Clinical Trials
Category Added in a WPeMatico Campaign
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The impact of Limosilactobacillus reuteri in combination with non-surgical periodontal therapy on periodontal clinical parameters and salivary and subgingival microbiota composition in individuals with stage III-IV periodontitis: a randomized controlled trial
CONCLUSIONS: Combining L. reuteri with non-surgical periodontal therapy may not directly improve clinical indicators. The treatment showed potential benefits by changing the microbial composition of subgingival biofilm and enhancing treatment sensitivity.
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Efficacy and safety of prophylactic simultaneous intravitreal moxifloxacin injection with standard intravitreal anti-VEGF injection procedure in cases of cystoid macular edema and macular neovascularization
CONCLUSION: Simultaneous intravitreal injection of moxifloxacin during intravitreal anti-VEGF procedure is safe and effective measure to be added to the armamentarium of prophylaxis against post injection endophthalmitis.
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Patient Reactions to Artificial Intelligence-Clinician Discrepancies: Web-Based Randomized Experiment
CONCLUSIONS: Radiologists who recommend less testing than AI may face decreased patient confidence in their expertise, but they may not face this same penalty for giving more aggressive recommendations than AI. Patients’ reactions may depend in part on whether their general preferences to maximize or minimize align with the radiologists’ recommendations. Future research should test…
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Acute Glucose Tolerance in Response to Lower- and Higher-Load Resistance Exercise in Postmenopausal Women: Contribution of Aerobic Capacity and Body Composition
Paquin, J, St-Martin, P, Lord, S-E, Gendron, P, Brochu, M, and Dionne, IJ. Acute glucose tolerance in response to lower- and higher-load resistance exercise in postmenopausal women: Contribution of aerobic capacity and body composition. J Strength Cond Res 39(6): e749-e757, 2025-Glucose tolerance (GT), fat-free mass (FFM), and V̇o2peak are known to decline after menopause. Exercise…
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Comparison of Therapeutic Outcomes Between Concomitant Therapy and Tailored Therapy for Helicobacter pylori: A Multicenter, Prospective, and Randomized Study
CONCLUSION: Considering the high eradication success rate and low severity of adverse effects, tailored therapy based on DPO-PCR is preferable to concomitant therapy without resistance testing for the treatment of H. pylori infection.
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Epicardial ablation in high-risk Brugada syndrome to prevent ventricular fibrillation: results from a randomized clinical trial
CONCLUSION: Epicardial catheter ablation was associated with a reduction in VF recurrence compared with ICD therapy alone. These findings support the use of epicardial ablation in high-risk BrS patients.
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Development and validation of a nomogram to pediatric postoperative pulmonary complications following thoracic surgery
CONCLUSION: The nomogram, based on four objective and easily assessed factors, demonstrates excellent predictive performance for pediatric postoperative pulmonary complications after one-lung ventilation, enabling early risk assessment and targeted interventions to improve patient outcomes.
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Study protocol of short versus long-term levetiracetam in brain tumors (LIBRA): a phase 3 randomized controlled trial
BACKGROUND: Seizures are common in patients with brain tumors, impacting daily life and healthcare burden. In contemporary neuro-oncology practice, levetiracetam is the most commonly prescribed anti-seizure medication (ASM). Although the practice is widely variable, levetiracetam is usually used for 2-3 years following surgery to prevent further seizures. However, the incidence of seizures post antitumoral treatment…
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Computational modelling and neural correlates of reinforcement learning following three-week escitalopram: a double-blind, placebo-controlled semi-randomised study
Reinforcement learning is a fundamental aspect of adaptive behaviour, since it involves the acquisition and updating of associations between actions and their outcomes based on the rewarding or punishing consequences. Acute experimental manipulations of serotonin have provided compelling evidence for its role in reinforcement learning. However, it remains unknown how more chronic manipulation of serotonin,…
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Effect of acarbose and vildagliptin on plasma trimethylamine N-oxide levels in patients with type 2 diabetes mellitus: a 6-month, two-arm randomized controlled trial
CONCLUSIONS: Both acarbose and vildagliptin treatments significantly reduced TMAO levels in newly diagnosed T2DM patients, with a more pronounced reduction observed in the acarbose group. Furthermore, the decline in TMAO levels correlated significantly with improvements in insulin resistance parameters.