Clinical Trials
Category Added in a WPeMatico Campaign
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Effects of a Multi-Component Nutraceutical (NUT2) on the Lipid Profile in Adults with Low-to-Moderate Cardiovascular Risk: A Randomized Placebo-Controlled Trial
Background: Lifestyle intervention is recommended as first-line management for individuals with low-to-moderate cardiovascular (CV) risk and elevated low-density lipoprotein cholesterol (LDL-C), although dietary intervention alone often produces only modest lipid reductions. NUT2 is a proprietary multi-component nutraceutical formulated to target complementary pathways involved in lipid metabolism, oxidative stress and cardiometabolic risk. This study evaluated its…
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Pre-existing systemic immune state and dynamic myeloid remodeling shape response to neoadjuvant PD-L1 blockade
CONCLUSIONS: A single neoadjuvant dose of atezolizumab was feasible, safe, and elicited measurable systemic immune activation in patients with resectable head and neck squamous cell carcinoma. Direct analysis of fresh blood uncovered dynamic PMN-MDSC changes as a potential novel pharmacodynamic biomarker of treatment response, emphasizing the advantages of real-time, non-frozen immune cell profiling for complete…
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Efficacy and safety of rib-guided percutaneous thoracic sympathetic radiofrequency thermocoagulation at two different targets for primary palmar hyperhidrosis: a randomized controlled trial
CONCLUSIONS: Targeting the lateral margin of the fourth rib head for RFT achieved greater efficacy, better quality of life and higher patient satisfaction compared to the upper margin target.
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Recruitment Source and Participant Retention in a Digital HIV Prevention Intervention for Young Black and Latino Men and Transgender Women: Secondary Analysis of the HealthMpowerment 2.0 Randomized Controlled Trial
CONCLUSIONS: Recruitment source was associated with both participant characteristics and long-term retention in this digital HIV prevention intervention. Social media and prior research networks yielded higher retention, whereas partner-seeking apps reached populations at higher HIV risk but were associated with lower retention. Targeted retention strategies that account for both recruitment platform and participant characteristics (including…
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Effects of the LEARNS model-based self-management education on short-term treatment outcomes among newly diagnosed tuberculosis patients: a randomized controlled trial
CONCLUSIONS: The LEARNS model-based self-management program benefits inpatients with newly diagnosed pulmonary tuberculosis. It effectively improves patients’ self-management and tuberculosis prevention and control knowledge, and improves chest radiographic findings. However, this intervention yields no significant effects on anxiety, depression, social support, and sputum bacteriological conversion.
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Effect of Sour Taste on Swallowing Function of Patients With Dysphagia After Acute Ischemic Stroke: A Randomized Controlled Trial
CONCLUSIONS: Administration of a sour taste during the early period of acute ischemic stroke had a beneficial effect on swallowing function in patients with dysphagia. Sour taste stimulation may be considered a practical, feasible, and complementary sensory intervention in post-stroke dysphagia management.
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In vivo assessment of the Optipen optical reflectometer for detecting enamel surface changes following an erosive challenge
CONCLUSIONS: The Optipen optical reflectometer detected immediate changes in enamel surface reflectance in vivo following a single erosive challenge.
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Facilitated Transitions to Postpartum Primary Care and Mental Health Care Services: Secondary Analysis of a Randomized Clinical Trial
CONCLUSIONS AND RELEVANCE: This study found that supported transitions to postpartum primary care may improve receipt of primary care-provided mental health care services. This relatively low-cost intervention may be one strategy to facilitate ongoing access to mental health care supports and treatments beyond the immediate postpartum period.
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Effect of Sexocorporel-based sexual counseling on sexual health literacy and sexual quality of life among married deaf women of reproductive age: a randomized controlled trial
CONCLUSION: Sexocorporel-based sexual counseling may represent an effective and communication-sensitive approach for improving sexual health literacy and sexual quality of life among married deaf women. Integrating disability-inclusive and visually accessible counseling approaches into sexual healthcare programs may contribute to more equitable sexual healthcare services for women with hearing disabilities.
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Manual, digital, and AI tumour-infiltrating lymphocyte scoring: a secondary analysis of the APHINITY randomised trial
BACKGROUND: Stromal tumour-infiltrating lymphocytes (sTILs) are prognostic in early-stage HER2-positive breast cancer, but their role in the context of dual HER2 blockade remains undefined. We evaluated manual, digital, and artificial intelligence (AI)-based sTIL quantification, together with AI-derived spatial metrics, for prognostic and treatment-benefit stratification using tumour samples from the phase 3 APHINITY trial.