Clinical Trials
Category Added in a WPeMatico Campaign
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Evaluation of the clinical efficacy of accelerated photoactivated chromophore for keratitis-CXL for early to mid-stage fungal keratitis: a prospective, multicenter randomized controlled trial
CONCLUSIONS: This first RCT demonstrates that adjuvant accelerated PACK‑CXL significantly hastens clinical recovery, reduces disease burden and corneal transplantation rate, and shortens healing time in mild-to-moderate fungal keratitis, with a favorable safety profile.
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A clinical study on fall risk assessment and preventive nursing in older adults with non-Hodgkin’s lymphoma undergoing chemotherapy-a randomized controlled trial
CONCLUSION: A targeted, multifactorial nursing intervention substantially reduced falls and fall-related complications among older adults with NHL receiving chemotherapy. Integration of fall prevention measures into routine oncologic care is strongly recommended to safeguard treatment continuity and patient well-being. Further multicenter and long-term studies are warranted to validate these findings and refine comprehensive fall prevention strategies.
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Does Cognitive Bias Modification for Appraisals Change Symptom-Cognition Relations in PTSD? Preliminary Evidence from Network Analysis in a Randomized Controlled Trial
CONCLUSION: Given the small sample and moderate network stability, findings are preliminary but suggest that CBM-APP may influence the relational structure of PTSD symptoms and cognitions.
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A phase III double-blind, placebo-controlled, randomized withdrawal trial of 5-aminolevulinic acid hydrochloride with sodium ferrous citrate for efficacy and safety in patients diagnosed as Leigh syndrome
CONCLUSION: These findings suggest that SPP-004 is safe and may provide therapeutic effect for LS patients who achieved an initial clinical response.
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Accuracy and safety of C-TST for tuberculosis infection: A clinical trial in Brazil
CONCLUSION: In BCG‑vaccinated adults, C-TST showed a trade-off of higher specificity and lower sensitivity than PPD RT-23 at the 5-mm cut-off; and a favourable safety profile. Adding erythema to readings did not improve accuracy, suggesting that C-TST may be a useful alternative for programmatic TBI screening in high-burden settings.
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Comparison of Early Bracing Versus Splinting for the Initial Treatment of Acute Humeral Shaft Fractures (The COBRAS Trial)
CONCLUSIONS: Immediate Sarmiento bracing was associated with increased patient-reported pain (roughly 1 point on the 0-10 numeric rating scale) and higher skin complication rates during the initial 10-day period after injury compared with initial coaptation splinting for acute humeral shaft fractures, without demonstrable benefits in function, analgesic requirements, or patient satisfaction. These findings support the…
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Effectiveness and acceptability of biometrics to evaluate intervention coverage and contamination in a cluster randomised trial of community-based sexual and reproductive health services for youth in Zimbabwe
CONCLUSION: Biometric identification is useful for assessment of CRT coverage and contamination.
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Intranasal Oxytocin for Alcohol Use Disorder: A Randomized, Double-Blind, Placebo-Controlled Multisite Trial Assessing Efficacy and Safety
CONCLUSION: Intranasal oxytocin was well tolerated but did not significantly reduce drinking or AUD-related outcomes. Higher doses, longer treatment duration, or larger trials may be required to identify responsive subgroups and determine oxytocin’s efficacy in AUD.
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Effects and User-Reported Experiences of a Self-Management Mobile Health App for Grieving Adolescents: Randomized Controlled Trial
CONCLUSIONS: Overall, the findings indicate that Alba may be beneficial in reducing mental health symptoms among bereaved adolescents and highlight its potential as a safe, acceptable, and scalable mHealth intervention.
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Expectant management versus acetaminophen for early treatment of hemodynamically significant patent ductus arteriosus in very preterm infants: a randomized controlled trial
CONCLUSIONS: Early oral acetaminophen treatment in very preterm infants with hsPDA aged 4-7 days reduces the rate of persistent hsPDA at 14-17 days and demonstrates a favorable safety profile compared with expectant management, but does not affect hsPDA persistence at discharge or 36 weeks of corrected gestational age or the rate of moderate to severe…