Xin Gu April 27, 2024 Cancers (Basel). 2024 Apr 20;16(8):1589. doi: 10.3390/cancers16081589. ABSTRACT Pancreatic ductal adenocarcinoma (PDAC), one of the deadliest cancers, presents significant challenges in diagnosis and treatment due to its aggressive, metastatic nature and lack of early detection methods. A key obstacle in PDAC treatment is the highly complex tumor environment characterized by…
Pasquale Niscola April 27, 2024 Cancers (Basel). 2024 Apr 19;16(8):1563. doi: 10.3390/cancers16081563. ABSTRACT Myelodysplastic syndromes/neoplasms (MDSs) encompass a range of hematopoietic malignancies, commonly affecting elderly individuals. Molecular alterations in the hematopoietic stem cell compartment drive disease pathogenesis. Recent advancements in genomic profiling have provided valuable insights into the biological underpinnings of MDSs and have expanded…
Aakash Patel April 27, 2024 Cancers (Basel). 2024 Apr 18;16(8):1551. doi: 10.3390/cancers16081551. ABSTRACT Colorectal cancer (CRC) is the second leading cause of cancer deaths worldwide. Although the overall incidence of CRC is decreasing, the incidence of young-onset CRC, characterized by a diagnosis of CRC before age 50, is increasing. Outcomes for CRC patients are improving,…
Emilia Staniewska April 27, 2024 Cancers (Basel). 2024 Apr 18;16(8):1542. doi: 10.3390/cancers16081542. ABSTRACT INTRODUCTION: There is growing interest in the prognostic value of routinely performed pre-treatment blood test indices, such as the RDW or SII, with the latter combining the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR). These indices were shown to be prognostic for…