This single-blind, randomized clinical trial evaluated the impact of a strict oral hygiene (OH) phase on self-reported halitosis and quality of life (QoL) in patients with periodontitis. This study reports a secondary analysis of a single-blind randomized controlled trial (parallel, 1:1), registered at RBR-5jmx32v. The study included 24 individuals diagnosed with periodontitis who were randomly… →

CONCLUSION: In non-exclusively breastfed infants at high-risk for allergy, mixed-feeding with a specific whey-based pHF during the first 6 months of life may reduce the risk of atopic dermatitis and food allergy from birth up to the age of 5 years. However, further A.R.T. follow-ups and other longitudinal studies with larger sample size are needed… →

CONCLUSIONS: In recent-onset psychosis patients, MCT demonstrated the expected benefits in conviction, as ‘sowing seeds of doubt’ is the core MCT mechanism of change. Despite functioning differently, both interventions improved patients’ self-esteem. No superiority of MCT was discovered in self-esteem or depression in the short-term follow-up studied. →

CONCLUSIONS: Proportion of participants who completed health coaching was high, though proportion of approached participants who consented was lower than expected. Our acceptability and efficacy targets were met. Further phase III testing is planned. →

CONCLUSION: GutBio Plus is a safe and effective treatment for chronic constipation, offering significant symptom relief and an improved quality of life. The sustained benefits highlight its potential as a reliable alternative to conventional laxatives. →

CONCLUSION: Overall, music-based occupational therapy activities demonstrated positive effects on attention levels, executive functions, and caregiver burden in children with ADHD. Future studies are encouraged to incorporate a broader range of musical instruments into occupational therapy intervention plans, aligned with specific therapeutic goals. It is considered important for therapists to develop strategies that tailor the… →

CONCLUSIONS: No definitive conclusions can be drawn from this study. Preliminary results suggest that Intensive Community Care Services may support a faster return to education, employment or training than treatment as usual. Intensive Community Care Services may be cost-effective compared to treatment as usual. Additional mental health professionals should be deployed to Intensive Community Care… →

CONCLUSION: Perioperative subanesthetic esketamine may provide modest improvement in early postoperative pain sensitivity, and may serve as a useful adjunct in multimodal postoperative analgesia for emergency laparoscopic salpingectomy. →

BACKGROUND: Emerging observational studies suggest that air pollution can influence the gut microbiome. However, this association is often highly confounded by factors, such as diet and poverty. The gut virome may influence respiratory health independent of the gut microbiome. We recently demonstrated in a randomized waitlist-controlled trial (ClinicalTrials.gov NCT03351504) that a clean lighting intervention reduced… →

INTRODUCTION: Polycystic ovary syndrome (PCOS) affects 5-20% of adolescent females worldwide, yet scalable non-pharmacological interventions remain scarce. Tai Chi, a traditional Chinese mind-body exercise, may address the complex metabolic, reproductive, and psychosocial dimensions of PCOS, but robust randomized controlled trial evidence is lacking. →