CONCLUSIONS: The occurrence of OH requires close monitoring, with caution for potential cognitive adverse effects during ongoing intensive BP-lowering treatment. Validation of current findings in studies with justified methodological designs is warranted. →

BACKGROUND: Peru has one of the highest burdens of asthma in the world, as well as large gaps in access to evidence-based treatments. Studies often overlook the ways in which the research context and data collection activities interact and influence the experience of a research participant, their perception of an intervention, and, by extension, study… →

BACKGROUND Patellofemoral pain syndrome (PFPS) limits physical activity and quality of life, especially during weight-bearing tasks. Although high-load resistance exercises are recommended for rehabilitation, they may worsen symptoms in pain-sensitive individuals. Low-intensity blood flow restriction (BFR) training has emerged as a potential alternative. However, its effects on functional performance and mechanical properties remain unclear. MATERIAL… →

The aim of this randomized controlled clinical study is to compare the effect of intracanal cryotherapy and intraoral Low-Level LASER Therapy (LLLT) applications on postoperative pain and quality of life in patients following endodontic treatment for symptomatic apical periodontitis. After ethical clearance and registering the trial at clinical trial registry of India, a randomized, parallel-controlled… →

CONCLUSIONS: PCI was effective across all ages in reducing angina frequency. Notably, there was limited improvement in treadmill exercise time in the elderly, challenging its role as a primary endpoint in many antianginal trials. These data should inform cardiovascular clinical trial design to ensure applicability across all ages. (Objective Randomized Blinded Investigation With Optimal Medical… →

CONCLUSION: Parents recognised the pressures on services to offer timely support; however, their well-being could be substantially improved by more clarity around wait times, as well as more effective signposting and support from services concerning the assessment process. This may help alleviate some of the stressors associated with their child’s assessment journey, such as feeling… →

INTRODUCTION: Depression is one of the most serious mental health disorders worldwide. Forest therapy has been shown to be an effective non-pharmacological intervention. This study examined the development and implementation of personalized forest therapy programs for patients with depression, particularly their effects on stress levels and obsessive-compulsive symptoms. →

CONCLUSIONS: DIT combined with antidepressant medication demonstrated superior efficacy compared to medication alone in alleviating insomnia, depressive symptoms, and anxiety, as well as in improving sleep quality among college students with depressive disorders. These results support the integration of DIT into standard clinical care to address co-occurring depression and insomnia in this vulnerable population. However,… →

CONCLUSIONS: The ketogenic diet was associated with the most pronounced long-term metabolic improvements, whereas 16:8 time-restricted eating yielded faster early responses and the most stable enhancement in Orexin-A levels. These findings indicate distinct metabolic and neuroendocrine adaptation profiles across dietary strategies. Given the small sample size, results should be interpreted cautiously, and larger trials are… →