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Comparison of Oral Desensitization with Heated Cow’s Milk Products with Conventional Desensitization Method in Children with Cow’s Milk Allergy
Cow’s milk allergy (CMA) is one of the most prevalent Immunoglobulin E (IgE)-dependent food allergies in children. Currently, the only accepted treatment for food allergy is avoiding the relevant allergen. The purpose of this study is to investigate the immunological changes following the consumption of heated cow’s milk products compared to the usual method of… →
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How Grocery Retail Innovations Change Customer Behavior
Nick Lowndes/Ikon Images Grocery retailers are racing to reinvent the customer experience. As omnichannel shopping becomes the norm — with 90% of consumers now purchasing food through both online and offline channels — grocers are deploying new tactics to attract shoppers, build loyalty, and drive profitability. But do these customer experience investments actually pay off?… →
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Scaling GenAI: Get Big Value From Smaller Efforts
Related Reading M. Webster and G. Westerman, «Generate Value From GenAI With ‘Small t’ Transformations,» MIT Sloan Management Review, Jan. 22, 2025. Despite two years of broad experimentation, most companies aren’t seeing the large-scale GenAI transformations they initially envisioned. The challenge isn’t the technology’s potential — it’s understanding how to generate real value at three… →
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The Economic Price We Pay for War
The consequences of war are devastating. While it’s often the most-visually striking results that grab our attention, in examining the costs of war, it is crucial to understand how it affects the economy. “Of course, economic consequences do not encompass all of the misery that war inflicts on people,” says Efraim Benmelech, a Kellogg professor… →
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Caffeine exacerbates exercise-induced gut cell damage and is influenced by ADORA2A genotype but not CYP1A2 genotype: A preliminary study
Endurance exercise may be associated with acute damage to intestinal epithelial cells. The effect of caffeine supplementation, and whether this is influenced by common genetic polymorphisms (ADORA2A: rs5751876 and CYP1A2: rs762551), is not currently known. Participants (n = 18 men and women) ingested caffeine (3 mg/kg body mass) or placebo 45 min before cycling (20… →
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TRPM8 Agonist (Cryosim-1) Cream for Chronic Prurigo: A Randomized, Vehicle-controlled Trial
Chronic prurigo (CP) is a distressing dermatological condition lacking effective topical therapies. This randomized, double-blind, vehicle-controlled trial evaluated the efficacy and safety of Cryosim-1, a TRPM8 agonist cream, in 30 adults with CP. Participants were assigned to apply Cryosim-1 0.1%, 0.5%, or vehicle cream 3 times daily for 4 weeks. Both active formulations significantly reduced… →
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Effects of psycho-cardiology care on psychological and clinical outcomes among primary aldosteronism patients undergoing adrenal vein sampling: A randomized controlled study
Adrenal vein sampling (AVS) is considered the gold standard for the subtyping diagnosis of primary aldosteronism (PA), which is essential for preventing adverse cardiovascular outcomes. Nevertheless, the AVS procedure might induce anxiety in patients with PA because of discomfort and the uncertainty of the outcome. Therefore, this study aimed to assess the effectiveness of psycho-cardiology… →
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Tripartite strategy for dual reduction of radiation and iodine dose in obese CCTA: High-iodine contrast, 80 kVp, and deep learning reconstruction
Coronary CT angiography (CCTA) in obese patients is challenging due to high radiation exposure, elevated iodine load, and increased image noise. We evaluated a tripartite low-dose strategy combining high-iodine-concentration contrast media (HCM, 400 mgI/mL), 80-kVp scanning, and deep learning image reconstruction (DLIR) in obese patients (BMI ≥30 kg/m2) to simultaneously reduce radiation and iodine dose… →
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Clinical application of Chester Step Test in developing personalized exercise prescription in patients with type 2 diabetes: A single-blind, randomized controlled trial
CONCLUSIONS: Under free-living conditions, the personalized exercise prescription based on CST effectively reduced glycemic variability in T2D patients. →
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An extended cost-effectiveness analysis of decentralised TB diagnostic testing with Molbio Truenat MTB/RIF versus hub-and-spoke GeneXpert MTB/RIF in Mozambique and Tanzania
CONCLUSION: The intervention reduced patient costs and improved outcomes across SES groups. Decentralised TB testing with the Molbio Truenat platform is both cost-saving and more effective and cost-effective compared with a hub-and-spoke model in Mozambique and Tanzania. →
