CONCLUSION: Rhythmic music game intervention effectively enhances inhibitory control, cognitive flexibility, and sensorimotor coordination in children with ADHD. Given its engaging nature and accessibility, it holds promise as a valuable component within multidisciplinary intervention strategies, offering a practical approach to supporting the healthy development of children with ADHD. →

Clarithromycin resistance is a major determinant of treatment failure, and the benefits of susceptibility-guided therapy in high-resistance settings remains incompletely understood. To evaluate the clinical effectiveness of the susceptibility-guided compared with the empirical therapy in treatment-naïve H. pylori infection in a high resistance setting. In this single-centre, randomised, superiority trial, 500 treatment-naïve adults were allocated… →

AimThe phase 4 RESOLUTION trial showed that, in comparison with placebo, adding eptinezumab-an anti-calcitonin gene-related peptide monoclonal antibody-to a brief educational intervention (BEI) reduced the monthly frequency of migraine, headache, and acute medication use in participants with chronic migraine (CM) and medication-overuse headache (MOH). Herein, we report data from multiple patient-reported outcomes (PROs) evaluating treatment… →

CONCLUSION: While both TMJ arthrocentesis alone and arthrocentesis supplemented with LLLT significantly improved maximum mouth opening and reduced pain, LLLT did not provide a significant incremental benefit over arthrocentesis with hyaluronic acid. These findings suggest that clinical improvements are primarily driven by the main intervention and may reflect a possible therapeutic ceiling effect, beyond which… →

CONCLUSION: The targeted mobilization program applied after cesarean surgery enhanced overall postoperative recovery by accelerating bowel function, reducing abdominal distension and pain, and improving breastfeeding outcomes. These findings support the integration of structured mobilization strategies into routine post-cesarean care. →

CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of MDD, a single dose of psilocybin was associated with rapid antidepressant effects, observed by day 2 and persisting for more than 3 months on secondary outcomes; psilocybin was generally well tolerated, but some individuals required additional support after dosing due to anxiety. These results suggest that… →

Background: Negative symptoms remain among the most debilitating and treatment-resistant features of schizophrenia. Repetitive transcranial magnetic stimulation, particularly intermittent theta burst stimulation (iTBS), is emerging as a promising intervention targeting these domains. →

Objective: This post hoc analysis assessed the benefit-risk of aripiprazole once-monthly 400 mg (AOM 400) as acute and long-term maintenance treatment for patients diagnosed with schizophrenia, based on number needed to treat (NNT), number needed to harm (NNH), and likelihood to be helped or harmed (LHH). →

CONCLUSIONS: The program has the potential to improve transitional care in older adults with diabetes, warranting further promotion. →