodontal treatment of Stage III periodontitis patients: a randomized, split-mouth clinical trial
CONCLUSION: The local application of 0.8% HA gel with OFD provides to beneficial effect GCF IL-10 and IL-17 A levels in severe periodontitis patients.
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Quantitative Multi-Parameter MRI Evaluation of Hashimoto’s Thyroiditis Changes After Dietary Interventions
BACKGROUND Hashimoto’s thyroiditis is a common autoimmune disease. There are currently few studies utilizing multi-parametric magnetic resonance imaging (MRI) to investigate diffuse thyroid lesions such as Hashimoto’s thyroiditis. This study aims to explore the value of multi-parametric MRI in assessing the progression of Hashimoto’s thyroiditis. MATERIAL AND METHODS The study ultimately included 40 patients with…
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Randomized Cross-Over Analysis of the Influence of Nitrogen Multiple Breath Washout on Spirometry in Monitoring Lung Function in Patients With Cystic Fibrosis and Primary Ciliary Dyskinesia
BACKGROUND: When monitoring lung function in patients with Cystic Fibrosis (pwCF) and Primary Ciliary Dyskinesia (pwPCD), nitrogen multiple breath washout (N(2)MBW) is usually performed before spirometry to prevent forced expiratory maneuvers from altering N(2)MBW results. The N(2)MBW may affect spirometry if cooperation decreases after a long period of examination or due to prolonged oxygen inhalation.…
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Effect of simvastatin on expression of Interleukins 6 & 10 and Matrix Metalloproteinase: 9 when used as an intracanal medicament in teeth with symptomatic apical periodontitis-a triple blind randomized controlled trial
CONCLUSIONS: The expression of these biomarkers indicates that simvastatin is effective in reducing inflammation and pain in teeth with pulpal necrosis and symptomatic apical periodontitis when used as an intracanal medicament compared to Ca(OH)₂.
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The impact of a love language game intervention on relationship satisfaction among Chinese couples in China and Malaysia: examining the role of individualism-collectivism
CONCLUSION: This study contributes to the literature on love language-based interventions and their application in culturally diverse settings, offering valuable insights for relationship counsellors, educators, and policymakers. The findings may guide the development and implementation of culturally sensitive interventions to enhance relationship satisfaction and overall well-being in diverse populations.
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LODESTAR: A Single-Arm Phase II Study of Rucaparib in Solid Tumors With Pathogenic Germline or Somatic Variants in Homologous Recombination Repair Genes
CONCLUSION: Rucaparib has activity in HRDsig+ solid tumors with PVs in homologous recombination repair genes, regardless of histology. Platinum sensitivity correlated with improved outcomes.
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Device-Based Physical Activity and Low-Grade Inflammation in People With Multimorbidity: Cross-Sectional Baseline Analysis From the MOBILIZE Trial
Physical activity (PA) has anti-inflammatory effects, but its impact on individuals with multimorbidity (two or more chronic conditions) is unclear. We examined the association between device-measured (i.e., accelerometers) PA and inflammatory biomarkers in people with multimorbidity. In a, preplanned, cross-sectional analysis from the MOBILIZE trial, 214 participants with multimorbidity provided data on PA and inflammatory…
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Safety and Efficacy of Reduced-Port Versus Conventional Laparoscopic Distal Gastrectomy for Early Gastric Cancer: A Multicenter, Randomized, Non-inferiority Trial (KLASS-12)
CONCLUSIONS: RPLG is a feasible and safe alternative for patients with EGC, and its short-term outcomes are not inferior to those of CPLG.
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Gamified Telerehabilitation in Oligoarticular Juvenile Idiopathic Arthritis: A Randomized Controlled, Single-Blind Trial
CONCLUSION: The 6-week gamified telerehabilitation program reduced pain symptoms and kinesiophobia behaviors while improving the participants’ quality of life and mobility.