The randomized, phase 2 GRIFFIN study (NCT02874742) evaluated daratumumab plus lenalidomide/bortezomib/dexamethasone (D-RVd) in transplant-eligible newly diagnosed multiple myeloma (NDMM). We present final post hoc analyses (median follow-up, 49.6 months) of clinically relevant subgroups, including patients with high-risk cytogenetic abnormalities (HRCAs) per revised definition (del[17p], t[4;14], t[14;16], t[14;20], and/or gain/amp[1q21]). Patients received 4 induction cycles (D-RVd/RVd),… →
Cardiotoxicity is a side effect of chemotherapy in human epidermal growth factor receptor 2 (HER2) positive breast cancer patients receiving both anthracyclines and trastuzumab. We looked for a possible protective effect of rosuvastatin against chemotherapy-induced cardiotoxicity. Methods: 50 newly diagnosed HER2 positive breast cancer patients were randomly allocated into two groups: 25patients in each. Group… →
CONCLUSIONS: Paclitaxel can cause neuropathy, lasting for a long time. Our study showed duloxetine is potentially an effective medication that can prevent subjective and objective neuropathy. →
Frontloading home care visits has been found to be effective in the nursing profession but has not been investigated in physical therapy (PT) practice. This study aimed to examine the impact of frontloading home PT visits on function in persons with heart failure (HF). This was a prospective multi-center randomized controlled trial with blinded raters.… →
CONCLUSION: There was no RBC alloimmunization in participants with cancers. Routine RBC allo-antibody screening in all patients with cancer in SSA requires further research. →
CONCLUSION: The safety and efficacy of remimazolam besylate are not inferior to those of etomidate combined with propofol, rendering it a safe option for sedation during gastrointestinal endoscopy in ASA I-II elderly patients, but care should be taken to monitor the occurrence of hiccups. →
The research on vision-language models (VLMs) has gained significant momentum, driven by their potential to revolutionize various applications, including visual assistance for visually impaired individuals. However, current evaluations of these models often need to pay more attention to the complexities introduced by multi-object scenarios and diverse cultural contexts. Two notable studies shed light on these… →
Graph comprehension and complex reasoning in artificial intelligence involve developing and evaluating the abilities of Large Language Models (LLMs) to understand and reason about graph-structured data. This field is critical for various applications, including social network analysis, drug discovery, recommendation systems, and spatiotemporal predictions. The goal is to advance the capabilities of AI to handle… →
Accurately modeling magnetic hysteresis is a significant challenge in the field of AI, especially for optimizing the performance of magnetic devices such as electric machines and actuators. Traditional methods often struggle to generalize to novel magnetic fields, limiting their effectiveness in real-world applications. Addressing this challenge is crucial for developing efficient and generalizable models that… →
Large Language Models (LLMs) with parametric memory of rules and knowledge have shown limitations in implicit reasoning. Research has shown that these models, even more complex ones like GPT-4, have trouble applying and integrating internalized facts reliably. For instance, even when they are aware of the entities in question, they frequently make inaccurate comparisons of… →