Clinical Trials
Category Added in a WPeMatico Campaign
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Application and Efficacy Evaluation of a Modified Ostomy Appliance in Managing Peristomal Irritant Contact Dermatitis: A Randomised Controlled Trial
Irritant contact dermatitis is a common peristomal skin complication. Due to the continuous irritation from intestinal fluids and faeces, the healing of this dermatitis is slow and the condition severely impairs patients’ quality of life. The study aimed to evaluate the efficacy of a modified insertable ostomy appliance in promoting healing and improving patient outcomes.…
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Perceived health, musculoskeletal disorders, work conditions and safety climate in relation to patient handling and movement - a multicentre cross-sectional study at healthcare workplaces
CONCLUSIONS: Substantial physical and organizational challenges related to PHM were reported by HCWs across both care contexts. The findings suggest that interventions emphasizing leadership engagement, a systematic approach to training, and tailored solutions are essential to strengthen the safety climate and reduce HCWs’ health risks.
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Group-Based Relational Savoring Intervention in Mothers of Young Children in Iran: Testing Impacts of Memory Type
Relational savoring, a prevention/intervention approach that involves reflecting on positive moments of connection with another person, promotes wellbeing in the parenting relationship. In this program, parents savor memories with strong attachment content (including Secure Base or Safe Haven memories), but it is currently unknown whether the benefits of relational savoring differ as a function of…
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Ten-year target lesion failure in patients treated with primary PCI: results from DANAMI-3
CONCLUSIONS: One in five STEMI patients treated with primary PCI experiences TLF within 10 years, accounting for a significant proportion of any mortality, any MI or any revascularisation, with sustained occurrence rates beyond the first year.
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Cost-effectiveness of a technology-assisted peer-delivered perinatal mental health intervention in Pakistan: an economic evaluation using trial evidence
CONCLUSIONS: Our analysis suggests that THP-TAP could represent a scalable, health-improving and cost-saving intervention to support those with perinatal depression, when compared with WHO-THP.
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Perceived effectiveness of messages to address cervical cancer screening barriers: An online experiment
CONCLUSIONS: Messages targeting known barriers to cervical cancer screening were perceived as more effective than a control message. These messages could increase cervical cancer screening rates if used in interventions at scale.
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Quality Improvement Intervention to Increase Sleep Apnea Diagnostic Testing After Stroke and Transient Ischemic Attack: A Cluster Randomized Trial
CONCLUSIONS AND RELEVANCE: In this cluster randomized trial of patients with acute cerebrovascular events, quality improvement approaches increased OSA testing. These results suggest that health care systems can improve the delivery of guideline-concordant care for patients with acute ischemic stroke and TIA by delivering inpatient sleep medicine services.
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Transepidermal Water Loss in Oral Food Challenges in Children With Peanut Allergy: A Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this randomized clinical trial, prospective use of TEWL as a stopping criterion reduced anaphylaxis rates during OFC in children with peanut allergy, suggesting use of TEWL could make OFC safer and more accessible. Replicating this study in a larger, multicenter population is a reasonable next step.
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Ablative Preoperative Single-Fraction Radiation Dose Escalation Among Patients With Breast Cancer: A Phase 1 Nonrandomized Clinical Trial
CONCLUSIONS AND RELEVANCE: In this nonrandomized clinical trial, the rate of toxic effects was low, and treatments were tolerable up to 38 Gy. Delaying surgery more than 9 months after sPBI with endocrine therapy was associated with increased pCR and npCR (>90%), while higher doses were not. These findings support further investigation of sPBI as…
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Integration of a WASH Component in the Standard National Protocol for Treatment of Severe Acute Malnutrition in Children Aged 6-59 Months in Northern Senegal-A Costing Study
Severe acute malnutrition (SAM) affects 12.2 million children globally. Integrating a water, sanitation and hygiene (WASH) kit in outpatient SAM treatment can improve recovery rates by preventing WASH-related diseases and complications, but its cost at scale remains unknown. This study estimates the cost of integrating a WASH kit, composed of chlorine-based water treatment, safe water…