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Effect of Tadalafil on cardiac function and left ventricular dimensions in Duchenne muscular dystrophy: safety and cardiac MRI substudy results from a randomized, placebo-controlled trial
CONCLUSIONS: No adverse effects of tadalafil on cardiovascular function were evident based on adverse events, echocardiograms, ECG, or vital sign measurements through 48 weeks in patients with DMD. The small mean increases in LVID and LV volume observed with tadalafil are consistent with PDE5 inhibitor pharmacology, but their clinical relevance in the context of LV… →
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A proof of concept study on digital interventions for reducing socio-evaluative stress and anxiety in youth
Youth often struggle with heightened sensitivity to social judgement, increasing their vulnerability to fear in social situations. This study investigates brief digital interventions aimed at regulating cognitive and affective disturbances related to social anxiety, specifically focusing on fear responses in a social-evaluative threat context. One-hundred-twenty healthy youth were randomly assigned to one of four conditions:… →
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Spectral shaping technology reduces the radiation dose of CT-guided lung tumor microwave ablation
Reducing the radiation dose and maintaining treatment efficacy during microwave ablation (MWA) of lung tumors is of great importance. The objective of this study is to evaluate the feasibility of using spectral shaping technology (^(100)Sn kV) to reduce radiation dose in CT-guided lung tumor MWA. Here, we conducted a prospective, randomized, double-blind and non-inferiority trial… →
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Fast Track Pathway to Accelerated Cholecystectomy Versus Standard of Care for Acute Cholecystitis (FAST) pilot trial
CONCLUSION: In our pilot trial, we found that accelerated cholecystectomy was achievable. These results show the feasibility of a trial comparing accelerated and standard care among patients requiring surgery for acute cholecystitis and support a definitive trial. →
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Google AI Introduce the Articulate Medical Intelligence Explorer (AMIE): A Large Language Model Optimized for Diagnostic Reasoni…
Google AI Introduce the Articulate Medical Intelligence Explorer (AMIE): A Large Language Model Optimized for Diagnostic Reasoning, and Evaluate its Ability to Generate a Differential Diagnosis Developing an accurate differential diagnosis (DDx) is a fundamental part of medical care, typically achieved through a step-by-step process that integrates patient history, physical exams, and diagnostic tests. With… →
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Step by Step Coding Guide to Build a Neural Collaborative Filtering (NCF) Recommendation System with PyTorch…
Step by Step Coding Guide to Build a Neural Collaborative Filtering (NCF) Recommendation System with PyTorch This tutorial will walk you through using PyTorch to implement a Neural Collaborative Filtering (NCF) recommendation system. NCF extends traditional matrix factorisation by using neural networks to model complex user-item interactions. Introduction Neural Collaborative Filtering (NCF) is a state-of-the-art… →
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Moonsight AI Released Kimi-VL: A Compact and Powerful Vision-Language Model Series Redefining Multimodal Reasoning, Long-Context…
Moonsight AI Released Kimi-VL: A Compact and Powerful Vision-Language Model Series Redefining Multimodal Reasoning, Long-Context Understanding, and High-Resolution Visual Processing Multimodal AI enables machines to process and reason across various input formats, such as images, text, videos, and complex documents. This domain has seen increased interest as traditional language models, while powerful, are inadequate when… →
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A Web-Based Tool to Perform a Values Clarification for Stroke Prevention in Patients With Atrial Fibrillation: Design and Preliminary Testing Study
CONCLUSIONS: Visual aids can modestly affect decision confidence and perceptions regarding the benefits of OAC but do not significantly alter decision certainty in a scenario where the guidelines do not recommend for or against OAC. Future work should determine the role of a gauge versus icon array visual for decision-making in stroke prevention in AF. →
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Trajectories of Irritability Improvement in Depressed Adolescents Treated With 1 Hz and 10 Hz Transcranial Magnetic Stimulation
Objective: Irritability is a debilitating, transdiagnostic symptom in adolescents spanning internalizing and externalizing disorders, and early reduction in irritability with antidepressant treatments has been seen as a positive prognostic sign in depression recovery. There are substantial knowledge gaps regarding how transcranial magnetic stimulation (TMS) treatments impact irritability. →
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How to do SEO right in 2025 (hint: most companies get it wrong)
Hello and welcome to The GTM Newsletter by GTMnow – read by 50,000+ to scale their companies and careers. GTMnow shares insight around the go-to-market strategies responsible for explosive company growth. GTMnow highlights the strategies, along with the stories from the top 1% of GTM executives, VCs, and founders behind these strategies and companies. Over… →
