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Insights Into How Digital Health Interventions Shape Outcomes for Emerging Adults Living With Type 1 Diabetes: Qualitative Realist Process Evaluation
CONCLUSIONS: A multicomponent, text message-based digital intervention could support emerging adults living with T1D during their transition to adult care by enhancing their knowledge and motivation for self-management. Participant subgroups responded differently to various intervention components, which highlights that one-size-fits-all approaches are likely inadequate. Digital interventions should be developed and studied in a variety of… →
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Rapid Brain Adaptation to Hearing Amplification: A Randomized Crossover Trial of Personal Sound Amplification Products
Understanding speech in noise is a common challenge for older adults, often requiring increased listening effort that can deplete cognitive resources and impair higher-order functions. Hearing aids are the gold standard intervention for hearing loss, but cost and accessibility barriers have driven interest in alternatives such as Personal Sound Amplification Products (PSAPs). While PSAPs are… →
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How to Build a Complete End-to-End NLP Pipeline with Gensim: Topic Modeling, Word Embeddings, Semantic Search, and Advanced Text Analysis
«`html How to Build a Complete End-to-End NLP Pipeline with Gensim: Topic Modeling, Word Embeddings, Semantic Search, and Advanced Text Analysis In this tutorial, we present a complete end-to-end Natural Language Processing (NLP) pipeline built with Gensim and supporting libraries, designed to run seamlessly in Google Colab. It integrates multiple core techniques in modern NLP,… →
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The psychological impact of the disclosure of the diagnosis of Alzheimer’s disease on informal caregivers
INTRODUCTION: Receiving an Alzheimer’s disease (AD) diagnosis can be a distressing experience, for both the individual with the condition and the family. This cross-sectional study explored whether the disclosure of AD diagnosis generated post-traumatic stress symptoms (PTSSs) in caregivers and how this affected their psychological well-being. →
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An Open-Label, Single-Arm, Phase II Trial of Sintilimab Plus Anlotinib for Metastatic Non-Small Cell Lung Cancer After First-Line PD-(L)1 Inhibitor
CONCLUSION: Sintilimab combined with anlotinib exhibited favorable antitumor activity and tolerable toxicity in post-anti-PD-(L)1 therapy of metastatic NSCLC patients, supporting further randomized controlled trials. →
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De-escalated adjuvant radiotherapy versus standard adjuvant treatment for human papillomavirus-associated oropharyngeal squamous cell carcinoma (MC1675): a phase 3, open-label, randomised controlled trial
BACKGROUND: Standard adjuvant chemoradiotherapy (60-66 Gy) following surgery for HPV-associated oropharyngeal squamous cell carcinoma has excellent oncological control but high treatment morbidity. We aimed to compare toxicity of a 30-36 Gy regimen of de-escalated adjuvant radiotherapy and standard of care treatment. →
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Meet Chatterbox Multilingual: An Open-Source Zero-Shot Text To Speech (TTS) Multilingual Model with Emotion Control and Watermarking
«`html Meet Chatterbox Multilingual: An Open-Source Zero-Shot Text To Speech (TTS) Model with Emotion Control and Watermarking Target Audience Analysis The target audience for Chatterbox Multilingual includes AI researchers, developers, content creators, and businesses interested in implementing multilingual text-to-speech solutions. Pain points for this audience often involve the high costs associated with commercial TTS systems,… →
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Biomni-R0: New Agentic LLMs Trained End-to-End with Multi-Turn Reinforcement Learning for Expert-Level Intelligence in Biomedical Research
«`html Biomni-R0: New Agentic LLMs Trained End-to-End with Multi-Turn Reinforcement Learning for Expert-Level Intelligence in Biomedical Research The Growing Role of AI in Biomedical Research The field of biomedical artificial intelligence is evolving rapidly, with increasing demand for agents capable of performing tasks that span genomics, clinical diagnostics, and molecular biology. These agents must reason… →
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Strategic Alignment Reconciles Purpose and Profitability
Otto Dettmer/Ikon Images For many leadership teams and boards, discussions about a business’s corporate purpose are mired in conflict. All too often, the participants position purpose and profit as opposing priorities — and, in doing so, sideline purpose as an indispensable driver of strategic alignment and sustainable performance. A corporation with no avowed purpose other… →
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The Effect of a Psychodrama-Based Group Intervention on Anger and Self-Injurious Behaviors in Adolescents Diagnosed with Substance Use Disorder: A Randomized Controlled Trial
CONCLUSION: Psychodrama group work significantly reduced anger and self-injury behaviors in adolescents with substance use disorders. Integrating psychodrama into treatment is recommended to improve care outcomes. →
