Clinical Trials
Category Added in a WPeMatico Campaign
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Clindamycin Phosphate 1.2%/Adapalene 0.15%/ Benzoyl Peroxide 3.1% Gel for Moderate-to-Severe Acne: A Pooled Analysis by Age
CONCLUSIONS: Fixed-dose, triple-combination CAB gel was efficacious and well tolerated in participants with moderate-to-severe acne, regardless of age. Approximately half of the participants achieved clear/almost clear skin, with >70% reductions in lesion counts.
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Efficacy and safety of topical GT20029 in male patients with androgenetic alopecia: a multicenter, randomized, double-blind, placebo-controlled phase 2 study
CONCLUSION: Topical GT20029 demonstrated significant efficacy in hair regrowth with good tolerability. Further studies are warranted to confirm its therapeutic potential in AGA.
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Modulating the lung-gut axis: A randomized controlled trial of Xie Bai Zeng Ye decoction on intestinal flora and mucosal immunity in children with post-infectious cough
CONCLUSION: This exploratory study suggests that XBZY may be a promising treatment option for children with post-infectious cough characterized by lung heat and Yin deficiency. Compared with Montelukast Sodium, XBZY demonstrated superior short-term improvements in cough resolution, symptom relief, quality of life, intestinal barrier function, and gut microbiota modulation, while maintaining good safety. These findings…
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Abdominal massage as an adjunctive therapy for pediatric functional constipation: a randomized controlled trial
CONCLUSION: A 12-session abdominal massage therapy program appears to be an effective adjunct treatment to standard pharmacological therapy for alleviating constipation-related symptoms in children. Larger, multicenter trials are needed to confirm these findings.
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Comparative evaluation of safety and efficacy of dapoxetine, silodosin, and citalopram in the management of premature ejaculation: a randomized clinical trial
CONCLUSION: In this direct head-to-head comparison of active treatments for lifelong PE, daily citalopram (20 mg) demonstrated superior efficacy in prolonging IELT and improving psychosocial outcomes compared to daily or on-demand dapoxetine and silodosin. The findings suggest that citalopram is a highly effective first-line option, while the dose-dependent efficacy of dapoxetine and the distinct side-effect…
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Hospital-Level Care at Home for Adults Living in Rural Settings: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of home hospital care in rural settings, cost and readmission were unchanged while patient activity and experience improved. Late transfer home likely attenuated the intervention’s effect.
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Magnetic seed versus guidewire-based breast cancer localization with magnetic lymph node detection: cost-minimization analysis
CONCLUSION: In this predefined health economic analysis of an RCT, the use of magnetic seeds resulted in incremental cost containment, despite the increased cost of the device. Contributing factors included shorter localization time, shorter operating time, and process streamlining.
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Impacts of Experimental Knee Pain on Gait Biomechanics and Pain Sensitivity: A Randomised Crossover Trial of Young and Pain-Free Volunteers
CONCLUSION: Changes in PPTs and propulsion impulse were observed after the knee pain induction. Peak knee pain variability can be partly explained using a combination of biomechanics, pain sensitivity and cognitive factors. This forms the basis for a targeted clinical evaluation of patients.
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The effect of posture and breathing exercises applied with telerehabilitation on respiratory functions, exercise capacity, fatigue, and psychosocial factors in chronic obstructive pulmonary disease patients
CONCLUSION: It was concluded that exercise with telerehabilitation in COPD patients is effective on quality of life, exercise capacity, fatigue, psychosocial factors and can be used as a treatment approach.
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Effect of flywheel resistance training on sleep quality in older women: A randomized controlled trial
CONCLUSION: Eight weeks of intervention did not affect objective sleep measures but improved subjective sleep quality, particularly in the FRT group.