Clinical Trials
Category Added in a WPeMatico Campaign
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Effect of conditioned stimuli-triggered memory retrieval-extinction in patients with methamphetamine use disorder
Methamphetamine (METH) is a widely abused stimulant that affects the central nervous system. The persistent maladaptive conditioned stimuli (CS, drug cues)-drug associative memories represent a primary factor precipitating relapse. Interfering with the reconsolidation of these memories may help disrupt and modify these maladaptive CS-drug associations, potentially reducing their influence on drug-seeking behavior. The present study…
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Implementing exercise and self-management for women with breast cancer during treatment: results of the NEXT-BRCA randomized controlled trial
The purpose of this study was to determine the feasibility (recruitment, retention, and adherence rates) and effectiveness of institution-based exercise and self-management (SM) on physical activity (PA) level, exercise knowledge and intention, health status, functional capacity, patient engagement, and lower extremity strength for individuals with breast cancer receiving treatment. We conducted a hybrid implementation-effectiveness trial…
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Combination of fentanyl and metoprolol in anesthesia in elderly patients: Effects on postoperative pain management and cardiovascular stability
Elderly patients undergoing surgery may benefit from improved postoperative pain management and cardiovascular stability through the combination of metoprolol, a selective β1-adrenergic blocker and fentanyl, an opioid analgesic. This double-blind randomized controlled trial evaluated the efficacy of this combination in 200 elderly patients scheduled for elective surgeries. Participants were divided into two groups: The experimental…
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Efficacy of cyclosporine eye drops in managing post-cataract surgery dry eye symptoms: A randomized controlled trial
Many patients develop dry eye symptoms or further exacerbation post-cataract surgery. The aim is to analyse the efficacy of cyclosporine A (CsA) eye drops on the dry eye symptoms post-cataract surgery (DEPC). 100 DEPC patients admitted to First Affiliated Hospital of Gannan Medical University from August 2022 to August 2024 were randomly divided into control…
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The application of stay sutures in thoracoscopic esophageal repair for Type C esophageal atresia
CONCLUSION: This innovative approach significantly shortens the operative time in the thoracoscopic treatment of Type C EA.
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Effects of liquid resuscitation guided by internal jugular vein variability during deep inhalation on preventing propofol-induced hypotension in elderly patients
CONCLUSIONS: A significant relationship was observed between IJVV levels during deep inhalation and the blood pressure decline following propofol induction. Administering IJVV-A guided fluid infusion can significantly reduce propofol-induced hypotension by keeping the IJVV-A less than 23.42% during deep inspiration.
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Whole body MRI by MY-RADS for imaging response assessment in multiple myeloma
Minimal residual disease (MRD) testing has underpinned the evaluation and expansion of therapeutic options for patients with multiple myeloma (MM). Imaging is essential for evaluating residual disease status, overcoming sampling errors inherent with other MRD modalities. The accuracy of whole-body MRI (WB-MRI) has led to its incorporation into MM diagnostic imaging guidelines. We report here…
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Prognostic and Prescriptive Predictors of Treatment Response to Adjunctive VNS Therapy in Major Depressive Disorder: A RECOVER Trial Report
Objective: Vagus nerve stimulation (VNS) therapy is a long-term intervention for treatment-resistant major depression (TRD) adjunctive to treatment as usual (TAU). To enhance clinical decision- making, we identified subgroups that respond especially well or poorly with active VNS vs no stimulation sham VNS (prognostic predictors) and subgroups that specifically benefit from active VNS vs sham…
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Homelessness, Patient Navigation, and Lung Cancer Screening in a Health Center Setting: A Subgroup Analysis of a Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this subgroup analysis of a randomized clinical trial, patient navigation increased LCS participation among both patients currently and formerly experiencing homelessness; however, the effect size was smaller for those currently experiencing homelessness. Further improving cancer outcomes among HCH patients may require refinement of the patient navigation intervention, coupled with policy efforts…
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One-Year Trajectory of Pain, Function, and Health-Related Quality of Life in Patients With Plantar Fasciopathy
CONCLUSIONS: Different recovery trajectories are important to consider when determining timepoints for follow-up in scientific studies as well as to individualize the clinical follow-up.