Clinical Trials
Category Added in a WPeMatico Campaign
-
Comparative Analysis of Postoperative Recovery and Analgesia in Gynecologic Laparoscopic Surgery with Total Intravenous Anesthesia Versus Combined Intravenous Inhalational Anesthesia Both with Ultrasound Guided Transversus Abdominis Plane Block: A Randomized Controlled Trial
CONCLUSION: TIVA combined with ropivacaine TAP block accelerates early recovery, improves analgesia, attenuates surgical stress, and reduces nausea/vomiting.
-
Effects of Esketamine-Dexmedetomidine Combination on Immediate Postprocedural Oxygenation Index in Severe Pneumonia Patients Undergoing Bedside Fiberoptic Bronchoscopic Sputum Aspiration: A Prospective Randomised Controlled Trial
CONCLUSION: Compared with conventional sedation protocols, the ESK-DEX combined regimen demonstrated superior OI preservation immediately after procedure, enhanced OI within 24 hours postoperatively, improved hemodynamic stability, and enhanced safety profile in severe pneumonia patients undergoing bedside FOB-guided suction therapy. This pharmacodynamic synergy addresses critical gaps in FOB sedation-simultaneously preventing hypoxemia, maintaining respiratory drive, and minimizing…
-
Network pharmacology-based analysis of the antithrombotic clinical efficacy and antithrombotic mechanism of Huoxue Jiedu prescription in the treatment of polycythemia vera with heat toxin and blood stasis syndrome
CONCLUSION: Network pharmacology predicted the corresponding targets of traditional Chinese medicine to a certain extent. Huoxue Jiedu prescription could enhance clinical efficacy, improve hematological indicators, and reduce coagulation indicators through antithrombotic effect by inhibiting the expression of PI3K and AKT1.
-
Traditional Chinese Medicine treatment with syndrome differentiation for patients with severe community-acquired pneumonia: a multicenter, randomized, placebo-controlled trial
CONCLUSION: Among patients with severe CAP, TCM treatment with syndrome differentiation reduced treatment failure, time to clinical stability, and the 28-d mortality and the 90-d mortality among patients admitted to the ward, without an increase in complications.
-
Real-World Effects of Home-Based Transcranial Direct Current Stimulation in Depression: A Randomized Controlled Trial of 3-Week Versus 6-Week Protocols
CONCLUSIONS: Both 3-week and 6-week active tDCS protocols were associated with improvements in depressive symptoms and cognitive function over time in this naturalistic clinical context; however, as the study did not include a sham control, these changes should be interpreted as comparative rather than causal effects. The 3- and 6-week protocols demonstrated similar therapeutic outcomes,…
-
Effects of Blueberry Supplementation on Depression and Anxiety Symptoms in a Rural Louisiana Population
Background/Objectives: Blueberries are an important nutraceutical due to their excellent nutritional profile, with particularly high levels of polyphenols and anthocyanins. These compounds can improve mood, cognition, and health. As such, blueberry consumption can potentially benefit those coping with depression and anxiety. In this regard, there is an unmet need for novel, effective, and accessible treatments…
-
Marine omega-3 PUFA Supplementation Enhances FFAR4 Activation and Reduces Inflammatory Markers in PBMC of Subjects with Obesity: A Randomized Controlled Trial (EPICO)
Background: It is widely accepted that low-grade chronic inflammation in obesity worsens the metabolic state and threatens patients’ lives in a long-term manner. In fact, diet therapy is the first-line treatment in which relevant nutrients such as the omega-3 polyunsaturated fatty acids (ω-3 PUFA) must be adequately consumed to counteract the established inflammation. In particular,…
-
Efficacy of Baduanjin Exercise for Sarcopenia in Older Adults: A 24-Week Randomized Controlled Trial
CONCLUSIONS: Regular BE markedly improved muscle function and increased muscle mass in older adults with sarcopenia, indicating a safe and effective exercise for sarcopenia management. BE, which was tailored using the short physical performance battery assessment, offers a valuable approach to help prevent and treat sarcopenia in older adults. Future research should investigate the long-term…
-
Fractional Flow Reserve to Guide Revascularization in Patients With Coronary Artery Disease Undergoing TAVR
CONCLUSIONS: Conservative management of FFR ≤0.80 lesions was linked to higher cardiovascular risk compared with either PCI of FFR ≤0.80 lesions or deferral of FFR >0.80 lesions, which had similar outcomes. These findings support an FFR threshold of 0.80 to guide coronary revascularization in patients undergoing TAVR. (Revascularization in Patients Undergoing Transcatheter Aortic Valve Implantation…
-
Patient Portal Engagement in Oncology: Results From the NU IMPACT Study in a Large Health Care System
CONCLUSION: Portal use among patients with cancer varies by sociodemographic and clinical characteristics. Findings suggest a need for targeted interventions to promote equitable use among under-represented groups and promote portal-based PRO completion for patients with higher symptom burden.