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Insights on the Choice and Preparation of the Donor Nerve in Corneal Neurotization for Neurotrophic Keratopathy: A Narrative Review

Pietro Luciano Serra April 27, 2024 J Clin Med. 2024 Apr 14;13(8):2268. doi: 10.3390/jcm13082268. ABSTRACT The article introduces neurotrophic keratopathy (NK), a condition resulting from corneal denervation due to various causes of trigeminal nerve dysfunctions. Surgical techniques for corneal neurotization (CN) have evolved, aiming to restore corneal sensitivity. Initially proposed in 1972, modern approaches offer… →

Adverse effects, AI, Clinical outcomes, Clinical research, Clinical study, Clinical trials, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
The Natural History of Retinal Sensitivity Loss in Diabetic Macular Ischemia over One Year Evaluated by Microperimetry

Wei-Shan Tsai April 27, 2024 J Clin Med. 2024 Apr 11;13(8):2219. doi: 10.3390/jcm13082219. ABSTRACT Background/Objectives: This one-year prospective observational study, conducted at two centers, aimed to report the natural history of retinal sensitivity (RS) loss in diabetic macular ischemia (DMI). Methods: Patients with stable-treated proliferative diabetic retinopathy (PDR) were recruited if there was evidence of… →

Adverse effects, AI, Clinical outcomes, Clinical research, Clinical study, Clinical trials, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Smoking, Lung Cancer Stage, and Prognostic Factors-Findings from the National Lung Screening Trial

Junjia Zhu April 27, 2024 Int J Environ Res Public Health. 2024 Mar 26;21(4):400. doi: 10.3390/ijerph21040400. ABSTRACT BACKGROUND: Low-dose computed tomography (LDCT) increases the early detection of lung cancer. Identifying modifiable behaviors that may affect tumor progression in LDCT-detected patients increases the likelihood of long-term survival and a good quality of life. METHODS: We examined… →

Adverse effects, AI, Clinical outcomes, Clinical research, Clinical study, Clinical trials, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
The Impact of Laparoscopic Myomectomy on Pregnancy Outcomes: A Systematic Review

Ligia Balulescu April 27, 2024 J Pers Med. 2024 Mar 25;14(4):340. doi: 10.3390/jpm14040340. ABSTRACT STUDY OBJECTIVE: The objective of this systematic review is to investigate the impact of laparoscopic myomectomy techniques on pregnancy outcomes, with a specific focus on the correlation between the type of suture used during the procedure and the incidence of uterine… →

Adverse effects, AI, Clinical outcomes, Clinical research, Clinical study, Clinical trials, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Targeted Nanoparticle-Based Diagnostic and Treatment Options for Pancreatic Cancer

Xin Gu April 27, 2024 Cancers (Basel). 2024 Apr 20;16(8):1589. doi: 10.3390/cancers16081589. ABSTRACT Pancreatic ductal adenocarcinoma (PDAC), one of the deadliest cancers, presents significant challenges in diagnosis and treatment due to its aggressive, metastatic nature and lack of early detection methods. A key obstacle in PDAC treatment is the highly complex tumor environment characterized by… →

Adverse effects, AI, Clinical outcomes, Clinical research, Clinical study, Clinical trials, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Latest Insights and Therapeutic Advances in Myelodysplastic Neoplasms

Pasquale Niscola April 27, 2024 Cancers (Basel). 2024 Apr 19;16(8):1563. doi: 10.3390/cancers16081563. ABSTRACT Myelodysplastic syndromes/neoplasms (MDSs) encompass a range of hematopoietic malignancies, commonly affecting elderly individuals. Molecular alterations in the hematopoietic stem cell compartment drive disease pathogenesis. Recent advancements in genomic profiling have provided valuable insights into the biological underpinnings of MDSs and have expanded… →

Adverse effects, AI, Clinical outcomes, Clinical research, Clinical study, Clinical trials, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
Molecular Landscape and Therapeutic Strategies against Colorectal Cancer

Aakash Patel April 27, 2024 Cancers (Basel). 2024 Apr 18;16(8):1551. doi: 10.3390/cancers16081551. ABSTRACT Colorectal cancer (CRC) is the second leading cause of cancer deaths worldwide. Although the overall incidence of CRC is decreasing, the incidence of young-onset CRC, characterized by a diagnosis of CRC before age 50, is increasing. Outcomes for CRC patients are improving,… →

Adverse effects, AI, Clinical outcomes, Clinical research, Clinical study, Clinical trials, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
The Prognostic Value of the Systemic Immune-Inflammation Index (SII) and Red Cell Distribution Width (RDW) in Patients with Cervical Cancer Treated Using Radiotherapy

Emilia Staniewska April 27, 2024 Cancers (Basel). 2024 Apr 18;16(8):1542. doi: 10.3390/cancers16081542. ABSTRACT INTRODUCTION: There is growing interest in the prognostic value of routinely performed pre-treatment blood test indices, such as the RDW or SII, with the latter combining the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). These indices were shown to be prognostic for… →

Adverse effects, AI, Clinical outcomes, Clinical research, Clinical study, Clinical trials, Control arm, Data collection, Double-blind, Drug trial, Efficacy, Patient consent, Patient enrollment, Placebo, Randomization, Regulatory approval, Safety profile, Study design, Study protocol, Treatment group, Trial monitoring, Trial phase
FlashSpeech: A Novel Speech Generation System that Significantly Reduces Computational Costs while Maintaining High-Quality Speech Output

In recent years, speech synthesis has undergone a profound transformation thanks to the emergence of large-scale generative models. This evolution has led to significant strides in zero-shot speech synthesis systems, including text-to-speech (TTS), voice conversion (VC), and editing. These systems aim to generate speech by incorporating unseen speaker characteristics from a reference audio segment during… →
Mixture of Data Experts (MoDE) Transforms Vision-Language Models: Enhancing Accuracy and Efficiency through Specialized Data Experts in Noisy Environments

The interdisciplinary domain of vision-language representation seeks innovative methods to develop systems to understand the nuanced interactions between text and images. This area is pivotal as it enables machines to process and interpret the vast amount of digitally available visual and textual content. Despite significant advances, the challenge persists primarily due to the noisy data… →