Clinical Trials
Category Added in a WPeMatico Campaign
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Combined Treatment With Cognitive Behavioral Therapy for Insomnia and Acceptance and Commitment Therapy Enhances Objective and Subjective Reports of Sleep in Patients With Advanced Cancer
CONCLUSIONS: Multi-symptom interventions may be necessary for sustained insomnia improvements for people with advanced cancer. The FOCUS intervention is one of the first to demonstrate improvements on self-reported and actigraphic measures of sleep in addition to other symptoms (i.e., worry, uncertainty, depression, fatigue interference, distress) for this population. Future effectiveness studies are warranted given results…
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Effectiveness and satisfaction of mindfulness-based cognitive therapy for children on anxiety, depression, and internet addiction in adolescents: Study protocol for a randomized control trial
Adolescents with Internet addiction (IA) frequently encounter elevated levels of anxiety and depression, which subsequently results in the perpetuation of their addiction behaviors. Mindfulness-based cognitive therapy for children (MBCT-C) is an adapted version of traditional MBCT that targets emotional problems in children. The present study aimed to provide a framework for the implementation of a…
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Within-trial cost-effectiveness of novel macrophage-regulating treatment on wound healing in patients with diabetic foot ulcers
An M1/M2 macrophage-regulating treatment, ON101 cream, has shown its superior healing efficacy for diabetic foot ulcers (DFUs) versus standard absorbent dressing, according to a phase III trial. Given its high cost, corroborating the economic value of ON101 treatment can facilitate clinical and policy decision-makings. This study sought to evaluate the cost-effectiveness of ON101 versus an…
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Efficacy and Skin Acceptability of a Cosmetic Cream for Nasolabial Dryness and Irritation
CONCLUSIONS: The results indicate that Sterimar soothing nose cream is effective in nourishing, soothing, protecting, and moisturizing the nasolabial zone, and is well tolerated.
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A Comparison of Stockholm3, Serum Biomarkers, and Risk Calculators to Predict Prostate Cancer in a Racially and Ethnically Diverse Cohort: Evaluation of the Stockholm3 Multiethnic SEPTA Trial
CONCLUSIONS: Stockholm3 outperforms other commonly used biomarkers and risk calculators for detecting GG ≥ 2 cancer in a diverse population.
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GymBuddy and Elomia, AI-integrated applications, effects on the mental health of the students with psychological disorders
CONCLUSIONS: Our findings suggest that AI-integrated interventions like GymBuddy and Elomia may serve as effective tools for reducing psychological distress in student populations. Integrating AI technology into mental health interventions offers personalized support and guidance, addressing a crucial need in student populations. Further research is warranted to explore long-term outcomes and optimize the implementation of…
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Clinical Evaluation of the Effect of Aficamten on QT/QTc Interval in Healthy Participants
Aficamten is a next-in-class, small-molecule, cardiac myosin inhibitor in development for treating hypertrophic cardiomyopathy (HCM). This 2-part study evaluated aficamten’s impact on QTc interval in healthy participants. Part A (n = 10) was an open-label study to find the appropriate dose for thorough QT (TQT) evaluation in Part B. Part B (n = 34) was…
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Short-Term Effects of Folate Supplementation in Combination With Vitamin B6 for Treating Acute Manic Episodes in Bipolar I Disorder: A Randomized Controlled Trial
CONCLUSIONS: Our findings support the short-term use of folate as a beneficial adjunct in treating acute manic episodes in bipolar I disorder. However, the addition of vitamin B6 did not yield additional advantages. These results may inform future treatment guidelines targeting acute mania in bipolar disorder, advocating for folate supplementation as a potential strategy to…
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Impact of tele-nursing on maternal self-efficacy and anxiety in post-discharge epilepsy care: an quasi-experimental study
CONCLUSION: Tele-nursing after discharge caused a significant decrease in anxiety and increased self-efficacy of mothers in taking care of their children; therefore, it is recommended to use a comprehensive program in the form of tele-nursing according to parents’ educational needs and wishes.
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Comparison of the effect of the pulsed Er: YAG laser and topical corticosteroid on erosive oral lichen planus: a randomized clinical controlled trial
The formation mechanism of OLP is very complicated, and its treatment has always been a difficult problem. This study was to explore the feasibility of pulsed Er: YAG laser in the treatment of erosive OLP by comparing its effect with that of Triamcinolone Acetonide ointment(TA) of OLP, in order to provide new ideas for the…