Clinical Trials
Category Added in a WPeMatico Campaign
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Effects of dry needling and kinesio taping in temporomandibular dysfunction: a randomized trial
CONCLUSION: Dry needling and kinesio taping are effective, safe, and clinically feasible interventions for the management of TMD. Dry needling, in particular, appears more effective in reducing pain and improving function. These findings highlight the importance of incorporating conservative physical therapy approaches within multidisciplinary TMD treatment protocols.
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Neoadjuvant Immunotherapy With Prolgolimab in Patients With Locally Advanced Microsatellite Instability/Defective Mismatch Repair Colorectal Cancer
CONCLUSION: The use of prolgolimab in locally advanced dMMR/MSI CRC is associated with high rates of pCR and cCR, allowing for further exploration of organ-sparing approaches in these patients.
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Effect of core stabilization exercises on antioxidant/oxidant levels in hypertensives
CONCLUSION: Core stabilization exercises may improve oxidative balance and endothelial function in patients with hypertension.
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Cognitive function during endocrine treatment with or without cyclin-dependent kinase 4/6 inhibitors for advanced breast cancer
CONCLUSIONS: Patients with HR^(+)HER2^(-) ABC showed impaired cognitive function at initial diagnosis compared to cancer-free controls. During first-line endocrine treatment with aromatase inhibitors, cognitive function declined in a small group of patients, regardless of the addition of CDK4/6i.
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Oral Lacticaseibacillus rhamnosus GG Exposure During Pregnancy and Effects on Maternal Inflammatory Response-A Blinded, Pilot Randomized, Placebo-Controlled Study
CONCLUSIONS: Although L. rhamnosus GG did not significantly affect TNF-α levels, its influence on lymphocyte and cytokine levels warrants further investigation through larger trials.
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Comparison of the efficacy of intense pulsed light, 0.05% cyclosporine A eye drops, and 3% diquafosol sodium eye drops in the treatment of moderate to severe dry eye: A prospective cohort study
The study aimed to compare the efficacy of intense pulsed light (IPL), 0.05% cyclosporine A (CsA) eye drops, and 3% diquafosol sodium (DQS) eye drops in treating moderate to severe dry eye. A cohort of 180 patients diagnosed with moderate to severe dry eye was enrolled in the Department of Ophthalmology at Quzhou People’s Hospital…
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Impact of vaginal microbiota on the clinical efficacy and long-term recurrence of ketoconazole suppositories in treating severe vulvovaginal candidiasis: a secondary analysis of a multicentre randomised trial
CONCLUSION: The vaginal microbiota, particularly the dominant bacteria, may influence treatment efficacy and recurrence rates. In the treatment of severe vulvovaginal candidiasis, ketoconazole suppositories are not inferior to miconazole nitrate vaginal capsules in clinical efficacy and have a lower long-term recurrence rate.
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Impact of desflurane versus isoflurane on early cognitive function of the elderly undergoing lumbar surgery: a randomized clinical trial
CONCLUSION: Desflurane had less impact on postoperative cognitive function of the elderly patients and had less interference with expression of LINC01844. The relative level of LINC01844 in peripheral blood may be a potential biomarker for POCD.
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Association of blood pressure control with atrial and ventricular ectopy in SPRINT
CONCLUSION: Intensive BP control did not reduce the incidence of cardiac ectopy in patients with hypertension. Given the variable nature of PAC and PVC burden, further studies with continuous monitoring or more frequent sampling in larger populations are warranted.
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(61)Cu-NODAGA Prostate-specific Membrane Antigen Imaging and Therapy for Prostate Cancer: Phase 1 Trial of a New Class of (61)Cu-labeled PET Radiotracers
Background Prostate-specific membrane antigen (PSMA)-targeted PET has revolutionized prostate cancer imaging, but the sensitivity at low prostate-specific antigen levels is lacking. Copper 61 (^(61)Cu) is a positron emitter with favorable physical characteristics that allow for delayed imaging, which may result in improved sensitivity. Purpose To evaluate the safety, dosimetry, optimal imaging parameters, and initial efficacy…