Clinical Trials
Category Added in a WPeMatico Campaign
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Christmas article: Alcohol induced rhinitis
CONCLUSION: Beer may provoke transient nasal congestion more than wine, although the difference was not statistically significant. Findings support the hypothesis that some Christmas »sniffles« may be alcohol-related rather than viral.
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Preventive Effect of Shenfu Injection on Arrhythmia After Percutaneous Coronary Intervention in Patients With ST-Segment Elevation Myocardial Infarction: A Prospective Randomized Controlled Trial
CONCLUSIONS: Treatment with Shenfu injection as an adjunctive therapy to standard treatment in patients with STEMI undergoing PCI significantly reduced in-hospital arrhythmias, infarct size, microvascular obstruction, and major adverse cardiac events during a 12-month follow-up period. The independent effect on arrhythmias after comprehensive statistical adjustment and the demonstrated correlation between reduced myocardial damage and arrhythmia…
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Nudging Emergency Department Clinicians to Reduce Unnecessary Diagnostic Test Ordering: A Multi-Arm Vignette-Based Experiment
CONCLUSION: While potentially of limited value for reducing the total number of tests ordered, nudge-based clinical decision support interventions that manipulate decision structure and employ decision assistance may reduce tests other than FBE and U&E in emergency departments, especially among less experienced clinicians.
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Enhanced Eustachian Tube Function and Hearing Recovery with Combined Balloon Dilatation and Tympanic Membrane Catheterization in Secretory Otitis Media
BACKGROUND Secretory otitis media (SOM), a common otorhinolaryngological disorder, impairs hearing and quality of life. Eustachian tube balloon dilatation (ETBD) is increasingly used, and its combination with tympanic membrane catheterization (TMC) may enhance outcomes. This study compared ETBD alone with ETBD combined with TMC in adult SOM. MATERIAL AND METHODS Ninety patients (110 ears) with…
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A Phase II Pilot Study of Anti-PD-L1, Durvalumab, and a PARP Inhibitor, Olaparib in Patients With Metastatic Triple-Negative Breast Cancer With or Without Germline BRCA Mutation
CONCLUSION: Our study demonstrated modest clinical benefits of D + O with ORR of 28.6% in subsets of heavily pretreated TNBC. Further detailed classification of DCs to understand the predictive role of DCs and prospective validation in a large cohort is required.
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Virtual Standardized Patients for Improving Clinical Thinking Ability Training in Residents: Randomized Controlled Trial
CONCLUSIONS: VSPs reinforce the foundational knowledge of internal medicine among medical students and enhance their clinical thinking abilities, as well as improve their capacity for independent work. The VSP system is feasible, practical, and cost-effective, making it worthy of further promotion in clinical education.
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Compression Hosiery to Avoid the Post-Thrombotic Syndrome: a synopsis of the CHAPS RCT
CONCLUSIONS: The sample size was not reached, which precluded any formal statistical analysis. Although a difference in the incidence of post-thrombotic syndrome was demonstrated, the effect size could not be determined. There is interest in understanding optimal strategies for the prevention of post-thrombotic syndrome in these patients and a re-run of this trial should occur.
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Home-Based Gamma Transcranial Alternating Current Stimulation in Patients With Alzheimer Disease: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, home-based gamma tACS was feasible and improved clinical outcomes in AD, with neurophysiological evidence of brain engagement. These findings support further investigation of gamma tACS as a potential therapeutic intervention for AD.
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Influence of an internet-based proactive follow-up management model on the prognosis of nonalcoholic fatty liver disease
CONCLUSION: The internet-based proactive follow-up management model can provide personalized health management plans and reduce the risk of disease deterioration, making it worthy of promotion in a broader healthcare context.
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Roasting oat-based paste modulates postprandial glucose and insulin sensitivity: Roles of acrylamide, texture, and starch fractions
Oat-based foods are widely recommended for dysphagia management and glycemic control, yet the impact of roasting conditions on their health benefits remains unclear. This study compared the postprandial glycemic and insulinemic responses to oat pastes prepared from low-temperature (90-110 °C) and conventional high-temperature (160 °C) roasted oat flours, using refined rice (R) as a reference,…