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Molecular characterization and predictors of relapse in patients with Ph + ALL after frontline ponatinib and blinatumomab
CONCLUSIONS: WBC ≥ 70 × 10⁹/L is a high-risk feature in patients with Ph + ALL receiving frontline blinatumomab and ponatinib and may supersede the prognostic importance of baseline molecular features. Alternative frontline treatment strategies may be needed for these patients to reduce the risk of relapse and improve long-term outcomes. →
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Synergistic Enhancement of Compromised Skin Radiance: A Clinical Investigation of Prinsepia utilis Royle Polysaccharides and Nonapeptide Co-Application
CONCLUSION: PCA analysis revealed PUR9-2 uniquely modulated gene expression compared to PURP and EQ9. Functional enrichment analysis based on Gene Ontology (GO) demonstrated PUR9-2 restored UVA-suppressed TNFAIP3 and CRNN gene. The results of RT-PCR also indicated that PUR9-2 enhanced skin barrier integrity in 3D models via upregulated expression of FLG, LOR, and DSG1. The Chou-Talalay… →
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What GenAI Tools Can and Can’t Do for Presentations
Carolyn Geason-Beissel/MIT SMR | Getty Images As generative AI emerges as an easy way to perform computer-generated research, writing, and editing all in one fell swoop, it’s tempting to marvel at how it might improve one of the harder parts of leadership: creating convincing presentations to sell ideas to various constituencies. We’re entering a new… →
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Philosophy Eats AI: What Leaders Should Know
Ethics isn’t the only philosophical issue that organizations need to grapple with when developing and deploying AI. In fact, ethics and “responsible AI” are only a small part of the philosophical perspectives informing and guiding AI’s production, utility, and use. In this insightful video, MIT Sloan’s Michael Schrage and MIT Sloan Management Review’s David Kiron… →
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Coding Agents See 75% Surge: SimilarWeb’s AI Usage Report Highlights the Sectors Winning and Losing in 2025’s Generative AI Boom
As generative AI continues to redefine digital workflows across industries, SimilarWeb’s ‘AI Global Report: Global Sector Trends on Generative AI’ (ending May 9, 2025) offers a comprehensive snapshot of shifting user engagement patterns. The data-driven report highlights notable growth in coding agents, disruptive impacts on EdTech, and an unexpected downturn in Legal AI platforms. Here… →
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Google DeepMind Introduces AlphaEvolve: A Gemini-Powered Coding AI Agent for Algorithm Discovery and Scientific Optimization
Algorithm design and scientific discovery often demand a meticulous cycle of exploration, hypothesis testing, refinement, and validation. Traditionally, these processes rely heavily on expert intuition and manual iteration, particularly for problems rooted in combinatorics, optimization, and mathematical construction. While large language models (LLMs) have recently demonstrated promise in accelerating code generation and problem solving, their… →
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Rime Introduces Arcana and Rimecaster (Open Source): Practical Voice AI Tools Built on Real-World Speech
The field of Voice AI is evolving toward more representative and adaptable systems. While many existing models have been trained on carefully curated, studio-recorded audio, Rime is pursuing a different direction: building foundational voice models that reflect how people actually speak. Its two latest releases, Arcana and Rimecaster, are designed to offer practical tools for… →
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Meta AI Introduces CATransformers: A Carbon-Aware Machine Learning Framework to Co-Optimize AI Models and Hardware for Sustainable Edge Deployment
As machine learning systems become integral to various applications, from recommendation engines to autonomous systems, there’s a growing need to address their environmental sustainability. These systems require extensive computational resources, often running on custom-designed hardware accelerators. Their energy demands are substantial during training and inference phases, contributing to operational carbon emissions. Also, the hardware that… →
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Transdiagnostic Cognitive Remediation Therapy for Patients with Eating Disorders: A Randomized Controlled Trial
Background/Objectives: Eating disorders (EDs) are associated with cognitive inefficiencies related to cognitive flexibility, central coherence, and inhibition. Transdiagnostic cognitive remediation therapy (TCRT) is a new adaption of cognitive remediation therapy aimed at addressing these difficulties across ED diagnoses. This study investigates the effects of TCRT as an adjunctive treatment for patients with EDs on cognitive… →
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Effects of probiotic and vitamin D co-supplementation on migraine index, quality of life, and oxidative stress in adults with migraine headache: a randomized triple-blinded clinical trial
CONCLUSION: This trial showed that probiotic plus vitamin D supplementation can favorably improve MI as well as serum levels of NO in adult patients with migraine. Further research on mechanisms through which the supplementation was effective on MI is warranted. →
