Clinical Trials
Category Added in a WPeMatico Campaign
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Improving physiotherapists’ ability to recognise the presence of a serious pathology with a digital educational training: a mixed methods feasibility study
CONCLUSIONS: Our findings suggest that a digital educational training aimed at improving physiotherapists’ ability to detect serious pathologies is feasible. Participants emphasized the importance of adaptable platforms and a variation in digital materials to enhance the training. Limitations included the need for additional complex vignettes and limited participation in face-to-face discussions. Future research should explore…
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The effect of a Web-Based BF education program for adolescent pregnant women in the third trimester on BF practices
CONCLUSIONS: It was concluded that the web-based breastfeeding education program effectively improved breastfeeding self-efficacy, breastfeeding success, exclusive breastfeeding rates, and intentions to breastfeed for up to two years.
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Impact of liberal versus restrictive fluid management on acute kidney injury after nephrectomy: a randomised controlled trial with cystatin C evaluation
CONCLUSIONS: A liberal intraoperative fluid strategy significantly reduced the incidence of AKI following nephrectomy. Serum cystatin C outperformed creatinine in the early detection of AKI, suggesting a liberal fluid strategy may be preferable to reduce AKI risk, and cystatin C may serve as a useful early AKI biomarker.
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Smaller infarct size with ticagrelor vs. clopidogrel in STEMI patients: Insights from cardiac magnetic resonance
CONCLUSION: In patients with STEMI under a pharmaco-invasive strategy, therapy with ticagrelor was associated with a smaller infarct size than clopidogrel.
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A Culturally and Linguistically Tailored Intervention to Improve Diabetes-Related Outcomes in Chinese Americans With Type 2 Diabetes: Pilot Randomized Controlled Trial
CONCLUSIONS: The culturally and linguistically tailored intervention showed promise in improving self-efficacy and diabetes self-care activities among Chinese Americans with T2D, warranting validation through a large-scale randomized controlled trial.
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A Randomized Controlled Trial of Stereotactic Body Radiation Therapy Versus Chemoradiation Following Induction Chemotherapy in Borderline Resectable and Locally Advanced Pancreatic Cancer
CONCLUSION: SBRT showed superior resectability, survival outcomes, and QoL compared to CRT in patients with BRPC and LAPC. However, due to the study’s small sample size and single-centre design, these findings are hypothesis-generating and warrant validation in larger multicentre trials.
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Long-term efficacy of three treatments for severe MGD: a comparative study in Chinese patients
CONCLUSION: MGX, IPL+MGX, and LipiFlow were all effective in improving signs and symptoms in severe MGD. IPL+MGX provide the most consistent long-term benefits in stabilizing tear film and alleviating symptoms.. These findings highlight the importance of individualized treatment strategies based on MGD severity and patient factors.
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On-treatment modified Glasgow Prognostic Score (mGPS) in hepatocellular carcinoma treated with atezolizumab and bevacizumab provides prognostic information
CONCLUSIONS: The on-treatment mGPS, as well as ACR and AIR, predicted outcomes in patients with HCC independent of and more accurately than radiological staging. Since, the mGPS is the most cost effective and widely validated score, we consider it best suited for clinical use. Prospective validation is needed to confirm these findings.
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Problem-solving training to improve caregiver burden and depressive symptoms among dementia caregivers: personal and clinical factors of responders vs. non-responders
CONCLUSION: Most caregivers demonstrated a clinically meaningful improvement in caregiver burden and/or depressive symptoms after receiving PST/DSJ. Notably, those who responded had higher symptoms of distress, including caregiver burden and overload and depressive symptoms and lower life satisfaction, and had care recipients with more severe dementia, indicating that those benefiting from the intervention were those…
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Traditional Chinese Medicine Combined Group Psychotherapy Experiences Among Colorectal Cancer Survivors: A Secondary Qualitative Analysis
CONCLUSION: During TCM combined online group psychotherapy interventions-including education, skill-building, TCM lifestyle coaching, and peer-exchange platforms-patients developed sustained self-health management practices, improving psychological resilience and physical symptoms. This holistic, tailored and culturally sensitive approach fostered long-term recovery and independence of CRC survivors.