Clinical Trials
Category Added in a WPeMatico Campaign
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Deucravacitinib With Add-On Calcipotriene/Betamethasone Dipropionate for Treating Moderate to Severe Plaque Psoriasis
BACKGROUND: To assess the effectiveness, safety, and quality of life in patients who received topical calcipotriene/betamethasone dipropionate (C/BD) foam added to oral deucravacitinib for treating moderate to severe, chronic plaque psoriasis.
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Designing and evaluation of the effect of community-based intervention on breast self-examination among reproductive-aged women in Ethiopia: A Cluster Randomized Controlled Trial
CONCLUSIONS: The study found that there is a strong interplay between the likelihood of performing breast self-examination and perceived susceptibility, perceived severity, knowledge, and health motivations. Field specialists should figure out the problem related to perception and awareness through intensive health promotion interventions.
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Multicenter Prospective Randomized, Double-Blind, Placebo-Controlled Pharmacodynamic Study of The Additional Antihypertensive Effect of the Drug in Patients With Uncontrolled Arterial Hypertension Against the Background of Taking Renin-Angiotensin-Aldosterone System Blockers
Aim To evaluate the efficacy and safety of a single sublingual dose of captopril in patients with poor control of arterial hypertension (AH) despite continuous use of long-acting angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs). The safety of a single additional dose of a short-acting ACE inhibitor to relieve elevations of blood…
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Carfilzomib-lenalidomide-dexamethasone versus lenalidomide-dexamethasone in patients with newly diagnosed myeloma ineligible for autologous stem-cell transplantation (EMN20): a randomised, open-label, multicentre, phase 3 trial
BACKGROUND: Before the introduction of daratumumab-lenalidomide-dexamethasone as a first-line treatment for patients with newly diagnosed transplant-ineligible multiple myeloma, lenalidomide-dexamethasone was a standard of care. We aimed to explore whether addition of the second-generation proteasome inhibitor carfilzomib to lenalidomide-dexamethasone improved the rates of measurable residual disease (MRD) negativity and progression-free survival.
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A multicenter phase 2 trial in children and young adults with newly diagnosed T-ALL: ALL-T11/ T-ALL-211-U from the Japan Children’s Cancer Group and the Japan Adult Leukemia Study Group
T-cell acute lymphoblastic leukemia (T-ALL) accounts for approximately 10-15% of childhood ALL, with its incidence increasing during the adolescent and young adult (AYA) period. The Japan Children’s Cancer Group (JCCG) and the Japan Adult Leukemia Study Group (JALSG) conducted the ALL-T11/T-ALL-211-U clinical trial in newly diagnosed T-ALL patients under 25 years of age. The treatment…
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Induction therapy with bortezomib, melphalan, and prednisone followed by lenalidomide and dexamethasone versus carfilzomib, lenalidomide, and dexamethasone with or without daratumumab in older, fit patients with newly diagnosed multiple myeloma (GEM-2017FIT): a phase 3, open-label, multicentre, randomised clinical trial
BACKGROUND: Triplet and quadruplet regimens based on bortezomib, melphalan and prednisone (VMP) and lenalidomide and dexamethasone (Rd) with anti-CD38 antibodies are potential treatments for transplant-ineligible patients with newly diagnosed multiple myeloma. However, the high risk of toxic effects in this population requires frailty-based therapy adaptation. We aimed to compare the response of carfilzomib-based triplet and…
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Blending electronic techniques with traditional teaching methods to enhance chest X-ray interpretation in medical students
CONCLUSION: Both traditional and blended E-learning improved students’ chest x-ray interpretation skills. However, the study found that the group receiving electronic training showed more noticeable positive changes, significantly increasing students’ self-confidence. A combination of E-learning and traditional methods significantly improves chest radiograph interpretation among young students. Early integration of E-learning for CXR interpretation in the…
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Addiction Consult Services, Mortality, and Acute Care Utilization in Inpatients With Opioid Use Disorder: A Secondary Analysis of a Cluster Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this prespecified secondary analysis of a cluster randomized clinical trial, postdischarge ED visits decreased with the CATCH program, highlighting the potential of hospital-based addiction consult services to address needs of patients with opioid use. Nonetheless, high rates of acute care utilization and mortality persisted, underscoring the need for comprehensive care strategies…
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Early Change in Depressive Symptom Severity With Naltrexone-Bupropion Combination and Its Association With Reduction in Methamphetamine Use in ADAPT-2 Trial
Objective: This study evaluated whether depressive symptom severity improved early with extended-release naltrexone and bupropion combination (naltrexone bupropion) compared to a placebo in individuals with moderate/severe methamphetamine use disorder and predicted subsequent use of methamphetamine.
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Efficiency of remote monitoring and guidance in blood pressure management: a randomized controlled trial : The role of remote monitoring in improving hypertension management
CONCLUSIONS: Remote monitoring and guidance enhanced the efficiency of BP management, whereas self-monitoring alone proved to be ineffective.