Clinical Trials
Category Added in a WPeMatico Campaign
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The efficacy and safety of hydroxychloroquine in patients with chronic inflammatory cardiomyopathy: a multicenter randomized study (HYPIC trial)
CONCLUSIONS: Twelve months of HCQ combined with PDN therapy significantly improved the prognosis and heart function, inhibited inflammation, and had acceptable safety in patients with infl-CMP after FM.
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Cost-effectiveness of rapid, ICU-based, syndromic PCR in hospital-acquired pneumonia: analysis of the INHALE WP3 multi-centre RCT
CONCLUSIONS: We found lower average ICU costs with the Pneumonia Panel. The pneumonia panel was cost-effective in terms of antibiotic stewardship, but not clinical cure.
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Callback time preference for prescreening visits among Black residents in the Boston area: findings from two randomized controlled trials
CONCLUSION: Contacting participants during their preferred callback time was associated with reaching them and completing a prescreening interview. These data highlight the importance of study teams’ flexibility in outreach time to enhance the recruitment of Black adults into cardiovascular clinical trials.
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Sleep quality patterns in patients with heart failure: a person-centred latent class analysis from a secondary analysis of the MOTIVATE-HF trial
CONCLUSIONS: Patients with HF exhibit heterogeneous sleep quality patterns with specific clinical and psychological profiles. These findings highlight the need for personalised interventions, systematic sleep assessments and the integration of cardiac rehabilitation strategies into standard HF care.
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Psychoeducation Group for Depression (PEG-D): Study protocol for a prospective, randomized, single-blind, crossover trial
BACKGROUND: Considered a leading contributor to the global health burden, depression is characterized by its multifaceted nature. Recognizing the limitations of pharmacological treatments, non-pharmacological alternatives have been suggested to enhance full remission and increase quality of life.
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A Digital Therapeutic Intervention for Inpatients With Elevated Suicide Risk: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, the digital therapeutic intervention did not change the time to first actual suicide attempt but helped to sustain reductions in suicidal ideation among inpatients with elevated suicide risk. However, among patients with prior suicide attempts, the digital therapeutic intervention helped reduce recurrent suicide attempts and increased the…
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Osa in women: When does cpap increase blood pressure?
CONCLUSION: Greater age, the presence of depression and higher baseline AHI and SBP were independently associated with a clinical significant increase in BP after CPAP, regardless of their adherence. These changes in BP appeared mainly during the first month of treatment.
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How Does Mobile Technology Shape the Perceptions of People with Type 2 Diabetes?
We conducted a randomised clinical trial involving 43 patients diagnosed with type 2 diabetes. For four weeks, participants used the forDiabetes: diabetes self-management mobile app. Using a questionnaire to assess perceptions of the disease, we observed how the use of mobile technology affects perceptions of the disease. We found that participants in the mobile app…
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Efficacy of Non-Ablative Fractional Laser Combined With Tranexamic Acid in Melasma Treatment: A Randomized Split-Face Trial
CONCLUSIONS: The combination of NAFL and topical TXA provides significant short-term clinical benefits in treating melasma, likely by enhancing TXA penetration into target tissues and improving pigmentary clearance. However, its efficacy diminishes over time due to the inevitable recurrence of melasma, necessitating further investigation into long-term maintenance strategies.
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Barriers to Digital Mental Health Services Among College Students
This qualitative study explores barriers to digital mental health Intervention (DMHI) use among college students. Data are from a randomized trial of eBridge, which used motivational interviewing to connect students with mental health concerns to professional care. Thematic analysis of participant feedback on their experience with the DMHI platform revealed nine key obstacles to adoption:…