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Heart rate variability biofeedback in adults with chronic spinal cord injury: a randomised feasibility study
CONCLUSIONS: With the proposed modifications implemented, the RCT is deemed feasible for investigating the effectiveness of a 10-week HRV-F intervention for adults with chronic SCI. →
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Redox-sensitive miRNAs and Humanin could mediate effects of exercise and astaxanthin on oxidative stress and inflammation in type 2 diabetes
Type 2 diabetes mellitus (T2DM) is driven by oxidative stress (OS) and inflammation (IF), accelerating disease progression. This study examined whether combined aerobic and resistance training (CT) and astaxanthin (AST) supplementation synergistically improve oxidant and inflammatory status as well as metabolic indices in T2DM, focusing on the mediatory role of Humanin (HN) and microRNAs (miRNA-122,… →
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Enhanced nursing and ganciclovir improve outcomes in paediatric Epstein-Barr Virus infectious mononucleosis: A Randomised Control Trial
CONCLUSIONS: Ganciclovir and good nursing improved paediatric Epstein-Barr virus infectious mononucleosis treatment. →
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Dopamine versus norepinephrine in fluid-refractory septic shock among preterm neonates: a double-blind randomized controlled trial
The present study aims to compare the efficacy and safety of norepinephrine (NE) versus dopamine in achieving early (within 45 min of initiation) reversal of fluid-refractory septic shock in preterm neonates. A double-blind randomized controlled trial was conducted in a Level-III tertiary care hospital in Northern India. Fifty neonates born at a gestational age of… →
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The Leadership Test No One Wants: Delivering Bad News Well
Sergio Ingravalle/Ikon Images Every leader eventually faces the moment they dread most: standing before their people to deliver bad news. It’s the test no one asks for, yet it arrives for everyone who leads. When delivered poorly, bad news can drain trust and morale. It can sap the energy of the very people you need… →
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Efficacy and Safety of Methotrexate Administered by Oral and Subcutaneous Routes in Patients with Severe Psoriasis
CONCLUSION: The SC route of MTX administration is safer and more effective than the oral route in patients with severe psoriasis. →
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Pilot Study of Early Adoption of Automated Insulin Delivery in Underresourced Youth
CONCLUSION: Early initiation of AID is feasible and acceptable in youth with recently diagnosed T1D from underresourced populations who historically experience lower technology adoption and less optimal glycemic outcomes. Diabetes clinicians should consider providing tailored support and dedicated resources to families early in diagnosis with T1D to promote AID initiation and continued use. →
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VC 01: Inside the New Exit Economy: IPOs, Secondaries & AI with Meritech’s Alex Clayton
Listen on YouTube Listen on Apple Listen on Spotify Brought to you by: AngelList How did we build the GTMfund back office? Easy! We leveraged AngelList’s Rolling Fund product for Fund I, which was the perfect vehicle to scale up GTMfund in its first iteration. This structure allowed us to build our network, and add… →
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2′-Fucosyllactose supplementation results in a transient improvement in gut microbial resilience after vancomycin use in adults with overweight or obesity: a randomized, double-blind, placebo-controlled intervention
Antibiotic-induced perturbations of the gut microbiome can be long-lasting and potentially affect host metabolic health. Strategies supporting microbial resilience are needed to mitigate the negative impact of antibiotics. We investigated the potential of 2′-fucosyllactose (2′-FL) supplementation after vancomycin use in a double-blind placebo-controlled randomized intervention among adults with overweight/obesity. Participants received oral vancomycin for seven… →
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Effect of ketogenic diet plus dulaglutide on glucose and lipid metabolism in diabetes mellitus
Diabetes mellitus is a chronic disease with a high incidence worldwide and exclusive drug treatment has a limited effect. To investigate the effects of a ketogenic diet combined with dulaglutide on glucose and lipid metabolism in diabetic patients, a total of 104 patients with type 2 diabetes mellitus were randomly divided into a study group… →
