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A case-control study investigating the impact of gradient pressure therapy on chemotherapy-induced peripheral neuropathy symptoms and daily activities in paclitaxel-treated patients
CONCLUSION: Gradient pressure therapy effectively reduces symptoms of paclitaxel-induced peripheral neuropathy, improving patients’ daily activities. This intervention is recommended for clinical promotion and application. →
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Parent-child agreement in reporting somatic distress, gastrointestinal symptoms, mental health, and general health in girls with functional abdominal pain
CONCLUSION: Findings indicated good parent- and child agreement for gastrointestinal and general somatic symptoms, but lower agreement for mental health and general health. →
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The GTM Moat Series: Distribution is the Final Moat
Hello and welcome to The GTMnow Newsletter – the media brand of VC firm, GTMfund. Build, scale and invest with the best minds in tech. This is Part II of a series on how to build your GTM moat. You can find Part I on brand here. In AI, your product won’t be your moat… →
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Adapted Safety Plans to Address Self-Harm and Suicide Behaviours in Autistic Adults: single arm feasibility trial and external pilot RCT
CONCLUSION: Autism Adapted Safety Plans are a potentially valuable intervention for autistic adults, provided that the process of creating it is flexible and sensitive to individual needs. The parameters of a future definitive trial of the clinical and cost-effectiveness of Autism Adapted Safety Plans are achievable, with minor recommended adaptations. Further testing of the Autism… →
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Effect of tricalcium silicate-based intracanal dressing on antibacterial-antifungal activity and postoperative pain intensity after non-surgical endodontic retreatment: randomized controlled clinical trial
CONCLUSIONS: Both materials were effective in reducing microbial load; however, calcium hydroxide demonstrated superior antibacterial efficacy. Antifungal activity and postoperative pain outcomes were comparable between the groups. →
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Vonoprazan attenuates proteinuria in diabetic kidney disease through potential direct renal mechanism
Our study investigates the effect of vonoprazan on albuminuria in diabetic kidney disease (DKD) patients compared to lansoprazole through a randomized controlled trial. Participants were randomized to receive either lansoprazole 30 mg or vonoprazan 20 mg. Specifically, 100 patients were included for H. pylori eradication, and 40 patients for other indications. The albumin/creatinine ratio (ACR)… →
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Randomized crossover trial of hand and hydrostatic casting for custom lower limb prosthetic sockets: Assessing socket comfort and fabrication time
The aim of this study was to compare diagnostic sockets made by hand casting and standing hydrostatic pressure casting in persons with lower limb amputation. This multi-site, single-masked, randomized crossover trial (ClinicalTrials.gov NCT04141748) involved a prosthetist at each site taking one cast by hand (H) and another using hydrostatic casting (S). The process of casting,… →
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Automated Oxygen Delivery in Home Setting for Patients with COPD on Long-Term Oxygen Therapy — A Randomized Crossover Feasibility Trial
CONCLUSION: Automated oxygen titration is feasible in the home setting, achieving more time with normoxia, but it required a wide flow range and continuous SpO2 monitoring. The patients reported a clinically relevant reductions in COPD symptoms measured with CCQ. The clinical importance of controlling SpO(2) needs to be examined in a larger study. →
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Comparative analysis of postoperative results of various methods of treatment of inguinal hernias
To assess and compare the long-term postoperative complications, postoperative pain incidences, and hernia recurrence rates following surgery for inguinal hernias using different surgical approaches, namely transabdominal preperitoneal (TAPP), TAPP with the internal ring suturing (TAPP-IRS), Liechtenstein technique, and Shouldice technique. This study is a multicentre clinical trial that involves 302 patients ranging from 18 to… →
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Effectiveness of transcranial direct current stimulation on emotional instability and impulsivity in atypical depression and bipolar II disorder
Atypical depressive disorder and bipolar disorder often present with symptoms like emotional instability and impulsive behaviors. Various treatments, both pharmaceutical and non-pharmacological, are employed to manage these conditions. Transcranial direct current stimulation (tDCS) is a modern treatment option that has shown promise with minimal side effects. This study aims to compare the effectiveness of tDCS… →
