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Exploring MOLMO VLM
In the fast-paced world of artificial intelligence, a new model is making waves for its innovative approach and impressive performance: MOLMO (Multimodal Open Language Model), developed by the Allen Institute for AI (Ai2). Unlike many of today’s powerful vision-language models, which are often proprietary and closed-source, MOLMO stands out as a shining example of open-source… →
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A multicenter phase 2 trial in children and young adults with newly diagnosed T-ALL: ALL-T11/ T-ALL-211-U from the Japan Children’s Cancer Group and the Japan Adult Leukemia Study Group
T-cell acute lymphoblastic leukemia (T-ALL) accounts for approximately 10-15% of childhood ALL, with its incidence increasing during the adolescent and young adult (AYA) period. The Japan Children’s Cancer Group (JCCG) and the Japan Adult Leukemia Study Group (JALSG) conducted the ALL-T11/T-ALL-211-U clinical trial in newly diagnosed T-ALL patients under 25 years of age. The treatment… →
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Carfilzomib-lenalidomide-dexamethasone versus lenalidomide-dexamethasone in patients with newly diagnosed myeloma ineligible for autologous stem-cell transplantation (EMN20): a randomised, open-label, multicentre, phase 3 trial
BACKGROUND: Before the introduction of daratumumab-lenalidomide-dexamethasone as a first-line treatment for patients with newly diagnosed transplant-ineligible multiple myeloma, lenalidomide-dexamethasone was a standard of care. We aimed to explore whether addition of the second-generation proteasome inhibitor carfilzomib to lenalidomide-dexamethasone improved the rates of measurable residual disease (MRD) negativity and progression-free survival. →
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Induction therapy with bortezomib, melphalan, and prednisone followed by lenalidomide and dexamethasone versus carfilzomib, lenalidomide, and dexamethasone with or without daratumumab in older, fit patients with newly diagnosed multiple myeloma (GEM-2017FIT): a phase 3, open-label, multicentre, randomised clinical trial
BACKGROUND: Triplet and quadruplet regimens based on bortezomib, melphalan and prednisone (VMP) and lenalidomide and dexamethasone (Rd) with anti-CD38 antibodies are potential treatments for transplant-ineligible patients with newly diagnosed multiple myeloma. However, the high risk of toxic effects in this population requires frailty-based therapy adaptation. We aimed to compare the response of carfilzomib-based triplet and… →
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MoE Architecture Comparison: Qwen3 30B-A3B vs. GPT-OSS 20B
«`html MoE Architecture Comparison: Qwen3 30B-A3B vs. GPT-OSS 20B This article provides a technical comparison between two recently released Mixture-of-Experts (MoE) transformer models: Alibaba’s Qwen3 30B-A3B (released April 2025) and OpenAI’s GPT-OSS 20B (released August 2025). Both models represent distinct approaches to MoE architecture design, balancing computational efficiency with performance across different deployment scenarios. Model… →
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Google DeepMind Introduces Genie 3: A General Purpose World Model that can Generate an Unprecedented Diversity of Interactive Environments
«`html Google DeepMind Introduces Genie 3: A General Purpose World Model that can Generate an Unprecedented Diversity of Interactive Environments Understanding the Target Audience The target audience for Genie 3 includes AI researchers, game developers, robotics engineers, and educators. Their primary pain points involve the limitations of current simulation tools, the need for rapid prototyping,… →
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Formalize Escalation Procedures to Improve Decision-Making
Michael Austin/thesipot.com The CEO of a fast-growing pharmaceutical startup recently forwarded us an email exchange he had had with his chief financial and chief commercial officers. It seems that the CCO had surprised both the CEO and CFO by proposing to spend more than $450,000 to retain an outside agency. The CFO immediately fired off… →
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Blending electronic techniques with traditional teaching methods to enhance chest X-ray interpretation in medical students
CONCLUSION: Both traditional and blended E-learning improved students’ chest x-ray interpretation skills. However, the study found that the group receiving electronic training showed more noticeable positive changes, significantly increasing students’ self-confidence. A combination of E-learning and traditional methods significantly improves chest radiograph interpretation among young students. Early integration of E-learning for CXR interpretation in the… →
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Addiction Consult Services, Mortality, and Acute Care Utilization in Inpatients With Opioid Use Disorder: A Secondary Analysis of a Cluster Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this prespecified secondary analysis of a cluster randomized clinical trial, postdischarge ED visits decreased with the CATCH program, highlighting the potential of hospital-based addiction consult services to address needs of patients with opioid use. Nonetheless, high rates of acute care utilization and mortality persisted, underscoring the need for comprehensive care strategies… →
