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10 GTM Campaign Plays Startups Are Using to Build Pipeline in 2025
Building pipeline is one of the toughest challenges for early-stage startups. What works for one company rarely works the same for another. Yet across dozens of Seed to Series A teams, we’ve noticed a handful of repeatable campaign plays that consistently generate conversations and conversions. Here are 10 of the campaign strategies that are proving… →
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IBM Released new Granite 4.0 Models with a Novel Hybrid Mamba-2/Transformer Architecture: Drastically Reducing Memory Use without Sacrificing Performance
IBM Releases Granite 4.0 Models with Novel Hybrid Mamba-2/Transformer Architecture IBM has introduced Granite 4.0, an open-source family of large language models (LLMs) that utilizes a hybrid Mamba-2/Transformer architecture. This innovative design significantly reduces memory usage while maintaining performance quality. The models include: Granite-4.0-H-Small: 32B total, ~9B active (hybrid MoE) Granite-4.0-H-Tiny: 7B total, ~1B active… →
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A Novel Dermocosmetic Routine Containing Vitamin B3 and 2-Mercaptonicotinyl Glycine Significantly Improves Melasma After 3 Months of Daily Use
CONCLUSIONS: Both DC routine and KT significantly improved melasma after 3 months of use. DC further improved melasma when replacing KT for 3 further months, with similar results when used alone for 6 months. →
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Role of Latissimus Dorsi-Thoracolumbar Fascia Complex Stretching on Pain and Pain-Related Parameters in Patients With Chronic Low Back Pain: A Randomised Clinical Trial
CONCLUSION: The results of this study suggest that stretching the LD-TLF complex may be a beneficial addition to the conventional physiotherapy approach for patients with CLBP. Specifically, LD-TLF complex stretching, when used in combination with conventional physiotherapy, appears to provide improved pain thresholds, decreased pain sensitivity and pain during activity, as well as reduced disability… →
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Efficacy of direct adductor canal block in pain control and sparing opioid consumption after total knee arthroplasty: a randomized controlled trial
CONCLUSION: Intraoperative direct ACB demonstrated an opioid-sparing effect when combined with PAI. By performing ACB intraoperatively, no additional space, cost, or manpower was required, and patients did not need an additional catheter for pain control. Direct ACB is a simple and safe procedure that can facilitate recovery after TKA. →
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The SUGAR handshake intervention to prevent hypoglycaemia in elderly people with type 2 diabetes: process evaluation within a pragmatic randomised controlled trial
CONCLUSIONS: This process evaluation highlights the SUGAR Handshake’s potential for broader implementation and scale-up. By addressing identified barriers, future educational interventions may enhance adherence, improve patient outcomes, and advance hypoglycaemia management in diabetes care. →
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Comparison of visual quality and optical zones after TransPRK, SMILE, and FS-LASIK myopia correction procedures
CONCLUSIONS: TransPRK has good postoperative visual quality, but its advantages may be mediated by its larger optical zone design. In terms of night vision performance, SMILE surgery can effectively preserve the biomechanical properties of the cornea, while FS-LASIK achieved comparable 6-month acuity; we did not assess time-to-recovery. Selection of surgical modality should be individualized based… →
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Evaluating the role of montelukast on doxorubicin-induced cardiotoxicity in breast cancer patients
CONCLUSION: The incorporation of ML into AC led to a substantial decrease in cardiac biomarkers confirming the feasibility of incorporating ML in individuals with breast cancer as an auxiliary treatment to prevent DOX-induced cardiotoxicity. Trial registration ClinicalTrials.gov: NCT05959889. →
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ServiceNow AI Releases Apriel-1.5-15B-Thinker: An Open-Weights Multimodal Reasoning Model that Hits Frontier-Level Performance on a Single-GPU Budget
ServiceNow AI Releases Apriel-1.5-15B-Thinker: An Open-Weights Multimodal Reasoning Model that Hits Frontier-Level Performance on a Single-GPU Budget Understanding the Target Audience The target audience for the ServiceNow AI model release includes AI researchers, data scientists, business managers, and IT decision-makers who are interested in implementing advanced AI solutions. Their pain points often revolve around the… →
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Change Management: How to Avoid the Hero Trap
Carolyn Geason-Beissel/MIT SMR | Getty Images The amount of change coming at leaders right now may feel unprecedented, given today’s political and technical landscape. But amid significant disruptions, such as artificial intelligence tools, deep-tech innovations, novel fintech platforms, and geopolitical shifts, an organization’s capacity to grow depends on its capacity to change constantly. Success also… →