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Effectiveness of foam tooth brush on oral health status of children with attention deficit hyperactivity disorder — A randomized controlled trial
CONCLUSION: The foam toothbrush demonstrated superior efficacy in improving oral hygiene, particularly in children with the hyperactive type of ADHD. →
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A randomized controlled prospective study comparing surgical outcomes of median umbilical ligament lift-up and Veress needle entry techniques in gynecologic laparoscopic surgery
CONCLUSIONS: The MULU technique, based on anatomical guidance via the median umbilical ligament, is a safe and effective method for abdominal entry. It offers faster access and may reduce the risk of major complications, making it a viable alternative to conventional techniques. →
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Metformin for overweight and obese children and adolescents with bipolar spectrum and related mood disorders treated with second-generation antipsychotics: a randomised, pragmatic trial
BACKGROUND: Second-generation antipsychotics are widely used to treat patients with bipolar spectrum disorders and effectively manage mood symptoms but can often cause substantial weight gain and other metabolic alterations that elevate long-term risks of cardiovascular disease and premature mortality. Metformin has been shown to be safe and efficacious for ameliorating weight gain but has not… →
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To Reform Meritocracy, Put Character at the Center
Carolyn Geason-Beissel/MIT SMR | Getty Images The idea of meritocracy is under attack: It has been called a “myth,” a “sham,” a “trap,” a “tyranny,” and an “alibi for plutocracy.” While meritocracy, as historically and currently practiced, is clearly in need of reform, it is hard to accept the notion that it is so flawed… →
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Leaders at All Levels: AI Enables Innovation at Cascade Engineering
What happens when you deploy AI tools to enhance workers’ capabilities instead of replacing people? At Cascade Engineering, a $400 million plastics manufacturer, “physical AI” — the use of intelligent machinery alongside human problem solvers — is giving people more time to innovate. That workforce management tactic dovetails with CEO Christina Keller’s distributed leadership approach,… →
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Modulating Placebo Effects in Clinical Trials: Study Team Briefing to Optimize Drug-Placebo Differences
Clinical trials often face challenges with placebo effects that can mask actual drug effects. We evaluated whether briefing the study team members on placebo mechanisms influenced analgesia. In this study, we compared the analgesic effects of oxycodone and placebo in three groups of 32 subjects. The groups were treated by an untrained study team (Arm… →
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Rapid Late Gadolinium Enhancement Cardiac MRI in Real-World Clinical Practice: A Prospective Clinical Trial
Purpose To compare two rapid late gadolinium enhancement (LGE) cardiac MRI sequences-phase-sensitive inversion recovery (PSIR) single-shot true fast imaging with steady-state precession (TrueFISP) and motion-corrected TrueFISP PSIR (moco PSIR)-with the PSIR turbo fast low-angle shot (turboFLASH) sequence regarding image quality, localization, and quantification of LGE. Materials and Methods This prospective study included consecutive participants who… →
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Probiotic Supplementation Enhances the Effects of a Nutritional Intervention on Quality of Life in Women with Hashimoto’s Thyroiditis-A Double-Blind Randomised Study
Background: Hashimoto’s thyroiditis (HT) is characterised by chronic inflammation of the thyroid gland. The impact of a health-promoting diet and probiotics on health and quality of life, as well as on the anti-thyroid peroxidase antibody (anti-TPO), is increasingly being researched. However, the relevance of these factors to the course of HT is yet to be… →
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Synergistic Effects of Microencapsulated Polyphenols and Concurrent Training on Metabolic Health and Fitness in Overweight/Obese Adults with Prediabetes
Background/Objectives: Prediabetes markedly increases the risk of progression to type 2 diabetes. While exercise and dietary polyphenols independently enhance metabolic health, their combined and synergistic effects remain unclear. This randomized, single-blind, placebo-controlled trial investigated the synergistic effects of concurrent training and a microencapsulated persimmon-karonda polyphenol formulation on glycemic control and inflammatory outcomes in adults with… →
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Postoperative pain following root canal treatment with XP-Endo Finisher-assisted irrigant activation: a double-blind randomized controlled trial
CONCLUSIONS: The XP-Endo Finisher resulted in reduced early postoperative pain compared to needle irrigation at specific time points, although both methods showed similar outcomes in long-term pain resolution and analgesic consumption. Improved irrigant activation may influence short-term postoperative comfort. →
