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Trajectories of Angina After Initial Invasive vs Conservative Strategy for Chronic Coronary Disease
CONCLUSIONS: Patients with chronic coronary disease and angina experienced diverse symptom trajectories, ranging from rapid resolution to severe or persistent angina. A greater proportion of conservatively managed patients experienced unfavorable angina patterns over 2 years compared with those treated invasively. When health status is monitored over time, such patterns may help identify patients with persistent… →
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5-Year Outcomes With a Novel Coronary Sirolimus-Eluting Bioresorbable Scaffold: The NeoVas Randomized Trial
CONCLUSIONS: At 5-year follow-up, target lesion failure and stent thrombosis rates were comparable after NeoVas BRS and CoCr EES implantation in noncomplex lesions. However, comparability or the potential signs of harm of NeoVas BRS should be investigated in appropriately sized randomized trials in the future. (NeoVas Bioresorbable Coronary Scaffold Randomized Controlled Trial; NCT02305485). →
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Investigating Learning Effects Through the Implementation of Teledermatology Consultations Among General Practitioners in Germany: Mixed Methods Process Evaluation
CONCLUSIONS: TCs have been shown to be an effective method of education for GPs in terms of «learning on the job» in daily practice. The telemedicine approach seems to be an easily implementable and effective tool to support continuing medical education in the field of dermatology. Strategies could be developed to train GPs and medical… →
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Meet mmBERT: An Encoder-only Language Model Pretrained on 3T Tokens of Multilingual Text in over 1800 Languages and 2–4× Faster than Previous Models
Meet mmBERT: An Encoder-only Language Model Pretrained on 3T Tokens of Multilingual Text Meet mmBERT: An Encoder-only Language Model Pretrained on 3T Tokens of Multilingual Text in over 1800 Languages and 2–4× Faster than Previous Models Table of Contents Why was a new multilingual encoder needed? Understanding the architecture of mmBERT What training data and… →
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Building Advanced MCP (Model Context Protocol) Agents with Multi-Agent Coordination, Context Awareness, and Gemini Integration
Building Advanced MCP (Model Context Protocol) Agents with Multi-Agent Coordination, Context Awareness, and Gemini Integration In this tutorial, we will guide you through the process of building an advanced MCP (Model Context Protocol) Agent that is designed to operate smoothly in Jupyter or Google Colab environments. The focus is on real-world applicability, emphasizing multi-agent coordination,… →
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Maintaining independence at home after a fall: a process evaluation of the MAINTAIN multicomponent intervention for people living with dementia
CONCLUSIONS: MAINTAIN was both feasible and acceptable. Future studies should consider standardising multidisciplinary support, incorporating targeted falls-related anxiety support and establishing sustainable post-intervention maintenance strategies. Protocol adaptations, such as video consultations, showed promise in addressing workforce constraints. →
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Cerebellar Stimulation Modulates Reward Processing: A High-definition Transcranial Direct Current Stimulation Study
Reward processing involves several components, including reward anticipation, cost-effort computation, reward consumption, reward sensitivity, and reward learning. Recent research has highlighted the cerebellum’s role in reward processing. This study aimed to investigate the effects of cerebellar stimulation on reward processing using high-definition transcranial direct current stimulation (HD-tDCS). In this single-blind, randomized, sham-controlled study, 63 healthy… →
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NVIDIA AI Releases Universal Deep Research (UDR): A Prototype Framework for Scalable and Auditable Deep Research Agents
NVIDIA AI Releases Universal Deep Research (UDR): A Prototype Framework for Scalable and Auditable Deep Research Agents Understanding the Target Audience The target audience for NVIDIA’s Universal Deep Research (UDR) includes AI researchers, data scientists, business analysts, and enterprise decision-makers. These individuals are typically involved in high-value applications across various domains such as finance, healthcare,… →
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Erector Spinae Plane Block for Postoperative Analgesia in Laparoscopic Living-Donor Nephrectomy
CONCLUSIONS: Although erector spinae plane blocks applied under bilateral ultrasonographic guidance did not have any efficacy for pain relief in the first 24 hours postoperation, a decrease was found in analgesic consumption compared with the nonblock group. →
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Baidu Releases ERNIE-4.5-21B-A3B-Thinking: A Compact MoE Model for Deep Reasoning
Baidu Releases ERNIE-4.5-21B-A3B-Thinking: A Compact MoE Model for Deep Reasoning The Baidu AI Research team has released ERNIE-4.5-21B-A3B-Thinking, a new reasoning-focused large language model designed for efficiency, long-context reasoning, and tool integration. As part of the ERNIE-4.5 family, this model utilizes a Mixture-of-Experts (MoE) architecture with 21B total parameters but only 3B active parameters per… →