Clinical Trials
Category Added in a WPeMatico Campaign
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Concentration-Response Analysis of the Combination of Pyronaridine and Piperaquine on Corrected QT Interval From a Randomized, Double-Blind, Placebo-Controlled Study in Healthy Adults of African Sub-Saharan Origin
A novel oral combination of the long-acting antimalarials pyronaridine (PYR) and piperaquine (PQP) has potential for malaria chemoprevention. This single-center randomized, double-blind, placebo-controlled study assessed the effects of PYR and PQP alone and when co-administered on Fridericia-corrected QT interval (QTcF). Between February 14, 2022, and May 31, 2022, thirty-seven healthy black adults of African sub-Saharan…
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Amino acid composition of plant protein-enriched wheat biscuits differentially affects postprandial amino acid responses of overweight/obese compared to normalweight subjects
CONCLUSION: Ingestion of plant protein-enriched wheat biscuits by OW subjects resulted in lower postprandial responses of alanine, glutamine and threonine compared to NW. AAs composition of BCAAs-enriched biscuit resulted also in lower responses of asparagine and serine while that of the L-arg-enriched biscuit, in lower glycine but higher taurine responses in OW compared to NW…
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Effects of lumbar stabilization exercises on serum biomarker levels and clinical outcomes in lumbar disc herniation: a subgroup analysis of a randomized controlled trial
CONCLUSION: Our results demonstrate that no effect of lumbar stabilization exercise is seen on circulating levels of TNF-α, IL-1β, IL-6, IL-4, BE, AEA, and 2-AG. Further exercise trials are needed to investigate what type, duration, and intensity of exercise is relevant for biomarkers that may play a role in the immune process.
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Women with endometriosis: Experiences with pain management and views on optimal healthcare through the concept of health literacy
CONCLUSION: A need emerges for improved dissemination of information, enhanced monitoring, and health expertise at an organisational level within the healthcare system. Thus, future health care services should aim to provide seamless, multidisciplinary treatment to improve patient satisfaction.
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Factors Associated With Self-Report Symptom Screening Adherence in Pediatric Cancer Patients
CONCLUSION: Adherence to three-times weekly SSPedi varied by age, race, ethnicity, cancer diagnosis, and family income. This information may facilitate interventions to support routine symptom screening in clinical practice.
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The Evaluation of Memantine Effect on Tinnitus Severity
CONCLUSION: On the basis of these findings, it is suggested that memantine may have remarkable effect in reducing tinnitus and its discomfort.
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Intensive Blood Pressure Control in Patients With Diabetes and Previous Stroke: A Post-Hoc Analysis of ACCORD-BP Trial
Intensive systolic blood pressure (SBP) control reduces cardiovascular outcomes in hypertensive patients, but its effects in those with diabetes and prior stroke need further evidence. Among 4733 patients with elevated SBP enrolled in the ACCORD-BP (Action to Control Cardiovascular Risk in Diabetes-Blood Pressure) trial, this post-hoc analysis focused on 307 patients with type 2 diabetes…
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Impact of root canal shaping using TruNatomy on postoperative pain and operative torque generation: a randomized clinical trial
CONCLUSION: TN and RC rotary instruments resulted in similar and acceptable levels of post-operative pain in cases of asymptomatic necrotic teeth. However, TN rotary system combined torque and instrumentation time values suggest an overall higher cutting efficiency and potentially a better safety profile as compared to RC rotary system.
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Clinical Efficacy of a Salicylic Acid-Containing Gel on Acne Management and Skin Barrier Function: A 21-Day Prospective Study
CONCLUSION: The salicylic acid-containing gel effectively reduces acne lesions, regulates sebum production, enhances skin hydration, and strengthens the skin barrier, making it a suitable option for acne-prone and sensitive skin. These findings suggest that the gel provides a well-balanced approach to acne treatment by addressing both clinical efficacy and user comfort.
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Innovative nitric oxide delivery technology for postoperative pulmonary hypertension in congenital heart disease patients: a clinical trial
CONCLUSION: The ENG provided stable NO delivery, ensuring safety and efficacy in postoperative adult CHD-PAH patients. It was associated with improvements of hemodynamics and gas exchange without systemic side effects, offering a compact, efficient, and cost-effective alternative to traditional iNO delivery systems. This research was registered with the Clinical Trial Registry at http://www.chictr.org.cn , under…