CONCLUSION: Benfotiamine reverses the changes of metabolites/lipids reflecting AD progression. Our ongoing NIH funded multicenter trial includes blood biomarkers of thiamine, amyloid, tau, inflammation, neurodegeneration, AGE, and extensive cognitive testing. A larger sample size is necessary to test whether metabolic biomarkers are useful for disease diagnosis, prognosis, and monitoring therapeutic efficacy. This research was partially… →
CONCLUSION: AXS-05 demonstrated a substantial, rapid reduction in ADA vs controls after 5 weeks of treatment, increased time-to-relapse vs placebo, and was well-tolerated, supporting its development as a promising treatment option for ADA. →
CONCLUSION: Preliminary findings from LatAm-FINGERS highlight the feasibility of conducting intervention trials within diverse populations. These findings underscore the importance of creating recruitment strategies that effectively engage underrepresented groups. This contributes significantly to global Alzheimer’s disease research efforts. The trial’s experience offers a valuable model for inclusive enrollment practices in Alzheimer’s disease and related dementia… →
CONCLUSION: Depending on correlations between prognostic scores and actual trial outcomes, a potential overall sample size reduction of 5-10% could be achieved using DT methodology (PROCOVA^(TM)) while maintaining statistical power, based on Δ CDR-SB and Δ ADAS-Cog 14 in the AWARE study. Sample size savings could enable shortening of the recruitment period and reduce the… →
CONCLUSION: A single bout of tVNS does not appear effective for improving cognition in individuals with MCI. →
CONCLUSION: Acute exercise decreases brain glucose metabolism in both cognitively healthy and impaired older adults. This effect tracks with the systemic lactate response. This supports the hypothesis that increased lactate may spare glucose and be a key brain fuel during exercise. Additional work to directly measure brain lactate metabolism following exercise and understand the role… →
Proteins, essential molecular machines evolved over billions of years, perform critical life-sustaining functions encoded in their sequences and revealed through their 3D structures. Decoding their functional mechanisms remains a core challenge in biology despite advances in experimental and computational tools. While AlphaFold and similar models have revolutionized structure prediction, the gap between structural knowledge and… →
Mathematical reasoning stands at the backbone of artificial intelligence and is highly important in arithmetic, geometric, and competition-level problems. Recently, LLMs have emerged as very useful tools for reasoning, showing the ability to produce detailed step-by-step reasoning and present coherent explanations about complex tasks. However, due to such success, it’s becoming harder and harder to… →
CONCLUSION: The preliminary findings indicate the intervention can lead to a sustained increase in knowledge and a shift in negative attitudes among CHWs over time. Further analysis are being carried out, including a qualitative assessment of the intervention, which will help improve the intervention to be applied in a randomized- controlled trial in the future. →
CONCLUSION: These promising results highlight the potential of biophoton therapy as a novel and safe intervention for Alzheimer’s disease. Further investigations are warranted to elucidate the underlying mechanisms. This clinical study represents a significant step forward in treating Alzheimer’s disease. →