Clinical Trials
Category Added in a WPeMatico Campaign
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Individually designed fall prevention strategies compared to generic strategies for mastering complex fall risk situations in people with multiple sclerosis: study protocol of a randomised controlled trial
INTRODUCTION: Of individuals with mild-to-moderate multiple sclerosis (MS), 56% report falling at least once during a 3-month period. Several fall risk factors have been identified, but the issue is complex, with interactions between triggering factors and preceding activities and events. There is a lack of studies explicitly evaluating fall prevention strategies given as counselling over…
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Continuous or Fixed-Duration Maintenance Therapy in Multiple Myeloma
CONCLUSIONS: In this phase 3 trial involving patients with standard-risk newly diagnosed multiple myeloma who were not undergoing up-front autologous stem-cell transplantation, indefinite-duration maintenance therapy after induction therapy did not result in significantly longer overall survival than fixed-duration maintenance therapy. (Funded by the National Cancer Institute of the National Institutes of Health and Amgen; ENDURANCE…
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Medication adherence in breast cancer: a comparative analysis of self-report tools and prescription refill data
CONCLUSION: Methodological variability significantly impacts reported adherence rates. While no single «gold standard» exists, integrating brief self-reported scales with objective metrics is feasible and provides a more comprehensive and clinically informative assessment of medication use. This multi-method approach is essential for identifying at-risk patients and tailoring adherence-support interventions in oncology.
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Comparative effectiveness of extracorporeal shock wave therapy and high-intensity laser therapy in trigger finger: a randomized controlled trial
Trigger finger (TF) is stenosing tenosynovitis causing pain and impaired hand function. To compare extracorporeal shock wave therapy (ESWT) and high-intensity laser therapy (HILT) as adjuncts to home exercise in TF. In this three-arm randomized controlled trial, patients were allocated to ESWT, HILT, or home exercise alone. Active modalities were applied for 3 weeks (nine…
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Selenium-Biofortified Strawberries Improve Glucose Homeostasis and Hepatic Function: A 30-Day Randomized Controlled Trial in Healthy Adults
Background: Selenium is an essential trace element for humans that plays a key role in glucose homeostasis and hepatic function. Biofortification is a sustainable agricultural technique able to increase micronutrients and reduce pesticides in crops. Purpose: The present study aimed to examine whether the consumption of strawberries biofortified with selenium in a healthy population for…
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Non-Inferiority of a Ready-to-Drink Enteral Formula on Nutritional Status in Patients with Head and Neck Cancer: A Randomized Controlled Trial
Background/Objectives: Malnutrition affects 20-71% of patients with head and neck cancer (HNC), owing to tumor location, treatment-induced toxicities, and systemic inflammation. Enteral nutrition is preferred when oral intake is inadequate, yet standard powdered formulas require labor-intensive reconstitution and carry a contamination risk. PSU Blen, a ready-to-drink chicken-protein-based polymeric formula, was developed to address these limitations.…
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Functional Soy and Lupin Protein-Based Beverages Modulate Gut Microbiome and Attenuate Metabolic Dysregulation in Adolescent Boys with Overweight and Obesity
Background/Objectives: Given the rising prevalence of overweight and obesity in pediatric populations, identifying effective nutritional interventions for metabolic management is crucial. Beyond their nutritional value, soy and lupin proteins are recognized for their bioactive properties. We formulated two protein-enriched functional beverages and evaluated their impact on the metabolic profile and gut microbiota of adolescent boys…
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EQ-5D vision bolt-on in macular degeneration: associations with visual measures and effect on utility differences and cost-effectiveness of stereotactic radiotherapy
CONCLUSIONS: Resource use data from the trial and routine follow-up could be used for future economic models. The vision bolt-on captured quality of life differences between participants but may not be sufficiently responsive to visual acuity decline in trials where only one eye is treated.
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Effectiveness of acceptance and commitment therapy on sexual function in women infected with human papillomavirus: a randomized controlled trial
CONCLUSION: Group Acceptance and Commitment Therapy effectively enhances sexual function and overall quality of life in women with HPV, suggesting its integration into supportive healthcare interventions.
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Hydrocodone vs Oxycodone and Postoperative Pain and Opioid Use in Joint Arthroplasty
CONCLUSIONS AND RELEVANCE: In this cohort study of CYP2D6 NMs undergoing joint arthroplasty, within multimodal analgesia, hydrocodone provided comparable pain control to oxycodone with significantly lower opioid exposure, supporting its use as a viable and possibly preferable analgesic option.