Clinical Trials
Category Added in a WPeMatico Campaign
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A multicenter phase 2 trial in children and young adults with newly diagnosed T-ALL: ALL-T11/ T-ALL-211-U from the Japan Children’s Cancer Group and the Japan Adult Leukemia Study Group
T-cell acute lymphoblastic leukemia (T-ALL) accounts for approximately 10-15% of childhood ALL, with its incidence increasing during the adolescent and young adult (AYA) period. The Japan Children’s Cancer Group (JCCG) and the Japan Adult Leukemia Study Group (JALSG) conducted the ALL-T11/T-ALL-211-U clinical trial in newly diagnosed T-ALL patients under 25 years of age. The treatment…
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Induction therapy with bortezomib, melphalan, and prednisone followed by lenalidomide and dexamethasone versus carfilzomib, lenalidomide, and dexamethasone with or without daratumumab in older, fit patients with newly diagnosed multiple myeloma (GEM-2017FIT): a phase 3, open-label, multicentre, randomised clinical trial
BACKGROUND: Triplet and quadruplet regimens based on bortezomib, melphalan and prednisone (VMP) and lenalidomide and dexamethasone (Rd) with anti-CD38 antibodies are potential treatments for transplant-ineligible patients with newly diagnosed multiple myeloma. However, the high risk of toxic effects in this population requires frailty-based therapy adaptation. We aimed to compare the response of carfilzomib-based triplet and…
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Blending electronic techniques with traditional teaching methods to enhance chest X-ray interpretation in medical students
CONCLUSION: Both traditional and blended E-learning improved students’ chest x-ray interpretation skills. However, the study found that the group receiving electronic training showed more noticeable positive changes, significantly increasing students’ self-confidence. A combination of E-learning and traditional methods significantly improves chest radiograph interpretation among young students. Early integration of E-learning for CXR interpretation in the…
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Addiction Consult Services, Mortality, and Acute Care Utilization in Inpatients With Opioid Use Disorder: A Secondary Analysis of a Cluster Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this prespecified secondary analysis of a cluster randomized clinical trial, postdischarge ED visits decreased with the CATCH program, highlighting the potential of hospital-based addiction consult services to address needs of patients with opioid use. Nonetheless, high rates of acute care utilization and mortality persisted, underscoring the need for comprehensive care strategies…
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Early Change in Depressive Symptom Severity With Naltrexone-Bupropion Combination and Its Association With Reduction in Methamphetamine Use in ADAPT-2 Trial
Objective: This study evaluated whether depressive symptom severity improved early with extended-release naltrexone and bupropion combination (naltrexone bupropion) compared to a placebo in individuals with moderate/severe methamphetamine use disorder and predicted subsequent use of methamphetamine.
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Efficiency of remote monitoring and guidance in blood pressure management: a randomized controlled trial : The role of remote monitoring in improving hypertension management
CONCLUSIONS: Remote monitoring and guidance enhanced the efficiency of BP management, whereas self-monitoring alone proved to be ineffective.
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Mom Supporting Mom: Effective Peer Support Intervention for Women with Postpartum Psychological Distress
Objective: Untreated perinatal mental health disorders can have serious consequences for the whole family system. The purpose of this study was to examine the effectiveness of peer support intervention in improving postpartum psychological distress. Method: We evaluated a remote peer support intervention, Mom Supports Mom, in a randomized controlled trial. The primary study outcome was…
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Acceptability and implementation potential of a health literacy intervention to increase colorectal cancer screening in deprived areas: A qualitative study of patients and general practitioners participating in a cluster randomized controlled trial
CONCLUSION: Our findings emphasize the need to tailor promotional materials for both patients and healthcare professionals to improve CCR screening uptake, balancing digital efficiency with maintaining core human relationships in healthcare. Such intervention can be integrated into different workflows. The addition of video into national CRC screening programs might also help. Targeting CRC screening interventions…
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The Impact of Clustered Care on Itch Severity and Sleep Quality in Patients with Atopic Dermatitis via an Online Platform
This study investigated the efficacy of clustered care delivered via an online platform for adult atopic dermatitis patients. Ninety-eight atopic dermatitis patients from the Second Hospital of Hebei Medical University (May 2022-May 2024) were randomly assigned to a study group (online clustered care) or a control group (routine care), with 49 in each. Outcomes, including…
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Guided Internet-Based Cognitive Behavior Therapy for Women With Bulimia Nervosa: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, the intervention group experienced a significant decrease in bulimia symptoms compared with the control group, supporting the effectiveness and acceptability of the therapist-guided ICBT program. These findings suggest that integration of therapist-guided ICBT in usual care has the potential to improve accessibility to efficacious treatment options for…