Clinical Trials
Category Added in a WPeMatico Campaign
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Comparison of 3 different flow rates of high-flow nasal cannula (1 L/kg/min versus 2 L/kg/min versus 3 L/kg/min) in management of children admitted with bronchiolitis: a randomized controlled trial
CONCLUSION: HHFNC at 1 L/kg/min showed good clinical with fewer improvement adverse events, while 2 L/kg/min had the lowest PICU admissions and ventilation needs. In contrast, 3 L/kg/min was linked to higher complications and longer hospital stay.
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Optimizing lenalidomide therapy in renal impairment: analysis of renal response in the prospective REMNANT study in transplant-eligible newly diagnosed multiple myeloma
Renal impairment (RI) is a serious complication in multiple myeloma (MM), linked to poor survival and early mortality. Rapid renal recovery improves outcomes, yet patients with RI have been excluded from most key trials in transplant-eligible newly diagnosed (TE-ND) MM. REMNANT is an ongoing, academic, multicenter phase 2/3 study in TE-NDMM patients aged 18-75, regardless…
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Concentrated ERP for Patients With Difficult-to-Treat OCD: Insight as a Predictor of Acute and Long-Term Outcomes
CONCLUSIONS: Baseline insight was not a strong predictor of short-term treatment outcomes following cET but was related to long-term OCD severity. Improvements in insight during cET were associated with achieving and maintaining reduced symptoms over time. These results suggest that improvements in OCD and enhanced insight are associated. Trial Registration: ClinicalTrials.gov identifier: NCT02656342.
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Multiparameter MRI assessment of metformin and exercise effects on skeletal muscle in prediabetes: a randomized controlled trial
CONCLUSION: Aerobic exercise favorably altered skeletal muscle tissue characteristics and metabolic markers in prediabetes. Metformin did not attenuate these effects and may enhance IMAT reduction in subjects with high baseline IMAT.
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Efficacy and safety of tranilast combined with minocycline in the treatment of moderate-to-severe rosacea: a prospective, randomized controlled study
CONCLUSION: In our study, patients with moderate to severe rosacea treated with tranilast showed a favorable clinical response and experienced no serious adverse events. The combination therapy yielded better outcomes than minocycline monotherapy, especially in improving facial erythema.
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Tele-ophthalmology-enabled and artificial intelligence-ready referral pathway for community optometry referrals of retinal disease: HERMES cluster randomised trial with a diagnostic accuracy study
CONCLUSIONS: Asynchronous teleophthalmology reduces the number of unnecessary urgent referrals, the main drivers of increasing hospital capacity pressures, provides more appropriate referral-to-treatment times and is more cost-effective compared to standard care. The Octane artificial intelligence model could not process images from 48.5% of study participants. Compared to hospital-based experts for referral decisions, Octane was less…
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Efficacy and safety of iguratimod in patients with primary Sjogren’s syndrome: a multicentre randomised controlled trial
CONCLUSION: IGU monotherapy demonstrated significant improvements in composite, systemic and serologic outcomes compared with HCQ in active pSS and was well-tolerated. These findings establish IGU as a promising therapeutic option for pSS, particularly in the subset of patients with hyperglobulinaemia.
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Association of race and survival in patients treated with apalutamide: Pooled analysis of two phase 3 trials
CONCLUSIONS: In this study, the authors did not find any evidence of difference in the treatment effect of apalutamide on OS across patients of different races, although interpretation remains limited by poor representation of racial minorities. Among apalutamide-treated patients, there was no association of race with OS.
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Remote ischemic conditioning in necrotizing enterocolitis: an extended phase I safety study
CONCLUSIONS: RIC intervention with 5-min ischemia-reperfusion cycles is safe. RIC is also safe when extended to extremely preterm neonates with confirmed medical or surgical NEC.
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Pooled randomised QUARTET trials assessing effectiveness of a single pill for hypertension
CONCLUSION: This prospective individual participant data pooled analysis provides further evidence that the quadpill strategy is superior to initial monotherapy by virtue of improved BP-lowering, less need for uptitration and being associated with less treatment inertia.