Clinical Trials
Category Added in a WPeMatico Campaign
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A Risk Stratification Model for Predicting Benefits of Intensive Blood Pressure Treatment: Analysis of the Systolic Blood Pressure Intervention Trial
Current hypertension guidelines lack personalized strategies for blood pressure control. While the Systolic Blood Pressure Intervention Trial (SPRINT) demonstrated benefits of intensive blood pressure lowering, identifying optimal candidates for such treatment remains challenging. We developed and validated a risk stratification model using data from 9139 SPRINT participants. The model incorporated 11 clinical variables through multivariable…
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Three-dimensional multiple object tracking (3D-MOT) performance in young soccer players: Age-related development and training effectiveness
CONCLUSIONS: This research provide evidence that the 3D-MOT performance of young soccer players exhibits an increase between 13 and 15. Moreover, the results showed a significant training improvement in youth soccer players, but there was no significant relationship between the age-related development of 3D-MOT and the training effect in young soccer players. The above results…
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Low Testosterone Level and Mortality Risk in Patients With Prostate Cancer: A Post-Randomization Analysis
CONCLUSION: Unlike PSA, multiparametric MRI (mpMRI) images are not influenced by the serum testosterone level; therefore, evaluating whether PCSM can be reduced by incorporating mpMRI into PC-screening in otherwise healthy men or transgender women with a low serum testosterone level should be considered.
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Efficacy of Botulinum Toxin A for the Management of Melasma: A Split-Face, Randomized Control Study
CONCLUSION: Intradermal incoBoNT-A injection combined with TCC demonstrated superior efficacy in melasma treatment and recurrence prevention compared to TCC monotherapy.
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Long-term effect of CoDuSe program on balance, fall risk, and gait in patients with multiple sclerosis
CONCLUSION: The CODuSe program, when combined with a standard exercise routine, has a long-lasting effect on balance, fall risk (up to 24 weeks), and gait ability (up to 16 weeks) in patients with MS.
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Effects of integrating Feldenkrais method with dynamic neuromuscular stabilization exercises on clinical outcomes in older women with nonspecific chronic low back pain: A randomized controlled trial
CONCLUSION: Both interventions effectively alleviated pain and fear of movement while enhancing lumbar range of motion in older women with chronic low back pain. The combined intervention, integrating the Feldenkrais Method with Dynamic Neuromuscular Stabilization exercises, yielded superior clinical outcomes, supporting its incorporation into rehabilitation programs to improve functional independence and quality of life.
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The role of probiotics and dietary interventions in the treatment of periodontitis: a pilot randomized controlled clinical trial
CONCLUSION: Probiotics were found to support periodontal healing, and this effect was significantly enhanced by a personalized anti-inflammatory diet. It is recommended that probiotics and balanced nutrition be integrated into a holistic approach in the treatment of periodontitis.
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Immediate efficacy of low-intensity focused ultrasound versus planar ultrasound in patients with myofascial pain syndrome of upper trapezius: a randomized controlled clinical trial
CONCLUSION: Both LIFU and LIPU can be considered effective therapeutic options, offering immediate symptom relief in patients with upper trapezius MPS.
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Distress screening in patients with high-grade glioma: diagnostic accuracy in relation to a structured clinical interview in a multicenter cluster-randomized controlled trial
CONCLUSION: While all three tools performed better than random chance, none demonstrated convincing discriminative ability in identifying psychiatric comorbidities. In practice, screening tools can identify a substantial proportion of patients with mental disorders, however at the cost of a considerable number of false negatives.
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Impacts of acupuncture and moxibustion combined with ABCLOVE voice training on voice function and inflammatory factor levels in patients with vocal cord polyp operation
Objective:To explore the impacts of acupuncture and moxibustion combined with ABCLOVE voice training on voice function and the levels of inflammatory factors in patients who were diagnosed with vocal cord polyp and received operation. Methods:A total of 96 cases who received operation on vocal cord polyp were randomly assigned into two groups. The control group…