Clinical Trials
Category Added in a WPeMatico Campaign
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Effect of percutaneous release versus steroid injection among adults with trigger fingers: a randomized clinical trial
CONCLUSION: Percutaneous release of A1 pulley illustrated greater improvement in functional mobility with a moderate effect size and pain with a large effect size compared to steroid injection in trigger fingers. A multicenter trial with a larger sample size and involving a diverse participant cohort may enhance the strength of the evidence.
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Efficacy of probiotic co-supplementation with omega-3 PUFAs on pancreatic beta-cell function in type 2 diabetes
The current understanding of the beneficial effects of probiotics in type 2 diabetes (T2D) relies on both animal and clinical data, which focus mainly on their impact on insulin resistance. The use of high-dose omega-3 polyunsaturated fatty acid (PUFA) therapy has been well tolerated in pilot trials and could have a positive effect on the…
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In vivo analysis of conservation of tooth structure using conventional method, loupes, and dental operating microscope — A randomized clinical trial
CONCLUSION: Magnification-assisted endodontics significantly improves the precision of access cavity preparation. While the DOM offers optimal dentin conservation and enhanced canal orifice detection, surgical loupes strike a balance between improved visualization and procedural efficiency. The integration of magnification tools in pediatric endodontics will surely enhance clinical outcomes, although practical considerations such as cost, training, and…
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Good Outcome Following Attempted Resuscitation Score and Clinical Frailty Scale for Estimating Long-Term Mortality: An Ancillary Study of the CLEAR Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this ancillary study of the CLEAR trial, the GO-FAR score and CFS effectively estimated long-term all-cause mortality, particularly when combined with the CCI. These tools may help clinical decision-making, resource allocation, and advanced care planning in aging, multimorbid patient populations.
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Health Care Professional Willingness to Treat Opioid Use Disorder vs Type 2 Diabetes in Primary Care
CONCLUSIONS AND RELEVANCE: These findings suggest that PCPs have positive attitudes toward treating OUD yet more willingness to treat type 2 diabetes in primary care. Future implementation studies are needed to support MOUD prescribing in primary care.
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Colorectal Cancer and Advanced Adenoma after Single CT Colonography or Biennial FIT Screening in the SAVE Randomized Controlled Trial
Background A 5-year screening interval for CT colonography (CTC) and a 2-year screening interval for fecal immunochemical tests (FITs) have been recommended on the basis of the natural history of colorectal cancer (CRC). Purpose To assess whether the recommended 5-year interval for screening CTC is appropriate and whether CTC is associated with earlier diagnosis relative…
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Brain Frailty and Functional Outcomes After Thrombolysis for Acute Ischemic Stroke
CONCLUSIONS AND RELEVANCE: In this cohort study of patients with AIS treated with intravenous thrombolysis, brain frailty markers-particularly white matter changes, cortical atrophy, and total brain frailty-were associated with worse outcomes. Consideration of these neuroimaging markers may better inform clinicians and patients about treatment expectations from thrombolytic therapy.
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Comparison of cheese with and without Propionibacterium freudenreichii subsp. shermanii LMGT 2951 on off-season muscle strength and VO(2) max development in Nordic skiers: a randomized clinical trial
CONCLUSION: Both Jarlsberg cheese, characterized by its unique Propionibacterium freudenreichii content, and Norvegia cheese, when combined with off-season training, led to increases in LBM, VO₂ max, and MS, with no significant differences observed between groups. However, there was a trend toward greater improvements in MS in the Jarlsberg group. Overall, increases in LBM through structured…
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Prevalence and predictors of nonceliac wheat sensitivity in refractory irritable bowel syndrome and functional dyspepsia: results from a randomized double-blind placebo-controlled study
CONCLUSION: Approximately one-fifth of the patients with refractory IBS/FD fulfill the NCWS criteria. Therefore, screening for NCWS in patients with refractory IBS or FD is extremely important to limit unnecessary pharmacotherapy and enhance patient outcomes.
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Neoadjuvant therapy with eribulin, doxorubicin and cyclophosphamide for patients with HER2-negative inflammatory breast cancer: a phase II study
CONCLUSIONS: Despite the low pCR rate, all patients were able to undergo curative surgery, and long-term outcomes were encouraging with 5-year EFS 85.6%. Decreases in tumor vascularization with treatment were detected by DCE-MRI parameters irrespective of initial chemotherapy received. Adipogenesis/fatty acid metabolism and cells associated with immunosuppression are potential mechanisms of resistance and targets for…