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The Influence of Berberine on Vascular Function Parameters, Among Them VEGF, in Individuals with MAFLD: A Double-Blind, Randomized, Placebo-Controlled Trial
CONCLUSIONS: BBR appears to be a safe and promising adjunct in MAFLD therapy, potentially exerting reparative effects through VEGF modulation and vascular support. Further research is warranted to confirm its long-term impact and elucidate underlying protective mechanisms. →
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A Pilot Randomized Controlled Trial of Extracorporeal Vaginal Peflex Weights for Enhancing Pelvic Floor Function and Relieving Stress Urinary Incontinence
CONCLUSIONS: Peflex weights effectively reduce SUI symptoms and improve muscle power and endurance, with high user satisfaction. However, there was no significant difference in the main outcome measure (ICIQ-UI-SF) between the Peflex and control groups. Further research is needed to identify which patients benefit most from this treatment. →
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Successful implementation of stroke risk screening for sickle cell anemia in the DISPLACE study: results of a cluster randomized trial
CONCLUSIONS: Our intervention approach in DISPLACE significantly improved stroke risk screening for children with SCA, with procedure-patient tracking emerging as an important component for improving care. →
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Examining the effect of universal testing and treatment strategies for HIV prevention in Zambia and South Africa: generalizing the results of the HPTN 071 (PopART) trial
CONCLUSIONS: PopART interventions are estimated to be more protective in the population of interest than observed in the HPTN071 sample. These results partially explain the unexpected finding in arm A, providing further support for UTT strategies for HIV prevention. This analysis also highlights the importance of considering heterogeneous treatment effects among population subgroups when measuring… →
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De-Escalation Dual Antiplatelet Strategy in Stabilized Myocardial Infarction Patients With Diabetes Mellitus
CONCLUSIONS: In MI patients with DM, 1-month unguided de-escalation to clopidogrel after ticagrelor-based DAPT was associated with clinical benefit without increasing ischemic risk. These results warrant further prospective validation. →
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Tai chi or cognitive behavioural therapy for treating insomnia in middle aged and older adults: randomised non-inferiority trial
CONCLUSION: Tai chi was inferior to CBT-I at month 3 but non-inferior at month 15. This finding supports the use of tai chi as an alternative approach for the long term management of chronic insomnia in middle aged and older adults. →
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A rapid time-resolved host gene expression signature predicts responses to antibiotic treatment in neonatal bacterial sepsis
Sepsis is a leading cause of mortality and morbidity in neonates yet remains difficult to diagnose. This leads to widespread empiric antibiotic therapy, which can facilitate the development of antimicrobial resistance. How the dysregulated host response to infection and sepsis evolves after antibiotic treatment is poorly understood. Temporal gene expression in neonates with microbiologically confirmed… →
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What Retailers Must Get Right This Holiday Season
Carolyn Geason-Beissel/MIT SMR | Getty Images If you’ve been in a retail store recently, you’ve probably seen long checkout lines, hard-to-find help — and disgruntled shoppers. Online shopping shows evidence of similar stress, as frustrated consumers abandon digital shopping carts. A telling data point: Customer experience indices have been declining, as seen in drops over… →
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Effect of ADOPT model-based nursing intervention on self-management ability in patients with middle and low rectal cancer after sphincter-preserving surgery
CONCLUSION: ADOPT model-based nursing intervention significantly improved self-management ability and quality of life while reducing postoperative complications in patients with middle and low rectal cancer after sphincter-preserving surgery. This structured approach provides evidence for incorporating ADOPT into clinical practice to optimize postoperative care. →
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A probiotic containing L. plantarum and P. acidilactici strains for treating upper respiratory infection in children aged 6 months to 5 years: a randomized, double-blind trial
CONCLUSION: Intervention with this probiotic formula was associated with a shorter duration of fever and pain/discomfort in pediatric URIs with pharyngitis. →
