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  • The effectiveness of care coordination on medication adherence among high-need, high-cost commercially insured beneficiaries: A randomized controlled trial

    28 апреля, 2026

    CONCLUSIONS: We found that care coordination did not improve medication adherence in HNHC beneficiaries. Our results align with prior studies and emphasize the challenges of improving adherence within a complex HNHC beneficiary population. →

    Clinical Trials
  • Heart Attack Education and EMS Response in High-Risk, Low EMS Usage Areas: A Stepped-Wedge Cluster-Randomized Trial

    27 апреля, 2026

    CONCLUSIONS AND RELEVANCE: In this community ACS education trial conducted in high-risk regions, the intervention did not improve EMS use or prehospital care-seeking. External contextual factors, including the COVID-19 pandemic and natural disasters, appeared to influence patient behavior and may have attenuated intervention effects, highlighting the complexity of achieving behavioral change through community education alone. →

    Clinical Trials
  • Influence of the Hardness of Insoles on the Abductor Hallucis Muscle in Baxter’s Entrapment: A Cross-Over Randomized Study

    27 апреля, 2026

    Background: The etiology and diagnosis of heel pain are complex and multifactorial, and it has been reported that Baxter’s entrapment is responsible for up to 20% of foot disorders. The most conservative treatment of Baxter’s entrapment has been the use of custom insoles. Electromyography was considered an effective test to assess muscle activity. The aim… →

    Clinical Trials
  • Comparative efficacy and safety of platelet-rich plasma (PRP), injectable platelet-rich fibrin (i-PRF) and concentrated growth factors (CGF) for female pattern hair loss (FPHL): a prospective multicenter randomized clinical trial

    27 апреля, 2026

    CONCLUSIONS: CGF and i-PRF demonstrated superior efficacy in increasing TAHC in FPHL patients. The i-PRF group had the lowest adverse event rate. VEGF levels may play a potential role in promoting hair growth. →

    Clinical Trials
  • Development and validation of standard-criteria and age-corrected nomograms for post-stroke cognitive impairment risk stratification

    27 апреля, 2026

    CONCLUSION: The developed dual nomograms, incorporating readily accessible clinical and imaging predictors, offer robust and practical tools for early risk stratification of PSCI in acute ischemic stroke survivors, facilitating targeted interventions. →

    Clinical Trials
  • Glycemic Status and Effect of Immediate Intensive Statin on Mild Ischemic Stroke: A Subgroup Analysis of the INSPIRES Trial

    27 апреля, 2026

    CONCLUSIONS: Patients without T2DM derived greater benefit in functional outcomes from immediate-intensive statin after ischemic stroke than those with T2DM. →

    Clinical Trials
  • Treatment effect modifiers of virtual reality-based versus standard cognitive behavioral therapy for paranoia in schizophrenia spectrum disorders: an exploratory moderator analysis of clinical and demographic characteristics in the FaceYourFears trial

    27 апреля, 2026

    CONCLUSIONS: This exploratory study generates hypotheses for future research, including VR-CBTp’s potential to engage individuals with high avolition. Given the modest effects and largely nonsignificant findings, both CBTp and VR-CBTp appear suitable for a wide range of individuals with paranoia, highlighting the importance of considering patient preferences. →

    Clinical Trials
  • High expression of low-risk hpv in nasal inverted papilloma and its response to interferon therapy

    27 апреля, 2026

    Objective:To investigate the expression of HPV 6/11 in NIP tissues and evaluate the adjuvant therapeutic effect of interferon-α gel on HPV-positive NIP patients. Methods:Forty-two newly diagnosed Nasal Inverted Papilloma(NIP) patients were included, and the expression of HPV6/11 in tissues was detected using fluorescence in situ hybridization with specific probes. Twenty-two HPV-positive patients were randomly divided… →

    Clinical Trials
  • Neoadjuvant chemotherapy for soft-tissue sarcoma of the extremities: A post-hoc Sarculator-based risk analysis of the EORTC 62961-ESHO 95 randomized trial

    27 апреля, 2026

    CONCLUSIONS: This analysis of ESTS from a randomized trial confirmed the previously reported OS benefit by adding RHT to NAC. Although patients with higher predicted risk seemed to benefit more from the combined treatment, these findings do not suggest that treatment decisions should be based on risk estimates alone, supporting the use of RHT combined… →

    Clinical Trials
  • Effect of a DBT-Informed Dyadic Intervention (Better Together) on Psychosocial Outcomes in Colorectal Cancer Patient-Spouse Dyads: A Randomized Controlled Trial

    26 апреля, 2026

    CONCLUSIONS: The BT program effectively improved both individual and dyadic outcomes, with patients benefiting immediately in psychological domains and caregivers exhibiting delayed improvements in relational outcomes during the follow-up period. These findings support implementing phased, role-sensitive dyadic interventions that address the distinct temporal needs of patients and caregivers in cancer care. →

    Clinical Trials
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