Clinical Trials
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The Effects of a Multidomain Lifestyle Intervention on Brain Function and Its Relation With Immunometabolic Markers and Intestinal Health in Older Adults at Risk of Cognitive Decline: Study Design and Baseline Characteristics of the HELI Randomized Controlled Trial
CONCLUSIONS: The HELI study aims to enhance our understanding of the working mechanisms of multidomain lifestyle interventions through its comprehensive characterization of central and peripheral markers. We intend to achieve this aim by assessing lifestyle intervention-induced changes in functional and structural MRI brain measures, as well as peripheral measures of the gut-immune-brain axis involved in…
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Effects of narrative nursing on delirium and outcomes in mechanically ventilated ICU patients: a randomized trial
CONCLUSION: A structured narrative nursing intervention reduced the incidence and duration of delirium among mechanically ventilated ICU patients, improved selected clinical outcomes, and increased patient satisfaction. Limitations include the single-center design, modest sample size, and limited blinding, which may introduce bias. Multicenter, adequately powered, prospectively registered randomized trials are warranted to confirm these findings.
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Heart rate variability biofeedback in adults with chronic spinal cord injury: a randomised feasibility study
CONCLUSIONS: With the proposed modifications implemented, the RCT is deemed feasible for investigating the effectiveness of a 10-week HRV-F intervention for adults with chronic SCI.
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Enhanced nursing and ganciclovir improve outcomes in paediatric Epstein-Barr Virus infectious mononucleosis: A Randomised Control Trial
CONCLUSIONS: Ganciclovir and good nursing improved paediatric Epstein-Barr virus infectious mononucleosis treatment.
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Redox-sensitive miRNAs and Humanin could mediate effects of exercise and astaxanthin on oxidative stress and inflammation in type 2 diabetes
Type 2 diabetes mellitus (T2DM) is driven by oxidative stress (OS) and inflammation (IF), accelerating disease progression. This study examined whether combined aerobic and resistance training (CT) and astaxanthin (AST) supplementation synergistically improve oxidant and inflammatory status as well as metabolic indices in T2DM, focusing on the mediatory role of Humanin (HN) and microRNAs (miRNA-122,…
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Dopamine versus norepinephrine in fluid-refractory septic shock among preterm neonates: a double-blind randomized controlled trial
The present study aims to compare the efficacy and safety of norepinephrine (NE) versus dopamine in achieving early (within 45 min of initiation) reversal of fluid-refractory septic shock in preterm neonates. A double-blind randomized controlled trial was conducted in a Level-III tertiary care hospital in Northern India. Fifty neonates born at a gestational age of…
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Pilot Study of Early Adoption of Automated Insulin Delivery in Underresourced Youth
CONCLUSION: Early initiation of AID is feasible and acceptable in youth with recently diagnosed T1D from underresourced populations who historically experience lower technology adoption and less optimal glycemic outcomes. Diabetes clinicians should consider providing tailored support and dedicated resources to families early in diagnosis with T1D to promote AID initiation and continued use.
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Efficacy and Safety of Methotrexate Administered by Oral and Subcutaneous Routes in Patients with Severe Psoriasis
CONCLUSION: The SC route of MTX administration is safer and more effective than the oral route in patients with severe psoriasis.
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2′-Fucosyllactose supplementation results in a transient improvement in gut microbial resilience after vancomycin use in adults with overweight or obesity: a randomized, double-blind, placebo-controlled intervention
Antibiotic-induced perturbations of the gut microbiome can be long-lasting and potentially affect host metabolic health. Strategies supporting microbial resilience are needed to mitigate the negative impact of antibiotics. We investigated the potential of 2′-fucosyllactose (2′-FL) supplementation after vancomycin use in a double-blind placebo-controlled randomized intervention among adults with overweight/obesity. Participants received oral vancomycin for seven…
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Effect of ketogenic diet plus dulaglutide on glucose and lipid metabolism in diabetes mellitus
Diabetes mellitus is a chronic disease with a high incidence worldwide and exclusive drug treatment has a limited effect. To investigate the effects of a ketogenic diet combined with dulaglutide on glucose and lipid metabolism in diabetic patients, a total of 104 patients with type 2 diabetes mellitus were randomly divided into a study group…