Clinical Trials
Category Added in a WPeMatico Campaign
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Safety and Efficacy of Platelet-Rich Plasma versus Genicular Nerve Radiofrequency Ablation in Knee Osteoarthritis: An Open-Label, Prospective, Randomized, Clinical Trial
CONCLUSION: For patients with chronic knee osteoarthritis, intraarticular platelet-rich plasma therapy may offer superior sustained pain relief and a lower disability index compared to conventional radiofrequency ablation of the genicular nerves.
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Application of Case-Based Learning Combined with PDCA in the Training of Grassroot Surgeons for the Updates in the CSCO Guidelines for the Diagnosis and Treatment of Breast (2023)
CONCLUSION: The study concludes that the integration of the PDCA cycle with CBL significantly enhances the surgeons’ acquisition and application of updated therapeutic knowledge and skills for breast cancer.
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Analytical treatment interruption among women with HIV in southern Africa who received VRC01 or placebo in the Antibody Mediated Prevention Study: ATI stakeholder engagement, implementation and early clinical data
CONCLUSIONS: In a safe, well-tolerated ATI, 18% of 11 African women exhibited post-intervention control. Design and implementation lessons inform future ATIs in Africa. Analyses of peri-acquisition and post-ATI host and viral characteristics can inform the development of interventions for HIV cure, prevention and treatment.
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Effectiveness of stationary cycling with electromyographic biofeedback on neuromuscular control and function in individuals with knee osteoarthritis: a feasibility study
CONCLUSIONS: A six-week cycling program can alleviate pain and enhance knee function. EMG biofeedback of the vastus medialis significantly changed the neuromuscular control in the rectus femoris and vastus lateralis during cycling. Therefore, this study demonstrated that stationary cycling combined with electromyographic biofeedback training can enhance neuromuscular control of the quadriceps and potentially improve functional…
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Effects of deprescribing antidepressants in nursing home residents with dementia-a cluster randomized controlled trial
CONCLUSIONS: The intervention did not significantly reduce antidepressant use among older nursing home residents with dementia. Further optimization and testing in a larger study are needed.
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The effect of therapeutic artistic activities on anxiety and psychological well-being in adolescents with type 1 diabetes: a randomized controlled study
CONCLUSION: It was concluded that therapeutic art activities were effective in reducing anxiety and improving psychological well-being in adolescents with diabetes. It is recommended that therapeutic art activities be integrated into the care programs for children with diabetes.
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Identification of distinct disease activity trajectories in patients with psoriatic arthritis receiving tofacitinib: a post hoc analysis of two phase 3 studies
CONCLUSIONS: In patients with PsA receiving tofacitinib, five distinct trajectory groups were identified with different baseline characteristics and treatment outcomes, but no clear trends in AEs. The tofacitinib 5 and 10 mg twice daily models showed comparable trajectories and baseline characteristics. In patients with HDA, enthesitis and tender joint count may impact timing and/or magnitude…
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Evaluation of self designed breast molds in enhancing doctor patient communication
To evaluate the value of self-made breast model in preoperative communication between doctors and patients with breast cancer. 200 patients with mammary tumor were randomly divided into control group and model group (100 patients in each group). The control group received traditional preoperative interpretation, and the model group used self-made breast model to assist interpretation.…
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Effectiveness of a WeChat Mini Program-Based Intervention on Promoting Multiple Health Behavior Changes Among Chinese Patients With Cardiovascular Diseases in Home-Based Rehabilitation: Randomized Controlled Trial
CONCLUSIONS: The 10-week Healthy Action Process Approach-based WeChat mini program intervention effectively improved MVPA, FVC, integrated lifestyle indicator, psychosocial resources of behavior change, and health-related outcomes among Chinese patients with CVDs. This intervention provides a valuable addition to rehabilitation strategies aimed at promoting long-term health and activity in cardiac patients following hospital discharge.
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Effects of sake lees intake on fecal uremic toxins, plasma D-alanine, constipation, and gut microbiome in healthy adults: A single-arm clinical trial
CONCLUSION: Sake lees intake may reduce fecal uremic toxins, elevate plasma D-alanine levels, alleviate constipation, and modify the gut microbiome. However, future studies are needed to confirm these effects in patients with CKD.