Language models (LMs) have significantly progressed through increased computational power during training, primarily through large-scale self-supervised pretraining. While this approach has yielded powerful models, a new paradigm called test-time scaling has emerged, focusing on improving performance by increasing computation at inference time. OpenAI’s o1 model has validated this approach, showing enhanced reasoning capabilities through test-time… →
CONCLUSION: Intranasal insulin notably reduced the incidence and severity of POD in older patients undergoing joint replacement, which may be related to the elevation in osteocalcin and BDNF levels. →
CONCLUSIONS: COVID-19 is associated with relative AT3 deficiency (22% of this cohort). No bleeding complications or drug-related adverse events with exogenous AT3 were observed. There were no significant differences in length of stay or mortality. Further studies should evaluate higher doses of exogenous AT3 and focus on higher-risk groups. →
2025 is shaping up to be an exciting year for AI enthusiasts, thanks to the announcements of DeepSeek R1 and Qwen 2.5 Max! the latest breakthrough in AI technology from Alibaba Cloud. This is a significant step forward in the domain of large language models (LLMs). This update substantially improves efficiency, reasoning, and multimodal understanding,… →
BACKGROUND: Unhealthy alcohol use, a spectrum of use inclusive of risky consumption and alcohol use disorder (AUD), is a leading cause of preventable death in the United States. Most people with unhealthy alcohol use do not receive evidence-based treatment. This four-arm factorial design randomized trial will assess whether population health management (PHM) and clinical care… →
Anemia in pediatrics is often associated with chronic conditions such as chronic kidney disease (CKD). It can worsen the disease prognosis and affect quality of life. Injectable dosage forms are predominantly used in its treatment with various side effects. This randomized and parallel clinical trial aimed to compare the effectiveness of oral lactoferrin with intravenous… →
BACKGROUND: Adding anti-CD38 monoclonal antibodies to standard therapies can improve outcomes in patients with multiple myeloma. Long-term treatment with corticosteroids increases the risk of infection. We aimed to evaluate the safety and activity of isatuximab, weekly bortezomib, lenalidomide, and limited dexamethasone in patients with newly diagnosed multiple myeloma ineligible for autologous haematopoietic stem-cell transplantation (HSCT). →
Beta-blockers and nondihydropyridine calcium-channel blockers have been standard-of-care (SOC) medications for patients with symptomatic obstructive hypertrophic cardiomyopathy (oHCM), even though these agents do not directly affect the underlying pathophysiology of the disease. Cardiac myosin inhibitors act by decreasing the number of myosin heads binding to actin, reducing the pathologic hypercontractility of HCM, and have been… →
Ad hoc networks are decentralized, self-configuring networks where nodes communicate without fixed infrastructure. They are commonly used in military, disaster recovery, and IoT applications. Each node acts as both a host and a router, dynamically forwarding data. Flooding attacks in ad hoc networks occur when a malicious node excessively transmits fake route requests or data… →