Clinical Trials
Category Added in a WPeMatico Campaign
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Impact of an Evidence-Based Large Language Model (LLM) Diagnostic Decision Support System: A Randomised Controlled Trial
Generative artificial intelligence (AI) influences clinical decision-making in healthcare by analyzing medical data and proposing personalized treatment options based on patient records. However, generative AI limited due to its inability to provide accurate evidence. Therefore, this study aims that the influence of AI-generated diagnostic suggestions on emergency healthcare providers’ diagnostic patterns and decision-making, and evaluates…
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Petal-x Visualization for Lifestyle Change in Patients at Risk of Cardiovascular Diseases: An Evaluation
Cardiovascular diseases (CVDs) are the leading global cause of death and addressing unhealthy lifestyles is essential for reducing CVD risk. Visual explanations, such as the Petal-X dashboard, can support personalized care by improving patients’ understanding of health risks and motivating lifestyle changes. This study evaluated whether the Petal-X dashboard, utilizing the SCORE2 model for 10-year…
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The effect of hope-based counseling on perceived stress and the quality of life in pregnant women experiencing nausea and vomiting: a randomized control trial
CONCLUSION: Counseling based on hope therapy was effective in reducing perceived stress and improving the quality of life for pregnant women experiencing nausea and vomiting. Implementing this approach could be a valuable strategy for health policymakers to enhance the quality of life for pregnant women, particularly those dealing with pregnancy-related nausea and vomiting.
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Effects of combined supervised and telerehabilitation exercise programs on pain and disability in dentists with chronic neck pain: a randomized controlled trial
CONCLUSIONS: The results showed that combined exercises applied under supervision were more effective than telerehabilitation or home exercises in dentists with CNP, and telerehabilitation was more effective than home program. Although the telerehabilitation method is not as effective as supervised exercise training, it can be an alternative method to reduce pain and disability for dentists…
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Open-Label Study: Over-the-Counter Oat Flour/Oat Oil/ Oat Extract-containing Lotion With Avenanthramides for Sensitive Skin and Psoriasis
CONCLUSIONS: This study provides evidence supporting the efficacy and tolerability of a topical, over-the-counter lotion containing oat flour, oat oil and oat extract with avenanthramides as the sole intervention for managing the symptoms of sensitive skin and mild to moderate psoriasis.
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Safety and Tolerability of Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% Gel for Truncal Acne
CONCLUSIONS: In this pooled analysis, fixed-dose CAB gel was well tolerated over 12 weeks in participants treating their truncal acne. The lack of safety signals combined with the favorable safety/tolerability profile of CAB shows that it is a safe treatment option for truncal and facial acne.
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Deucravacitinib With Add-On Calcipotriene/Betamethasone Dipropionate for Treating Moderate to Severe Plaque Psoriasis
BACKGROUND: To assess the effectiveness, safety, and quality of life in patients who received topical calcipotriene/betamethasone dipropionate (C/BD) foam added to oral deucravacitinib for treating moderate to severe, chronic plaque psoriasis.
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Designing and evaluation of the effect of community-based intervention on breast self-examination among reproductive-aged women in Ethiopia: A Cluster Randomized Controlled Trial
CONCLUSIONS: The study found that there is a strong interplay between the likelihood of performing breast self-examination and perceived susceptibility, perceived severity, knowledge, and health motivations. Field specialists should figure out the problem related to perception and awareness through intensive health promotion interventions.
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Multicenter Prospective Randomized, Double-Blind, Placebo-Controlled Pharmacodynamic Study of The Additional Antihypertensive Effect of the Drug in Patients With Uncontrolled Arterial Hypertension Against the Background of Taking Renin-Angiotensin-Aldosterone System Blockers
Aim To evaluate the efficacy and safety of a single sublingual dose of captopril in patients with poor control of arterial hypertension (AH) despite continuous use of long-acting angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs). The safety of a single additional dose of a short-acting ACE inhibitor to relieve elevations of blood…
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Carfilzomib-lenalidomide-dexamethasone versus lenalidomide-dexamethasone in patients with newly diagnosed myeloma ineligible for autologous stem-cell transplantation (EMN20): a randomised, open-label, multicentre, phase 3 trial
BACKGROUND: Before the introduction of daratumumab-lenalidomide-dexamethasone as a first-line treatment for patients with newly diagnosed transplant-ineligible multiple myeloma, lenalidomide-dexamethasone was a standard of care. We aimed to explore whether addition of the second-generation proteasome inhibitor carfilzomib to lenalidomide-dexamethasone improved the rates of measurable residual disease (MRD) negativity and progression-free survival.