Clinical Trials
Category Added in a WPeMatico Campaign
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The effect of exercises done with virtual reality glasses on pain, daily life activities, and quality of life of individuals with lumbar disc hernia: a randomized controlled trial
CONCLUSION: Virtual reality -based exercises effectively reduced pain, improved daily activities and quality of life, and decreased fall risk in lumbar disc herniation patients, suggesting their potential as a complementary rehabilitation approach. Blinding was not applied due to the nature of the interventions, which may introduce a potential risk of bias.
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Comparison of three different puncture techniques for endobronchial ultrasound transbronchial needle aspiration: a single-center, prospective, randomized controlled study
CONCLUSIONS: All three EBUS-guided puncture techniques exhibited high diagnostic accuracy and low bleeding risk, with no statistically significant differences observed. These findings suggest that technique selection may depend on operator preference or the clinical context rather than superiority in diagnostic performance.
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Effect of percutaneous release versus steroid injection among adults with trigger fingers: a randomized clinical trial
CONCLUSION: Percutaneous release of A1 pulley illustrated greater improvement in functional mobility with a moderate effect size and pain with a large effect size compared to steroid injection in trigger fingers. A multicenter trial with a larger sample size and involving a diverse participant cohort may enhance the strength of the evidence.
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Efficacy of probiotic co-supplementation with omega-3 PUFAs on pancreatic beta-cell function in type 2 diabetes
The current understanding of the beneficial effects of probiotics in type 2 diabetes (T2D) relies on both animal and clinical data, which focus mainly on their impact on insulin resistance. The use of high-dose omega-3 polyunsaturated fatty acid (PUFA) therapy has been well tolerated in pilot trials and could have a positive effect on the…
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In vivo analysis of conservation of tooth structure using conventional method, loupes, and dental operating microscope — A randomized clinical trial
CONCLUSION: Magnification-assisted endodontics significantly improves the precision of access cavity preparation. While the DOM offers optimal dentin conservation and enhanced canal orifice detection, surgical loupes strike a balance between improved visualization and procedural efficiency. The integration of magnification tools in pediatric endodontics will surely enhance clinical outcomes, although practical considerations such as cost, training, and…
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Good Outcome Following Attempted Resuscitation Score and Clinical Frailty Scale for Estimating Long-Term Mortality: An Ancillary Study of the CLEAR Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this ancillary study of the CLEAR trial, the GO-FAR score and CFS effectively estimated long-term all-cause mortality, particularly when combined with the CCI. These tools may help clinical decision-making, resource allocation, and advanced care planning in aging, multimorbid patient populations.
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Health Care Professional Willingness to Treat Opioid Use Disorder vs Type 2 Diabetes in Primary Care
CONCLUSIONS AND RELEVANCE: These findings suggest that PCPs have positive attitudes toward treating OUD yet more willingness to treat type 2 diabetes in primary care. Future implementation studies are needed to support MOUD prescribing in primary care.
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Colorectal Cancer and Advanced Adenoma after Single CT Colonography or Biennial FIT Screening in the SAVE Randomized Controlled Trial
Background A 5-year screening interval for CT colonography (CTC) and a 2-year screening interval for fecal immunochemical tests (FITs) have been recommended on the basis of the natural history of colorectal cancer (CRC). Purpose To assess whether the recommended 5-year interval for screening CTC is appropriate and whether CTC is associated with earlier diagnosis relative…
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Brain Frailty and Functional Outcomes After Thrombolysis for Acute Ischemic Stroke
CONCLUSIONS AND RELEVANCE: In this cohort study of patients with AIS treated with intravenous thrombolysis, brain frailty markers-particularly white matter changes, cortical atrophy, and total brain frailty-were associated with worse outcomes. Consideration of these neuroimaging markers may better inform clinicians and patients about treatment expectations from thrombolytic therapy.
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Comparison of cheese with and without Propionibacterium freudenreichii subsp. shermanii LMGT 2951 on off-season muscle strength and VO(2) max development in Nordic skiers: a randomized clinical trial
CONCLUSION: Both Jarlsberg cheese, characterized by its unique Propionibacterium freudenreichii content, and Norvegia cheese, when combined with off-season training, led to increases in LBM, VO₂ max, and MS, with no significant differences observed between groups. However, there was a trend toward greater improvements in MS in the Jarlsberg group. Overall, increases in LBM through structured…